How do the atypical antipsychotics work?

Journal of Psychiatry and Neuroscience

Volumn 26, Issue 5, 2001, Pages 385-394

  Ananth, Jambur ^a   Burgoyne, Karl S ^a   Gadasalli, Rangaesh ^a   Aquino, Sandra ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DOPAMINE RECEPTOR; ENKEPHALIN; NEUROLEPTIC AGENT; NEUROTENSIN; OLANZAPINE; PROTEIN C FOS; QUETIAPINE; RISPERIDONE; SERTINDOLE; ZIPRASIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN REGION; CORRELATION ANALYSIS; DOPAMINERGIC SYSTEM; DRUG MECHANISM; ELECTROPHYSIOLOGY; LIMBIC CORTEX; MENTAL DISEASE; NONHUMAN; NUCLEUS ACCUMBENS; ONCOGENE C FOS; PROTEIN ANALYSIS; REVIEW; SCHIZOPHRENIA; TISSUE DISTRIBUTION;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; HUMANS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0035689556     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (94)

1. A functional effect of dopamine in the nucleus accumbens and in some other dopamine rich parts of the brain
2. Is it possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data?
3. Atypical antipsychotics, clozapine and sulpiride do not antagonize amphetamine-induced stereotyped locomotion
4. Olanzapine versus placebo and haloperidol: Acute phase results of the North American double-blind olanzapine trial
5. Effects of typical and atypical antipsychotic drugs on two-way active avoidance. Relationship to DA receptor blocking profile
6. Behavioral effects of sertindole, risperidone, clozapine and haloperidol in Cebus monkeys
7. Antagonism of the hyperactivity induced by dopamine applied intracerebrally to the nucleus accumbens septi by typical neuroleptics and by clozapine, sulpiride and thioridazine
8. Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: Evidence for two different mechanisms of action
9. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent
10. Survey on the pharmacodynamics of the new antipsychotic risperidone
11. The olfactory tubercle as a site of action of neuroleptics with an atypical profile in the paw test: Effect of risperidone, prothipendyl, ORG 5222, sertindole and olanzapine
12. Stimulus-transcription coupling in neurons: Role of cellular immediate-early genes
13. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
14. 2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
15. Induction of c-fos mRNA expression in rat striatum by neuroleptic drugs
16. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine
17. Neuroleptics increase c-fos expression in the forebrain: Contrasting effects of haloperidol and clozapine
18. 2 dopamine receptors differentially regulate c-fos expression in striatonigral and striatopallidal neurons
19. 2 receptor antagonists induced immediate early genes in the rat striatum
20. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum
21. Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum
22. Characterization of dopamine release in the substantia nigra by in vivo microdialysis in freely moving rats
23. Scopolamine attenuates haloperidol-induced c-fos expression in the striatum
24. Differential influence of haloperidol and sulpiride on dopamine receptors and peptide mRNA levels in rat striatum and pituitary
25. Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain
26. 2 receptor blockade project to the globus pallidus
27. 2 receptor: An immunohistochemical double-labeling study using antibodies against Fos
28. Morphology and Fos immunoreactivity reveal two subpopulations of striatal neurotensin neurons following acute 6-hydroxydopamine lesions and reserpine administration
29. Increase of neurotensin content elicited by neuroleptics in nucleus accumbens
30. C-fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum
31. Effects of short- and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the rat
32. The effects of typical and atypical antipsychotic drugs on neurotensin-containing neurons in the central nervous system
33. Alterations in [Met5]- and [Leu5]enkephalin and neurotensin content in basal ganglia induced by the long-term administration of dopamine agonist and antagonist drugs to rats
34. Differential effects of antipsychotic drugs on the neurotensin concentrations of discrete rat brain nuclei
35. Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra
36. Differential effects of antipsychotic and psycho-tomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions
37. The effects of sertindole on regional CNS neurotensin concentration in the rat brain
38. Atypical neuroleptic-like behavioral effects of neurotensin
39. Does neurotensin mediate the effects of antipsychotic drugs?
40. Coexpression of neurotensin and c-fos mRNAs in rat neostriatal neurons following acute haloperidol
41. Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs
42. The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat
43. Converging projections from the mediodorsal thalamic nucleus and mesencephalic dopaminergic neurons to the neocortex in three species
44. Restricted cortical termination fields of the midline and intralaminar nuclei in the rat
45. Inhibitory influence of the mesocortical dopaminergic system on spontaneous activity or excitatory response induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex
46. Anatomical and electrophysiological evidence for an excitatory amino acid pathway from the thalamic mediodorsal nucleus to the prefrontal cortex in the rat
47. Glutamatergic excitatory responses of anterior cingulate neurons to stimulation of the mediodorsal thalamus and their regulation by GABA: An in vivo iontophoretic study
48. Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain
49. Receptor mechanisms mediating clozapine-induced c-fos expression in the forebrain
50. Contributions of clinical neuropsychology to the study of schizophrenia
51. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A regional cerebral blood flow study of discordant monzygotic twins
52. Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
53. Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brain
54. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: A novel locus of antipsychotic drug action
55. 2 receptors in the medial prefrontal cortex: Microiontophoretic studies
56. Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action
57. Clinical and biologic response to clozapine in patients with schizophrenia: Crossover comparison with fluphenazine
58. i values
59. Neurobiological correlates of acute neuroleptic treatment
60. Serotonin dopamine interaction and its relevance in schizophrenia
61. 123I IBZM single photon emission tomography (SPET) study
62. 2 occupancy, clinical response, and side effects: A double-blind PET study of first-episode schizophrenia
63. 2 receptor occupancy of clozapine, respirodone, and olanzapine in schizophrenia
64. 2 receptors yet occupy high levels of these receptors
65. 3) as a target for neuroleptics
66. 3 receptors in rat brain
67. 3 dopamine receptors in rat brain and pituitary gland: A quantitative autoradiographic study
68. 4 receptor with high affinity for the antipsychotic clozapine
69. 3H]hydroxy-N,N-di-n-propyl-2-aminotetralin
70. 3-selective receptor ligand
71. 4 receptors
72. 4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs
73. 4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia
74. Striatal c-fos induction by cocaine or apomorphine occur preferentially in output neurons projecting to the substantia nigra in the rat
75. Differences in the regional and cellular localization of c-fos messenger RNA induced by amphetamine, cocaine and caffeine in the rat
76. 1 dopamine receptor gene
77. 1 dopamine receptor-deficient mouse: Cocaine-induced regulation of immediate-early gene and substance P expression in the striatum
78. 1 antagonist SCH 23390 in comparison with neuroleptics
79. 2-receptor antagonists induce catalepsy via different efferent striatal pathways
80. 2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment
81. 2 receptor occupancy: Implications for antipsychotic action
82. Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors
83. Role of serotonin in the action of atypical antipsychotic drugs
84. 2 receptor occupancy of olanzapine in schizophrenia: A PET investigation
85. Biochemical anatomy: Insights into the cell biology and pharmacology of neurotransmitter systems in the brain
86. Interactions of fluoxetine with metabolism of dopamine and serotonin in rat brain regions
87. Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: Involvement of alpha 1-noradrenergic receptors demonstrated by in vivo voltammetry
88. Prospects for pharmacotherapy of schizophrenia
89. Midbrain dopamine system electro-physiological functioning: A review and new hypothesis
90. Seroquel: Electrophysiological profile of a potential atypical antipsychotic
91. Electrophysiological profile of the new atypical neuroleptic sertindole on midbrain dopamine neurons in rats: Acute and repeated treatment
92. Possible mechanisms by which repeated clozapine administration diferentially affects the activity of two sub-populations of mid-brain dopamine neurons
93. 10 areas in rats following chronic treatment with different neuroleptic drugs
94. 2 receptors: Implications for atypical antipsychotic action