Changing ABRA protein peptide to fit into the HLA-DRβ1*0301 molecule renders it protection-inducing

Biochemical and Biophysical Research Communications

Volumn 322, Issue 1, 2004, Pages 119-125

  Salazar, Luz M ^a   Alba, Martha P ^a,b   Curtidor, Hernando ^a,b   Bermúdez, Adriana ^a   Luis E Vargas, ^a   Rivera, Zuly J ^a   Patarroyo, Manuel E ^a,b  

^a FUNDACIÓN INSTITUTO DE INMUNOLOGÍA DE COLOMBIA FIDIC   (Colombia)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

ABRA protein; Conformation; Malaria; NMR; Peptide analogues; Vaccine candidate

Indexed keywords

ACIDIC BASIC REPEAT ANTIGEN; ANTIMALARIAL AGENT; HLA DR BETA1 ANTIGEN; HLA DR1 ANTIGEN; LYSYLGLUTAMYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLMETHIONYLLYSYL ASPARAGINYLVALYLASPARTYLTYROSYLISOLEUCYLGLUTAMINYLLYSYLASPARAGINYLGLUTAMINYL ASPARAGINYLLEUCYLPHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLASPARAGINYLLEUCYLGLUTAMYLHISTIDYLVALYL PROLYLTRYPTOPHYLISOLEUCYLMETHIONYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLLEUCYLGLUTAMYLASPARAGINYLVALYL PROLYLTRYPTOPHYLISOLEUCYLMETHIONYLASPARAGINYLLYSYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLLEUCYLGLUTAMYLHISTIDYLVALYL PROLYLTRYPTOPHYLISOLEUCYLMETHIONYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLMETHIONYLGLUTAMYLASPARAGINYL VALYLALANYLTRYPTOPHYLISOLEUCYLMETHIONYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYL LEUCYLPHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLMETHIONYLGLUTAMYLASPARAGINYL VALYLPROLYLTRYPTOPHYLISOLEUCYLMETHIONYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYL LEUCYLPHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLMETHIONYLGLUTAMYLASPARAGINYL VALYLPROLYLTRYPTOPHYLISOLEUCYLVALYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLHISTIDYLMETHIONYLGLUTAMYLASPARAGINYL VALYLPROLYLTYROSYLISOLEUCYLMETHIONYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; LYSYLMETHIONYLASPARAGINYLMETHIONYLLEUCYLLYSYLGLUTAMYLASPARAGINYLVALYL ASPARTYLTYROSYLISOLEUCYLGLUTAMINYLLYSYLASPARAGINYLGLUTAMINYLASPARAGINYLLEUCYL PHENYLALANYLLYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PARASITE ANTIGEN; PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HLA SYSTEM; IMMUNOGENICITY; MOLECULAR DYNAMICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SPOROZOON; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, PROTOZOAN; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HAPLORHINI; HLA-DR ANTIGENS; MALARIA VACCINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 4143116695     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.07.086     Document Type: Article

References (24)

1. World Health Organization, World malaria situation in 1992, Weekly Epidemiol. Rec. 69 (1994) 309-314
2. A. Kushwaha, A. Perween, S. Mukund, S. Majumdar, D. Bhardwaj, N.R. Chowdhury, and V.S. Chauhan Amino terminus of Plasmodium falciparum acidic-basic repeat antigen interacts with the erythrocyte membrane through band 3 protein Mol. Biochem. Parasitol. 122 2002 45 54
3. M.J. Nwagwu, D. Haynes, P.A. Orlandi, and J.D. Chulay Plasmodium falciparum: chymotryptic-like proteolysis associated with a 101-kDa acidic-basic repeat antigen Exp. Parasitol. 75 1992 399 414
4. H. Curtidor, M. Urquiza, J.E. Suarez, L.E. Rodríguez, M. Ocampo, A. Puentes, J.E. Garcia, R. Vera, R. Lopez, L.E. Ramirez, M. Pinzon, and M.E. Patarroyo Plasmodium falciparum acid basic repeat Antigen (ABRA) peptides: erythrocyte binding and biological activity Vaccine 19 2001 4496 4504
5. M.F. Good, S. Kumar, and L.H. Miller The real difficulties for malaria sporozoite vaccine development: nonresponsiveness and antigenic variation Immunol. Today 9 1988 351 355
6. F. Espejo, M. Cubillos, L.M. Salazar, F. Guzman, M. Urquiza, M. Ocampo, Y. Silva, R. Rodriguez, E. Lioy, and M.E. Patarroyo Structure, immunogenicity, and protectivity relationship for the 1585 malarial peptide and its substitution analogues Angew. Chem. Int. Ed. 40 2001 4654 4657
7. R.A. Houghten General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids Proc. Natl. Acad. Sci. USA 82 1985 5131 5135
8. L.M. Salazar, M.P. Alba, M.H. Torres, M. Pinto, X. Cortes, L. Torres, and M.E. Patarroyo Protection against experimental malaria associated with AMA-1 peptide analogue structures FEBS Lett. 527 2002 95 100
9. R. Rodriguez, A. Moreno, F. Guzman, M. Calvo, and M.E. Patarroyo Studies in owl monkeys leading to the development of a synthetic vaccine against the asexual blood stages of Plasmodium falciparum Am. J. Trop. Med. Hyg. 43 1990 339 354
10. C. Lambros, and J.P. Vanderberg Synchronization of Plasmodium falciparum erythrocytic stages in culture J. Parasitol. 65 1979 418 420
11. F. Sinigaglia, P. Romagnoli, M. Guttinger, B. Takacs, and J.R. Pink Selection of T cell epitopes and vaccine engineering Methods Enzymol. 203 1991 370 386
12. L.E. Vargas, C.A. Parra, L.M. Salazar, F. Guzman, M. Pinto, and M.E. Patarroyo MHC allele-specific binding of a malaria peptide makes it become promiscuous on fitting a glycine residue into pocket 6 Biochem. Biophys. Res. Commun. 307 2003 148 156
13. D. Roccatano, G. Colombo, M. Fioroni, and A.E. Mark Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: a molecular dynamics study Proc. Natl. Acad. Sci. USA 99 2002 12179 12184
14. 1H NMR spectra of proteins via double quantum filtering Biochem. Biophys. Res. Commun. 117 1983 479 485
15. A. Bax, and D.G. Davis MLEV-17 based two dimensional homonuclear magnetization transfer spectroscopy J. Magn. Reson. 65 1985 355 360
16. J. Jeener, B.H. Meier, P. Backman, and R.R. Ernst Investigation of enhance processes by two dimensional NMR spectroscopy J. Chem. Phys. 71 1979 4546 4553
17. K. Wüthrich NMR of Proteins and Nucleic Acids 1986 Wiley New York
18. P. Ghosh, M. Amaya, E.D. Mellins, and C. Wiley The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3 Nature 378 1995 457 462
19. W. Kabsch, and G. Sander Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features Biopolymers 22 1983 2577 2637
20. J.J. Niño-Vásquez, D. Vogel, R. Rodríguez, A. Moreno, M.E. Patarroyo, G. Pluschke, and C.A. Daubenberger Sequence and diversity of DRB genes of Aotus nancymaae, a primate model for human malaria parasites Immunogenetics 51 2000 219 230
21. H.G. Rammensee, T. Friede, and S. Stevanoviic MHC ligands and peptide motifs: first listing Immunogenetics 41 1995 178 228
22. S.G. Marsh, P. Parham, and L.D. Barber The HLA facts Book 2000 Academic Press San Diego, CA pp. 334-361
23. H. Sing, and G.P. Raghava ProPred: prediction of HLA-DR binding sites Bioinformatics 17 2001 1236 1237
24. T.S. Jardetzky, J.H. Brown, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.C. Wiley Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides Proc. Natl. Acad. Sci. USA 93 1996 734 738