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We are aware of the fact that orthogonality in truth means that the two glycosides participating in a glycosylation event can be used as either donor or acceptor at will, depending on the conditions applied. Here we use the word orthogonal in accordance with common practice in synthetic carbohydrate chemistry, namely, to indicate that a donor glycoside (here hemiacetal 23) is condensed with an acceptor glycoside (thiouronic ester 9) which has an anomeric functional group that can be activated in its own right allowing a second glycosylation event (here condensation with acceptor 25) without the necessity of intermediate functional group manipulations. As such the orthogonal glycosylation strategy is complementary to the so-called chemoselective glycosylation in which both donor and acceptor have the same anomeric functionality. See for a comparison: J. D. C. Codée, R. E. J. N. Litjens, L. J. van den Bos, H. S. Overkleeft, G. A. van der Marel
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