Stochastic differential equations in NONMEM®: Implementation, application, and comparison with ordinary differential equations

Pharmaceutical Research

Volumn 22, Issue 8, 2005, Pages 1247-1258

  Tornøe, Christoffer W ^a,b,c   Overgaard, Rune V ^b   Agersø, Henrik ^a   Nielsen, Henrik A ^b   Madsen, Henrik ^b   Jonsson, E Niclas ^c  

^a Ferring Pharmaceuticals AS   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Degarelix; Extended Kalman Filter; NONMEM; Parameter tracking; Population PK PD modeling; Stochastic differential equations, systematic model development

Indexed keywords

DEGARELIX; GONADORELIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECOMPOSITION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; HUMAN; MATHEMATICAL COMPUTING; MULTICENTER STUDY; NOISE; PRIORITY JOURNAL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL; STOCHASTIC MODEL;

ALGORITHMS; ANTINEOPLASTIC AGENTS; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; HUMANS; INTESTINAL ABSORPTION; LINEAR MODELS; MALE; MODELS, STATISTICAL; NONLINEAR DYNAMICS; OLIGOPEPTIDES; PHARMACOKINETICS; PROSTATIC NEOPLASMS; RECEPTORS, LHRH; SOFTWARE; STOCHASTIC PROCESSES;

EID: 23844485993     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-5269-5     Document Type: Article

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