PKPD model of interleukin-21 effects on thermoregulation in monkeys - Application and evaluation of stochastic differential equations

Pharmaceutical Research

Volumn 24, Issue 2, 2007, Pages 298-309

  Overgaard, Rune Viig ^a,b,c   Holford, Nick ^d   Rytved, Klaus A ^b   Madsen, Henrik ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Autocorrelation; Immunomodulation; PKPD model; SDE; Statistical model; Thermoregulation

Indexed keywords

INTERLEUKIN 21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORE TEMPERATURE; DRUG MECHANISM; HEAT LOSS; MALE; METABOLISM; MONKEY; NONHUMAN; PRIORITY JOURNAL; SIMULATION; STATISTICAL MODEL; STOCHASTIC MODEL; THERMOREGULATION;

ALGORITHMS; ANIMALS; BODY TEMPERATURE REGULATION; CIRCADIAN RHYTHM; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; FEVER; INTERLEUKINS; LIKELIHOOD FUNCTIONS; MACACA FASCICULARIS; MALE; METABOLISM; MODELS, STATISTICAL; RECEPTORS, DRUG; STOCHASTIC PROCESSES;

EID: 33846083306     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9143-x     Document Type: Article

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