Regulation of Glycogen Synthase Kinase-3 in Patients with Affective Disorders

Biological Psychiatry

Volumn 61, Issue 2, 2007, Pages 139-141

  O'Brien, W Timothy ^a   Klein, Peter S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3; INOSITOL PHOSPHATE; LITHIUM; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOGLUCOMUTASE; PROTEIN KINASE; PROTEIN KINASE C; PSYCHOTROPIC AGENT;

ARTICLE; BIPOLAR DISORDER; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; IC 50; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 33846110067     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.11.008     Document Type: Note

References (25)

1. Beasley C., Cotter D., and Everall I. An investigation of the Wnt-signalling pathway in the prefrontal cortex in schizophrenia, bipolar disorder and major depressive disorder. Schizophr Res 58 (2002) 63-67
2. Beaulieu J.M., Sotnikova T.D., Yao W.D., Kockeritz L., Woodgett J.R., Gainetdinov R.R., et al. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Natl Acad Sci U S A 101 (2004) 5099-5104
3. De Sarno P., Li X., and Jope R.S. Regulation of Akt and glycogen synthase kinase-3beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43 (2002) 1158-1164
4. Doble B.W., and Woodgett J.R. GSK-3: Tricks of the trade for a multi-tasking kinase. J Cell Sci 116 (2003) 1175-1186
5. Manic-Depressive Illness (1990), Oxford University Press, New York
6. Gould T.D., Einat H., Bhat R., and Manji H.K. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 7 (2004) 387-390
7. Gurvich N., and Klein P.S. Lithium and valproic acid: Parallels and contrasts in diverse signaling contexts. Pharmacol Ther 96 (2002) 45-66
8. Hedgepeth C., Conrad L., Zhang Z., Huang H., Lee V., and Klein P. Activation of the Wnt signaling pathway: A molecular mechanism for lithium action. Dev Biol 185 (1997) 82-91
9. Hsiung S.C., Adlersberg M., Arango V., Mann J.J., Tamir H., and Liu K.P. Attenuated 5-HT1A receptor signaling in brains of suicide victims: Involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. J Neurochem 87 (2003) 182-194
10. Ide M., Ohnishi T., Murayama M., Matsumoto I., Yamada K., Iwayama Y., et al. Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia. Cell 99 (2006) 277-287
11. Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126 (2006) 955-968
12. Kaidanovich-Beilin O., Milman A., Weizman A., Pick C.G., and Eldar-Finkelman H. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry 55 (2004) 781-784
13. Klein P.S., and Melton D.A. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93 (1996) 8455-8459
14. Kozlovsky N., Belmaker R.H., and Agam G. Low GSK-3 activity in frontal cortex of schizophrenic patients. Schizophr Res 52 (2001) 101-105
15. Lesort M., Greendorfer A., Stockmeier C., Johnson G.V., and Jope R.S. Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain. J Neural Transm 106 (1999) 1217-1222
16. Li X., Friedman A.B., Roh M.S., and Jope R.S. Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain. J Neurochem 92 (2005) 701-704
17. Li X., Zhu W., Roh M.S., Friedman A.B., Rosborough K., and Jope R.S. In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain. Neuropsychopharmacology 29 (2004) 1426-1431
18. McManus E.J., Sakamoto K., Armit L.J., Ronaldson L., Shapiro N., Marquez R., et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 24 (2005) 1571-1583
19. Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275 (1997) 1787-1790
20. Murphy D.L. Animal models for mania. In: Hanin I., and Usdin E. (Eds). Animal Models in Psychiatry and Neurology (1977), Pergammon Press, Oxford 211-223
21. O'Brien W.T., Harper A.D., Jove F., Woodgett J.R., Maretto S., Piccolo S., et al. Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24 (2004) 6791-6798
22. Schlesinger A., Shelton C.A., Maloof J.N., Meneghini M., and Bowerman B. Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev 13 (1999) 2028-2038
23. Stambolic V., Ruel L., and Woodgett J. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6 (1996) 1664-1668
24. York J.D., Ponder J.W., and Majerus P.W. Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. Proc Natl Acad Sci U S A 92 (1995) 5149-5153
25. Zhang F., Phiel C.J., Spece L., Gurvich N., and Klein P.S. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem 278 (2003) 33067-33077