Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression

Journal of Molecular Endocrinology

Volumn 37, Issue 3, 2006, Pages 479-488

  Brothers, Shaun P ^a   Janovick, Jo Ann ^a   Conn, P Michael ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALNEXIN; GONADORELIN RECEPTOR; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CELL MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE MUTATION; HUMAN; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CALNEXIN; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; GENE EXPRESSION REGULATION; HUMANS; HYPOGONADISM; LIGANDS; LYSINE; MUTATION; PROTEIN BINDING; PROTEIN KINASE C; RATS; RECEPTORS, LHRH; RNA, SMALL INTERFERING;

EID: 33846123937     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.02142     Document Type: Article

References (38)

1. Allen S, Goodeve AC, Peake IR & Daly ME 2001 Endoplasmic reticulum retention and prolonged association of a von Willebrand's disease-causing von Willebrand factor variant with ERp57 and calnexin. Biochemical and Biophysical Research Communications 280 448-453.
2. Arora KK. Chung HO & Cart KJ 1999 Influence of a species-specific extracellular amino acid on expression and function of the human gonadotropin-releasing hormone receptor. Molecular Endocrinology 13 890-896.
3. Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB & Conn PM 2002 Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. Molecular and Cellular Endocrinology 190 19-27.
4. Brothers SP, Janovick JA & Conn PM 2003 Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. Journal of Clinical Endocrinology and Metabolism 88 6107-6112.
5. Brothers SP, Cornea A, Janovick JA & Conn PM 2004 Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Molecular Endocrinology 18 1787-1797.
6. Castro-Fernandez C, Janovick JA, Brothers SP, Fisher RA, Ji TH & Conn PM 2002 Regulation of RGS3 and RGS10 palmitoylation by GnRII. Endocrinology 143 1310-1317.
7. Castro-Fernandez C, Maya-Nunez G & Conn PM 2005 Beyond the signal sequence: protein routing in health and disease. Endocrine Reviews 26 479-503.
8. Conn PM, Janovick JA, Braden TD, Maurer RA & Jennes L 1992 SIIp: a unique secretogranin/chromogranin of the pituitary released in response to GnRH. Endocrinology 130 3033-3040.
9. Conn PM, Leanos-Miranda A & Janovick JA 2002 Protein origami: therapeutic rescue of misfolded gene products. Molecular Interventions 2 308-316.
10. Couzin J 2002 Protein structure. Harmless proteins twist into troublemakers. Science 296 28-29.
11. Davidson JS, Flanagan CA, Zhou W, Becker II, Elario R, Emeran W, Sealfon SC & Millar RP 1995 Identification of N-glycosylation sites in the gonadotropin-releasing hormone receptor: role in receptor expression but not ligand binding. Molecular and Cellular Endocrinology 107 241-245.
12. Ellgaard L & Frickel EM 2003 Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochemistry and Biophysics 39 223-247.
13. Firestone GL & Winguth SD 1990 Immunoprecipitation of proteins. Methods in Enzymology 182 688-700.
14. Gavel Y & von Heijne G 1990 Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineering. Protein Engineering 5 433-442.
15. Hebert DN, Foellmer B & Helenius A 1996 Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of infleuenza hemagglutinin in microsomes. EMBO Journal 15 2961-2968.
16. Huckle WR & Conn PM 1987 Use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover. Methods in Enzymology 141 149-155.
17. Janovick JA, Maya-Nunez G & Conn PM 2002 Rescue of hypogonadotropic-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. Journal of Clinical Endocrinology and Metabolism 87 3255-3266.
18. Janovick JA, Ulloa-Aguirre A & Conn PM 2003 Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression. Endocrine 22 317-327.
19. Janovick JA, Knollman PE, Brothers SP, Ayala-Yanez R, Aziz AS & Conn PM 2006 Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. Journal of Biological Chemistry 281 8417-8425.
20. Kleizen B & Braakman I 2004 Protein folding and quality control in the endoplasmic reticulum. Current Opinion in Cell Biology 16 343-349.
21. Klotz IM 1982 Numbers of receptor sites from Scatchard graphs: facts and fantasies. Science 217 1247-1249.
22. Knollman PE, Janovick JA, Brothers SP & Conn PM 2005 Parallel regulation of membrane trafficking and dominant-negative ellects by misrouted GnRH receptor mutants. Journal of Biological Chemistry 280 24506-24514.
23. Leanos-Miranda A, Ulloa-Aguirre A, Ji TH, Janovick JA & Conn PM 2003 Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. Journal of Clinical Endocrinology and Metabolism 88 3360-3367.
24. Lin X, Janovick JA, Brothers S, Blomenrohr M, Bogerd J & Conn PM 1998 Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Molecular Endocrinology 12 161-171.
25. Liu Y, Choudhury P, Cabral CM & Sifers RN 1999 Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. Journal of Biological Chemistry 274 5861-5867.
26. Maya-Nunez G, Janovick JA & Conn PM 2000 Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression. Endocrine 13 401-407.
27. Molinari M, Calanca V, Galli C, Lucca P & Paganetti P 2003 Role of EDEM in the release of misfolded glycoproteins from the calnexin. Science 299 1397-1400.
28. Oda Y, Hosokawa N, Wada I & Nagata K 2003 EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Science 299 1394-1397.
29. Roderick HL, Lechleiter JD & Camacho P 2000 Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b. Journal of Cell Biology 149 1235-1248.
30. Schrag JD, Procopio DO, Cygler M, Thomas DY & Bergeron JJ 2003 Lectin control of protein folding and sorting in the secretory pathway. Trends in Biochemical Sciences 28 49-57.
31. Scalfon SC, Weinstein H & Millar RP 1997 Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocrine Reviews 2 180-205.
32. Seminara SB, Hayes FJ & Crowley WF Jr 1998 Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallman's syndrome): pathophysiological and genetic considerations. Endocrine Reviews 19 521-539.
33. Tjoelker LW, Seyfried CE, Eddy RL Jr, Byers MG, Shows TB, Calderon J, Schreiber RB & Gray PW 1994 Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. Biochemistry 11 3229-3236.
34. Ulloa-Aguirre A, Janovick JA, Brothers SP & Conn PM 2004 Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic 5 821-837.
35. Vassilakos A, Michalak M, Lehrman MA & Williams DB 1998 Oligosaccharide binding characteristics of the molecular chaperones calnexin and calreticulin. Biochemistry 37 3480-3490.
36. Willars GB, Heding A, Vrecl M, Sellar R, Blomenrohr M, Nahorski SR & Eidne KA 1999 Lack of a C-terminal rail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization. Journal of Biological Chemistry 42 30146-30153.
37. Wong H-N, Ward MA, Bell AW, Chevet E, Bains S, Blackstock WP Solari R, Thomas DY & Bergeron JJ 1998 Conserved in vivo phosphorylation of calnexin at casein kinase II sites as well as a protein kinase C/ proline-directed kinase site. Journal of Biological Chemistry 27 17227-17235.
38. Zhu BT 1993 The competitive and noncompetitive antagonism of receptor-mediated drug actions in the presence of spare receptors. Journal of Pharmacological and Toxicological Methods 29 85-91.