Cyclopenta[g]quinazolinone-based inhibitors of thymidylate synthase targeting α-folate receptor overexpressing tumours: synthetic approaches to 4-{N-[(6RS)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

Tetrahedron

Volumn 63, Issue 7, 2007, Pages 1537-1543

  Bavetsias, Vassilios ^a   Henderson, Elisa A ^a   McDonald, Edward ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Antifolates; Cyclopenta g quinazolinones; Dicobalt hexacarbonyl complex

Indexed keywords

4 [N (2 HYDROXYMETHYL 4 OXO 3,4,7,8 TETRAHYDRO 6H CYCLOPENTA[G]QUINAZOLIN 6 YL) N (PROP 2 YNYL)AMINO]BENZOIC ACID; BENZOIC ACID DERIVATIVE; FOLATE RECEPTOR; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CRYSTALLOGRAPHY; DRUG SYNTHESIS; GENE OVEREXPRESSION; GENE TARGETING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 33846083133     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.11.092     Document Type: Article

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