In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 2, 2007, Pages 301-304

  Nicoll Griffith, Deborah A ^a   Seto, Carmai ^a   Aubin, Yves ^a   Lévesque, Jean François ^a   Chauret, Nathalie ^a   Day, Stephen ^a   Silva, José M ^a   Trimble, Laird A ^a   Truchon, Jean François ^a   Berthelette, Carl ^a   Lachance, Nicolas ^a   Wang, Zhaoyin ^a   Sturino, Claudio ^a   Braun, Matt ^b   Zamboni, Robert ^a   Young, Robert N ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biotransformations; DP receptor antagonist; Metabolites; MK 0524; Reactive intermediates

Indexed keywords

DRUG METABOLITE; GLUCURONIDE; KETONE; MK 0524; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; COVALENT BOND; DIASTEREOISOMER; DRUG DOSE TITRATION; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; INDOLES; MACACA MULATTA; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; OXIDATION-REDUCTION; PROSTAGLANDIN D2; RABBITS; RATS; SAIMIRI; SHEEP; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33846065949     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.055     Document Type: Article

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