Antiangiogenic antithrombin blocks the heparan sulfate-dependent binding of proangiogenic growth factors to their endothelial cell receptors: Evidence for differential binding of antiangiogenic and anticoagulant forms of antithrombin to proangiogenic heparan sulfate domains

Journal of Biological Chemistry

Volumn 281, Issue 49, 2006, Pages 37302-37310

  Zhang, Weiqing ^a   Swanson, Richard ^a   Xiong, Yan ^a   Richard, Benjamin ^a   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; DIMERIZATION; ENZYME INHIBITION; GROWTH KINETICS; SULFATE MINERALS; TERNARY SYSTEMS;

CELL RECEPTORS; FIBROBLAST GROWTH FACTOR (FGF); VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

CELL MEMBRANES;

ANTITHROMBIN; FIBROBLAST GROWTH FACTOR 2; HEPARAN SULFATE; HEPARIN LYASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SERINE PROTEINASE INHIBITOR; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANGIOGENESIS INHIBITORS; ANTICOAGULANTS; ANTITHROMBINS; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTORS; HEPARIN; HEPARIN LYASE; HEPARITIN SULFATE; HUMANS; PROTEIN BINDING; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33846025442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604905200     Document Type: Article

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