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Volumn 837, Issue 1-2, 2006, Pages 116-124
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Determination of a prostaglandin D2 antagonist and its acyl glucuronide metabolite in human plasma by high performance liquid chromatography with tandem mass spectrometric detection-A lack of MS/MS selectivity between a glucuronide conjugate and a phase I metabolite
a
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Author keywords
LC MS MS; Prostaglandin D2 antagonist
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Indexed keywords
ATMOSPHERIC PRESSURE;
CARBOXYLIC ACIDS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
IONIZATION;
MASS SPECTROMETRY;
ORGANIC POLYMERS;
PLASMAS;
ANALYTE CONCENTRATIONS;
GLUCURONIDE METABOLITE;
LC-MS/MS;
PROSTAGLANDIN D2 ANTAGONIST;
METABOLITES;
DRUG METABOLITE;
FORMIC ACID;
GLUCURONIDE;
PROSTAGLANDIN D2;
PROSTAGLANDIN D2 ANTAGONIST;
PROSTAGLANDIN RECEPTOR BLOCKING AGENT;
UNCLASSIFIED DRUG;
ARTICLE;
DRUG DETERMINATION;
DRUG HYDROLYSIS;
DRUG ISOLATION;
DRUG SELECTIVITY;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
MASS SPECTROMETRY;
PRIORITY JOURNAL;
ROOM TEMPERATURE;
SENSITIVITY ANALYSIS;
SOLID PHASE EXTRACTION;
STATISTICAL SIGNIFICANCE;
TANDEM MASS SPECTROMETRY;
AUTOMATION;
BLOOD;
CHEMISTRY;
DRUG ANTAGONISM;
METHODOLOGY;
REPRODUCIBILITY;
SENSITIVITY AND SPECIFICITY;
SPECTROFLUOROMETRY;
STANDARD;
ULTRAVIOLET SPECTROPHOTOMETRY;
VALIDATION STUDY;
AUTOMATION;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
GLUCURONIDES;
HUMANS;
MASS SPECTROMETRY;
PROSTAGLANDIN ANTAGONISTS;
PROSTAGLANDIN D2;
REFERENCE STANDARDS;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, FLUORESCENCE;
SPECTROPHOTOMETRY, ULTRAVIOLET;
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EID: 33646861753
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2006.04.022 Document Type: Article |
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Times cited : (21)
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References (10)
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