Improving cell therapy-experiments using transplanted telomerase-immortalized cells in immunodeficient mice

Mechanisms of Ageing and Development

Volumn 128, Issue 1, 2007, Pages 25-30

  Huang, Qin ^a,b   Chen, Meizhen ^a,b   Liang, Sitai ^a,b   Acha, Victor ^a,b   Liu, Dan ^a,b   Yuan, Furong ^a,b   Hawks, Christina L ^a,b   Hornsby, Peter J ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Cell therapy; hTERT; Immortalization; Immunodeficient mice; Mesenchymal cells

Indexed keywords

GLUCOCORTICOID; MINERALOCORTICOID; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ADRENAL CORTEX CELL; ADRENAL GLAND; ARTICLE; CARCINOGENESIS; CELL CLONE; CELL IMMORTALIZATION; CELL THERAPY; CELL TRANSPLANTATION; GENE EXPRESSION; IMMUNE DEFICIENCY; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; TISSUE STRUCTURE;

ANIMALS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; TELOMERASE;

ANIMALIA;

EID: 33846073153     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2006.11.006     Document Type: Article

References (53)

1. Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., and Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 10114-10118
2. Bhowmick N.A., Neilson E.G., and Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature 432 (2004) 332-337
3. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., and Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
4. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 (2005) 513-522
5. Cao B., Deasy B.M., Pollett J., and Huard J. Cell therapy for muscle regeneration and repair. Phys. Med. Rehabil. Clin. N. Am. 16 (2005) 889-907
6. Cerezo A., Stark H.J., Moshir S., and Boukamp P. Constitutive overexpression of human telomerase reverse transcriptase but not c-myc blocks terminal differentiation in human HaCaT skin keratinocytes. J. Invest. Dermatol. 121 (2003) 110-119
7. Cheng C.Y., Ryan R.F., Vo T.P., and Hornsby P.J. Cellular senescence involves stochastic processes causing loss of expression of differentiated function genes: transfection with SV40 as a means for dissociating effects of senescence on growth and on differentiated function gene expression. Exp. Cell Res. 180 (1989) 49-62
8. Cheng C.Y., Flasch M.V., and Hornsby P.J. Expression of 17α-hydroxylase and 3β-hydroxysteroid dehydrogenase in fetal human adrenocortical cells transfected with SV40 T antigen. J. Mol. Endocrinol. 9 (1992) 7-17
9. de Lange T., and DePinho R.A. Unlimited mileage from telomerase?. Science 283 (1999) 947-949
10. Dudognon C., Pendino F., Hillion J., Saumet A., Lanotte M., and Segal-Bendirdjian E. Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. Oncogene 23 (2004) 7469-7474
11. Forough R., Xi Z., MacPhee M., Friedman S., Engleka K.A., Sayers T., Wiltrout R.H., and Maciag T. Differential transforming abilities of non-secreted and secreted forms of human fibroblast growth factor-1. J. Biol. Chem. 268 (1993) 2960-2968
12. Funk W.D., Wang C.K., Shelton D.N., Harley C.B., Pagon G.D., and Hoeffler W.K. Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model. Exp. Cell Res. 258 (2000) 270-278
13. Giovanella B.C., Stehlin Jr. J.S., Shepard R.C., and Williams Jr. L.J. Correlation between response to chemotherapy of human tumors in patients and in nude mice. Cancer 52 (1983) 1146-1152
14. Greider C.W. Telomeres, telomerase and senescence. Bioessays 12 (1990) 363-369
15. Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., and Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature 400 (1999) 464-468
16. Harley C.B. Telomere loss: mitotic clock or genetic time bomb?. Mutat. Res. 256 (1991) 271-282
17. Harley C.B., Futcher A.B., and Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345 (1990) 458-460
18. Hayflick L. Cell aging. Annu. Rev. Gerontol. Geriatr. 1 (1980) 26-67
19. Hornsby P.J. Cell proliferation in mammalian aging. In: Masoro E.J., and Austad S.N. (Eds). Handbook of the Biology of Aging (2001), Academic Press, San Diego 207-266
20. Hornsby P.J. Telomerization of mammalian cells and transplantation of telomerized cells in immunodeficient mice. In: Sgaramella V., and Eridani S. (Eds). Mammalian Artificial Chromosomes: Methods and Protocols (2004), Humana, Totowa, NJ 147-166
21. Jiang X.R., Jimenez G., Chang E., Frolkis M., Kusler B., Sage M., Beeche M., Bodnar A.G., Wahl G.M., Tlsty T.D., and Chiu C.P. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet. 21 (1999) 111-114
22. Joseph N.M., and Morrison S.J. Toward an understanding of the physiological function of mammalian stem cells. Dev. Cell 9 (2005) 173-183
23. Klinger R.Y., Blum J.L., Hearn B., Lebow B., and Niklason L.E. Relevance and safety of telomerase for human tissue engineering. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 2500-2505
24. Masutomi K., Possemato R., Wong J.M., Currier J.L., Tothova Z., Manola J.B., Ganesan S., Lansdorp P.M., Collins K., and Hahn W.C. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8222-8227
25. Montini E., Cesana D., Schmidt M., Sanvito F., Ponzoni M., Bartholomae C., Sergi L.S., Benedicenti F., Ambrosi A., Di Serio C., Doglioni C., von Kalle C., and Naldini L. Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat. Biotechnol. 24 (2006) 687-696
26. Morales C.P., Holt S.E., Ouellette M., Kaur K.J., Yan Y., Wilson K.S., White M.A., Wright W.E., and Shay J.W. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet. 21 (1999) 115-118
27. Murry C.E., Reinecke H., and Pabon L.M. Regeneration gaps: observations on stem cells and cardiac repair. J. Am. Coll. Cardiol. 47 (2006) 1777-1785
28. O'Connor T.P., and Crystal R.G. Genetic medicines: treatment strategies for hereditary disorders. Nat. Rev. Genet. 7 (2006) 261-276
29. Oh H., Taffet G.E., Youker K.A., Entman M.L., Overbeek P.A., Michael L.H., and Schneider M.D. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 10308-10313
30. Park I.K., Morrison S.J., and Clarke M.F. Bmi1, stem cells, and senescence regulation. J. Clin. Invest. 113 (2004) 175-179
31. Perrault S.D., Hornsby P.J., and Betts D.H. Global gene expression response to telomerase in bovine adrenocortical cells. Biochem. Biophys. Res. Commun. 335 (2005) 925-936
32. Pirzio L.M., Freulet-Marriere M.A., Bai Y., Fouladi B., Murnane J.P., Sabatier L., and Desmaze C. Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation. Cytogenet. Genome Res. 104 (2004) 87-94
33. Popnikolov N.K., and Hornsby P.J. Subcutaneous transplantation of bovine and human adrenocortical cells in collagen gel in scid mice. Cell Transplant. 8 (1999) 617-625
34. Povlsen C.O., Skakkebaek N.E., Rygaard J., and Jensen G. Heterotransplantation of human foetal organs to the mouse mutant nude. Nature 248 (1974) 247-249
35. Rahman R., Latonen L., and Wiman K.G. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 24 (2005) 1320-1327
36. Rubio M.A., Kim S.H., and Campisi J. Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J. Biol. Chem. 277 (2002) 28609-28617
37. Rubio M.A., Davalos A.R., and Campisi J. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp. Cell Res. 298 (2004) 17-27
38. Serrano A.L., and Andres V. Telomeres and cardiovascular disease: does size matter?. Circ. Res. 94 (2004) 575-584
39. Shay J.W., and Wright W.E. The use of telomerized cells for tissue engineering. Nat. Biotechnol. 18 (2000) 22-23
40. Smith L.L., Coller H.A., and Roberts J.M. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat. Cell Biol. 5 (2003) 474-479
41. Sun B., Huang Q., Liu S., Chen M., Hawks C.L., Wang L., Zhang C., and Hornsby P.J. Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptase. Cancer Res. 64 (2004) 6144-6151
42. Sun B., Chen M., Hawks C.L., Pereira-Smith O.M., and Hornsby P.J. The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia 7 (2005) 585-593
43. + human cells do not require telomerase reverse transcriptase for malignant transformation. Cancer Res. 65 (2005) 6512-6515
44. Sung Y.H., Choi Y.S., Cheong C., and Lee H.W. The pleiotropy of telomerase against cell death. Mol. Cells 19 (2005) 303-309
45. Suwa T., Yang L., and Hornsby P.J. Telomerase activity in primary cultures of normal adrenocortical cells. J. Endocrinol. 170 (2001) 677-684
46. Thomas M., and Hornsby P.J. Transplantation of primary bovine adrenocortical cells into scid mice. Mol. Cell. Endocrinol. 153 (1999) 125-136
47. Thomas M., Northrup S.R., and Hornsby P.J. Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands. Nat. Med. 3 (1997) 978-983
48. Thomas M., Yang L., and Hornsby P.J. Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat. Biotechnol. 18 (2000) 39-42
49. Thomas M., Wang X., and Hornsby P.J. Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiency. Xenotransplantation 9 (2002) 58-67
50. Thomas M., Suwa T., Yang L., Zhao L., Hawks C.L., and Hornsby P.J. Cooperation of hTERT, SV40 T antigen and oncogenic Ras in tumorigenesis: a cell transplantation model using bovine adrenocortical cells. Neoplasia 4 (2002) 493-500
51. Ulaner G.A. Telomere maintenance in clinical medicine. Am. J. Med. 117 (2004) 262-269
52. Weinberg R.A. Telomeres. Bumps on the road to immortality. Nature 396 (1998) 23-24
53. Yang L., Suwa T., Wright W.E., Shay J.W., and Hornsby P.J. Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells. Mech. Ageing Dev. 122 (2001) 1685-1694