메뉴 건너뛰기




Volumn 81, Issue 2, 2007, Pages 791-799

Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT;

EID: 33846069213     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00714-06     Document Type: Article
Times cited : (9)

References (52)
  • 2
    • 0028147382 scopus 로고
    • ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures
    • Bolovan, C. A., N. M. Sawtell, and R. L. Thompson. 1994. ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J. Virol. 68:48-55.
    • (1994) J. Virol , vol.68 , pp. 48-55
    • Bolovan, C.A.1    Sawtell, N.M.2    Thompson, R.L.3
  • 3
    • 18144416539 scopus 로고    scopus 로고
    • Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells
    • Campbell, S., J. Lin, E. Dobrikova, and M. Gromeier. 2005. Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells. J. Virol. 79:6281-6290.
    • (2005) J. Virol , vol.79 , pp. 6281-6290
    • Campbell, S.1    Lin, J.2    Dobrikova, E.3    Gromeier, M.4
  • 4
    • 0028970730 scopus 로고
    • Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1
    • Chou, J., J. J. Chen, M. Gross, and B. Roizman. 1995. Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 92:10516-10520.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10516-10520
    • Chou, J.1    Chen, J.J.2    Gross, M.3    Roizman, B.4
  • 5
    • 0025688373 scopus 로고
    • Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture
    • Chou, J., E. R. Kern, R. J. Whitley, and B. Roizman. 1990. Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science 250:1262-1266.
    • (1990) Science , vol.250 , pp. 1262-1266
    • Chou, J.1    Kern, E.R.2    Whitley, R.J.3    Roizman, B.4
  • 6
    • 0026539149 scopus 로고
    • The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
    • Chou, J., and B. Roizman. 1992. The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc. Natl. Acad. Sci. USA 89:3266-3270.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3266-3270
    • Chou, J.1    Roizman, B.2
  • 7
    • 0022655615 scopus 로고
    • The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component
    • Chou, J., and B. Roizman. 1986. The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component. J. Virol. 57:629-637.
    • (1986) J. Virol , vol.57 , pp. 629-637
    • Chou, J.1    Roizman, B.2
  • 8
    • 0344303621 scopus 로고    scopus 로고
    • Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3′ nontranslated region
    • Dobrikova, E., P. Florez, S. Bradrick, and M. Gromeier. 2003. Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3′ nontranslated region. Proc. Natl. Acad. Sci. USA 100:15125-15130.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15125-15130
    • Dobrikova, E.1    Florez, P.2    Bradrick, S.3    Gromeier, M.4
  • 9
    • 33645214412 scopus 로고    scopus 로고
    • Competitive translation efficiency at the picornavirus type 1 internal ribosomal entry site facilitated by viral cis and trans factors
    • Dobrikova, E., R. Grisham, J. Lin, and M. Gromeier. 2006. Competitive translation efficiency at the picornavirus type 1 internal ribosomal entry site facilitated by viral cis and trans factors. J. Virol. 80:3310-3321.
    • (2006) J. Virol , vol.80 , pp. 3310-3321
    • Dobrikova, E.1    Grisham, R.2    Lin, J.3    Gromeier, M.4
  • 10
    • 4544380237 scopus 로고    scopus 로고
    • A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice
    • Dufresne, A. T., and M. Gromeier. 2004. A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. Proc. Natl. Acad. Sci. USA 101:13636-13641.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13636-13641
    • Dufresne, A.T.1    Gromeier, M.2
  • 11
    • 0020356106 scopus 로고
    • Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex
    • Etchison, D., S. C. Milburn, I. Edery, N. Sonenberg, and J. W. Hershey. 1982. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J. Biol. Chem. 257:14806-14810.
    • (1982) J. Biol. Chem , vol.257 , pp. 14806-14810
    • Etchison, D.1    Milburn, S.C.2    Edery, I.3    Sonenberg, N.4    Hershey, J.W.5
  • 12
    • 22544452431 scopus 로고    scopus 로고
    • mRNA decay during herpes simplex virus (HSV) infections: Protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A
    • Feng, P., D. N. Everly, Jr., and G. S. Read. 2005. mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. J. Virol. 79:9651-9664.
    • (2005) J. Virol , vol.79 , pp. 9651-9664
    • Feng, P.1    Everly Jr., D.N.2    Read, G.S.3
  • 13
    • 0034796322 scopus 로고    scopus 로고
    • mRNA decay during herpesvirus infections: Interaction between a putative viral nuclease and a cellular translation factor
    • Feng, P., D. N. Everly, Jr., and G. S. Read. 2001. mRNA decay during herpesvirus infections: interaction between a putative viral nuclease and a cellular translation factor. J. Virol. 75:10272-10280.
    • (2001) J. Virol , vol.75 , pp. 10272-10280
    • Feng, P.1    Everly Jr., D.N.2    Read, G.S.3
  • 14
    • 0028908299 scopus 로고
    • Isolation, characterization, and use of stem cells from the CNS
    • Gage, F. H., J. Ray, and L. J. Fisher. 1995. Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 18:159-192.
    • (1995) Annu. Rev. Neurosci , vol.18 , pp. 159-192
    • Gage, F.H.1    Ray, J.2    Fisher, L.J.3
  • 15
    • 0032486317 scopus 로고    scopus 로고
    • Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
    • Geraghty, R. J., C. Krummenacher, G. H. Cohen, R. J. Eisenberg, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280:1618- 1620.
    • (1998) Science , vol.280 , pp. 1618-1620
    • Geraghty, R.J.1    Krummenacher, C.2    Cohen, G.H.3    Eisenberg, R.J.4    Spear, P.G.5
  • 16
    • 0029864009 scopus 로고    scopus 로고
    • Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants
    • Gromeier, M., L. Alexander, and E. Wimmer. 1996. Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc. Natl. Acad. Sci. USA 93:2370-2375.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2370-2375
    • Gromeier, M.1    Alexander, L.2    Wimmer, E.3
  • 17
    • 0032935027 scopus 로고    scopus 로고
    • Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence
    • Gromeier, M., B. Bossert, M. Arita, A. Nomoto, and E. Wimmer. 1999. Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. J. Virol. 73:958-964.
    • (1999) J. Virol , vol.73 , pp. 958-964
    • Gromeier, M.1    Bossert, B.2    Arita, M.3    Nomoto, A.4    Wimmer, E.5
  • 19
    • 0031017382 scopus 로고    scopus 로고
    • 1597. The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
    • He, B., M. Gross, and B. Roizman. 1597. The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 94:843-848.
    • Proc. Natl. Acad. Sci. USA , vol.94 , pp. 843-848
    • He, B.1    Gross, M.2    Roizman, B.3
  • 20
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland, E. C., J. Celestino, C. Dai, L. Schaefer, R. E. Sawaya, and G. N. Fuller. 2000. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 25:55-57.
    • (2000) Nat. Genet , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 22
    • 0023758546 scopus 로고
    • A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation
    • Jang, S. K., H. G. Krausslich, M. J. Nicklin, G. M. Duke, A. C. Palmenberg, and E. Wimmer. 1988. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62:2636-2643.
    • (1988) J. Virol , vol.62 , pp. 2636-2643
    • Jang, S.K.1    Krausslich, H.G.2    Nicklin, M.J.3    Duke, G.M.4    Palmenberg, A.C.5    Wimmer, E.6
  • 23
    • 0032889314 scopus 로고    scopus 로고
    • Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro
    • Joachims, M., P. C. Van Breugel, and R. E. Lloyd. 1999. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J. Virol. 73:718-727.
    • (1999) J. Virol , vol.73 , pp. 718-727
    • Joachims, M.1    Van Breugel, P.C.2    Lloyd, R.E.3
  • 24
    • 16844366956 scopus 로고    scopus 로고
    • An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor
    • Kambara, H., H. Okano, E. A. Chiocca, and Y. Saeki. 2005. An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. 65:2832-2839.
    • (2005) Cancer Res , vol.65 , pp. 2832-2839
    • Kambara, H.1    Okano, H.2    Chiocca, E.A.3    Saeki, Y.4
  • 25
    • 29944447647 scopus 로고    scopus 로고
    • Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence
    • Kanai, R., H. Tomita, A. Shinoda, M. Takahashi, S. Goldman, H. Okano, T. Kawase, and T. Yazaki. 2006. Enhanced therapeutic efficacy of G207 for the treatment of glioma through Musashi1 promoter retargeting of gamma34.5-mediated virulence. Gene Ther. 13:106-116.
    • (2006) Gene Ther , vol.13 , pp. 106-116
    • Kanai, R.1    Tomita, H.2    Shinoda, A.3    Takahashi, M.4    Goldman, S.5    Okano, H.6    Kawase, T.7    Yazaki, T.8
  • 26
    • 0031881772 scopus 로고    scopus 로고
    • A neuroattenuated ICP34.5-deficient herpes simplex virus type 1 replicates in ependymal cells of the murine central nervous system
    • Kesari, S., T. M. Lasner, K. R. Balsara, B. P. Randazzo, V. M. Lee, J. Q. Trojanowski, and N. W. Fraser. 1998. A neuroattenuated ICP34.5-deficient herpes simplex virus type 1 replicates in ependymal cells of the murine central nervous system. J. Gen. Virol. 79:525-536.
    • (1998) J. Gen. Virol , vol.79 , pp. 525-536
    • Kesari, S.1    Lasner, T.M.2    Balsara, K.R.3    Randazzo, B.P.4    Lee, V.M.5    Trojanowski, J.Q.6    Fraser, N.W.7
  • 28
    • 0029876445 scopus 로고    scopus 로고
    • Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function
    • Lam, Q., C. A. Smibert, K. E. Koop, C. Lavery, J. P. Capone, S. P. Weinheimer, and J. R. Smiley. 1996. Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. EMBO J. 15:2575-2581.
    • (1996) EMBO J , vol.15 , pp. 2575-2581
    • Lam, Q.1    Smibert, C.A.2    Koop, K.E.3    Lavery, C.4    Capone, J.P.5    Weinheimer, S.P.6    Smiley, J.R.7
  • 29
    • 2642671979 scopus 로고    scopus 로고
    • 134.5 transcripts and latency-associated transcripts
    • 134.5 transcripts and latency-associated transcripts. J. Virol. 72:4250-4264.
    • (1998) J. Virol , vol.72 , pp. 4250-4264
    • Lee, L.Y.1    Schaffer, P.A.2
  • 30
    • 0024693747 scopus 로고
    • Definition of an efficient synthetic poly(A) site
    • Levitt, N., D. Briggs, A. Gil, and N. J. Proudfoot. 1989. Definition of an efficient synthetic poly(A) site. Genes Dev. 3:1019-1025.
    • (1989) Genes Dev , vol.3 , pp. 1019-1025
    • Levitt, N.1    Briggs, D.2    Gil, A.3    Proudfoot, N.J.4
  • 31
    • 0035168426 scopus 로고    scopus 로고
    • The vhs1 mutant form of herpes simplex virus virion host shutoff protein retains significant internal ribosome entry site-directed RNA cleavage activity
    • Lu, P., H. A. Saffran, and J. R. Smiley. 2001. The vhs1 mutant form of herpes simplex virus virion host shutoff protein retains significant internal ribosome entry site-directed RNA cleavage activity. J. Virol. 75:1072-1076.
    • (2001) J. Virol , vol.75 , pp. 1072-1076
    • Lu, P.1    Saffran, H.A.2    Smiley, J.R.3
  • 35
    • 0024519677 scopus 로고
    • Cellular receptor for poliovirus: Molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily
    • Mendelsohn, C. L., E. Wimmer, and V. R. Racaniello. 1989. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56:855-865.
    • (1989) Cell , vol.56 , pp. 855-865
    • Mendelsohn, C.L.1    Wimmer, E.2    Racaniello, V.R.3
  • 37
    • 33645229489 scopus 로고    scopus 로고
    • Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA binding protein 76
    • Merrill, M. K., E. Dobrikova, and M. Gromeier. 2006. Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA binding protein 76. J. Virol. 80:3147-3156.
    • (2006) J. Virol , vol.80 , pp. 3147-3156
    • Merrill, M.K.1    Dobrikova, E.2    Gromeier, M.3
  • 38
    • 33745778659 scopus 로고    scopus 로고
    • The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosomal entry site
    • Merrill, M. K., and M. Gromeier. 2006. The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosomal entry site. J. Virol. 80:6936-6942.
    • (2006) J. Virol , vol.80 , pp. 6936-6942
    • Merrill, M.K.1    Gromeier, M.2
  • 39
    • 27944484930 scopus 로고    scopus 로고
    • To replicate or not to replicate: Achieving selective oncolytic virus replication in cancer cells through translational control
    • Mohr, I. 2005. To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control. Oncogene 24:7697-7709.
    • (2005) Oncogene , vol.24 , pp. 7697-7709
    • Mohr, I.1
  • 40
    • 0029841340 scopus 로고    scopus 로고
    • A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function
    • Mohr, I., and Y. Gluzman. 1996. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J. 15:4759-4766.
    • (1996) EMBO J , vol.15 , pp. 4759-4766
    • Mohr, I.1    Gluzman, Y.2
  • 41
    • 0035036952 scopus 로고    scopus 로고
    • A herpes simplex virus type 1 γ34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals
    • Mohr, I., D. Sternberg, S. Ward, D. Leib, M. Mulvey, and Y. Gluzman. 2001. A herpes simplex virus type 1 γ34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals. J. Virol. 75:5189-5196.
    • (2001) J. Virol , vol.75 , pp. 5189-5196
    • Mohr, I.1    Sternberg, D.2    Ward, S.3    Leib, D.4    Mulvey, M.5    Gluzman, Y.6
  • 42
    • 0141566327 scopus 로고    scopus 로고
    • Regulation of eIF2α phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle
    • Mulvey, M., J. Poppers, D. Sternberg, and I. Mohr. 2003. Regulation of eIF2α phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle. J. Virol. 77:10917-10928.
    • (2003) J. Virol , vol.77 , pp. 10917-10928
    • Mulvey, M.1    Poppers, J.2    Sternberg, D.3    Mohr, I.4
  • 44
    • 33644782770 scopus 로고    scopus 로고
    • Targeted therapy of human glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus
    • Ochiai, H., S. Campbell, G. E. Archer, T. A. Chewning, E. Dragunsky, A. Ivanov, M. Gromeier, and J. H. Sampson. 2006. Targeted therapy of human glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus. Clin. Cancer Res. 12:1349-1354.
    • (2006) Clin. Cancer Res , vol.12 , pp. 1349-1354
    • Ochiai, H.1    Campbell, S.2    Archer, G.E.3    Chewning, T.A.4    Dragunsky, E.5    Ivanov, A.6    Gromeier, M.7    Sampson, J.H.8
  • 45
    • 0023720048 scopus 로고
    • Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
    • Pelletier, J., and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334:320-325.
    • (1988) Nature , vol.334 , pp. 320-325
    • Pelletier, J.1    Sonenberg, N.2
  • 46
    • 2342595872 scopus 로고    scopus 로고
    • Postgenomic global analysis of translational control induced by oncogenic signaling
    • Rajasekhar, V. K., and E. C. Holland. 2004. Postgenomic global analysis of translational control induced by oncogenic signaling. Oncogene 23:3248-3264.
    • (2004) Oncogene , vol.23 , pp. 3248-3264
    • Rajasekhar, V.K.1    Holland, E.C.2
  • 47
    • 0242361561 scopus 로고    scopus 로고
    • Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
    • Rajasekhar, V. K., A. Viale, N. D. Socci, M. Wiedmann, X. Hu, and E. C. Holland. 2003. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell 12:889-901.
    • (2003) Mol. Cell , vol.12 , pp. 889-901
    • Rajasekhar, V.K.1    Viale, A.2    Socci, N.D.3    Wiedmann, M.4    Hu, X.5    Holland, E.C.6
  • 49
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds, B. A., and S. Weiss. 1992. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 51
    • 33644552729 scopus 로고    scopus 로고
    • The UL41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins
    • Taddeo, B., W. Zhang, and B. Roizman. 2006. The UL41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins. Proc. Natl. Acad. Sci. USA 193:2827-2832.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.193 , pp. 2827-2832
    • Taddeo, B.1    Zhang, W.2    Roizman, B.3
  • 52
    • 0035902471 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
    • Taneja, S., J. MacGregor, S. Markus, S. Ha, and I. Mohr. 2001. Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells. Proc. Natl. Acad. Sci. USA 98:8804-8808.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8804-8808
    • Taneja, S.1    MacGregor, J.2    Markus, S.3    Ha, S.4    Mohr, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.