-
1
-
-
0031455114
-
Antithrombin, a bloody important serpin
-
Church FC, Cunningham DD, Ginsburg D, Hoffman M, Stone SR, Tollefsen DM, eds. New York, NY: Plenum Press
-
Björk I, Olson ST. Antithrombin, a bloody important serpin. In: Church FC, Cunningham DD, Ginsburg D, Hoffman M, Stone SR, Tollefsen DM, eds. Chemistry and Biology of Serpins. New York, NY: Plenum Press; 1997:17-33.
-
(1997)
Chemistry and Biology of Serpins
, pp. 17-33
-
-
Björk, I.1
Olson, S.T.2
-
2
-
-
0036882395
-
Serpin structure, mechanism, and function
-
Gettins PGW. Serpin structure, mechanism, and function. Chem Rev. 2002;102:4751-4803.
-
(2002)
Chem Rev
, vol.102
, pp. 4751-4803
-
-
Gettins, P.G.W.1
-
3
-
-
0036021104
-
Identification of critical molecular interactions mediating heparin activation of antithrombin: Implications for the design of improved heparin anticoagulants
-
Olson ST, Björk I, Bock SC. Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants. Trends Cardiovasc Med. 2002;12:198-205.
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 198-205
-
-
Olson, S.T.1
Björk, I.2
Bock, S.C.3
-
4
-
-
0036872229
-
Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases
-
Olson ST, Chuang Y-J. Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases. Trends Cardiovasc Med. 2002;12:331-338.
-
(2002)
Trends Cardiovasc Med
, vol.12
, pp. 331-338
-
-
Olson, S.T.1
Chuang, Y.-J.2
-
5
-
-
0036625064
-
Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells
-
Oelschläger C, Römisch J, Staubitz A, et al. Antithrombin III inhibits nuclear factor κB activation in human monocytes and vascular endothelial cells. Blood. 2002;99:4015-4020.
-
(2002)
Blood
, vol.99
, pp. 4015-4020
-
-
Oelschläger, C.1
Römisch, J.2
Staubitz, A.3
-
6
-
-
0036830549
-
Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor
-
Geiben-Lynn R, Brown N, Walker BD, Luster AD. Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor. J Biol Chem. 2002;277:42352-42357.
-
(2002)
J Biol Chem
, vol.277
, pp. 42352-42357
-
-
Geiben-Lynn, R.1
Brown, N.2
Walker, B.D.3
Luster, A.D.4
-
7
-
-
0033578910
-
Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
-
O'Reilly MS, Pirie-Shepherd S, Lane WS, Folkman J. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science. 1999;285:1926-1928.
-
(1999)
Science
, vol.285
, pp. 1926-1928
-
-
O'Reilly, M.S.1
Pirie-Shepherd, S.2
Lane, W.S.3
Folkman, J.4
-
8
-
-
0034544536
-
Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells
-
Larsson H, Sjöblom T, Dixelius J, et al. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Cancer Res. 2000;60:6723-6729.
-
(2000)
Cancer Res
, vol.60
, pp. 6723-6729
-
-
Larsson, H.1
Sjöblom, T.2
Dixelius, J.3
-
9
-
-
0035853699
-
A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity
-
Larsson H, Åkerud P, Nordling K, Raub-Segall E, Claesson-Welsh L, Björk I. A novel anti-angiogenic form of antithrombin with retained proteinase binding ability and heparin affinity. J Biol Chem. 2001;276:11996-12002.
-
(2001)
J Biol Chem
, vol.276
, pp. 11996-12002
-
-
Larsson, H.1
Åkerud, P.2
Nordling, K.3
Raub-Segall, E.4
Claesson-Welsh, L.5
Björk, I.6
-
10
-
-
0035476261
-
Generation of multiple angiogenesis inhibitors by human pancreatic cancer
-
Kisker O, Onizuka S, Banyard J, et al. Generation of multiple angiogenesis inhibitors by human pancreatic cancer. Cancer Res. 2001;61:7298-7304.
-
(2001)
Cancer Res
, vol.61
, pp. 7298-7304
-
-
Kisker, O.1
Onizuka, S.2
Banyard, J.3
-
11
-
-
0027259312
-
Crystal structure of cleaved bovine antithrobin III at 3.2 Å resolution
-
Mourey L, Samama JP, Delarue M, Petitou M, Choay J, Moras D. Crystal structure of cleaved bovine antithrobin III at 3.2 Å resolution. J Mol Biol. 1993;232:223-241.
-
(1993)
J Mol Biol
, vol.232
, pp. 223-241
-
-
Mourey, L.1
Samama, J.P.2
Delarue, M.3
Petitou, M.4
Choay, J.5
Moras, D.6
-
12
-
-
0031588685
-
The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site
-
Skinner R, Abrahams J-P, Whisstock JC, Lesk AM, Carrell RW, Wardell MR. The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site. J Mol Biol. 1997;266:601-609.
-
(1997)
J Mol Biol
, vol.266
, pp. 601-609
-
-
Skinner, R.1
Abrahams, J.-P.2
Whisstock, J.C.3
Lesk, A.M.4
Carrell, R.W.5
Wardell, M.R.6
-
13
-
-
0030700799
-
Preparative induction and characterization of L-antithrombin: A structural homologue of latent plasminogen activator inhibitor-1
-
Wardell MR, Chang WSW, Bruce D, Skinner R, Lesk AM, Carrell RW. Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1. Biochemistry. 1997;36:13133-13142.
-
(1997)
Biochemistry
, vol.36
, pp. 13133-13142
-
-
Wardell, M.R.1
Chang, W.S.W.2
Bruce, D.3
Skinner, R.4
Lesk, A.M.5
Carrell, R.W.6
-
14
-
-
0020359205
-
Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin
-
Björk I, Fish WW, Production in vitro and properties of a modified form of bovine antithrombin, cleaved at the active site by thrombin. J Biol Chem. 1982;257:9487-9493.
-
(1982)
J Biol Chem
, vol.257
, pp. 9487-9493
-
-
Björk, I.1
Fish, W.W.2
-
15
-
-
0029866947
-
Probing serpin reactive-loop conformations by proteolytic cleavage
-
Chang W, Wardell M, Lomas D, Carrell R. Probing serpin reactive-loop conformations by proteolytic cleavage. Biochem J. 1996;314:647-653.
-
(1996)
Biochem J
, vol.314
, pp. 647-653
-
-
Chang, W.1
Wardell, M.2
Lomas, D.3
Carrell, R.4
-
16
-
-
0033608984
-
Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A
-
Stratikos E, Gettins PGW. Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A. Proc Natl Acad Sci U S A. 1999;96:4808-4813.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4808-4813
-
-
Stratikos, E.1
Gettins, P.G.W.2
-
17
-
-
0034687422
-
Structure of a serpin-protease complex shows inhibition by deformation
-
Huntington JA, Read RJ, Carrell RW. Structure of a serpin-protease complex shows inhibition by deformation. Nature. 2000;407:923-926.
-
(2000)
Nature
, vol.407
, pp. 923-926
-
-
Huntington, J.A.1
Read, R.J.2
Carrell, R.W.3
-
18
-
-
0019371304
-
Thrombin-induced proteolysis of human antithrombin III: An outstanding contribution of heparin
-
Marciniak E. Thrombin-induced proteolysis of human antithrombin III: an outstanding contribution of heparin. Br J Haematol. 1981;48:325-336.
-
(1981)
Br J Haematol
, vol.48
, pp. 325-336
-
-
Marciniak, E.1
-
19
-
-
0033570979
-
Formation of the antithrombin heterodimer in vivo and the onset of thrombosis
-
Zhou A, Huntington JA, Carrell RW. Formation of the antithrombin heterodimer in vivo and the onset of thrombosis. Blood. 1999;94:3388-3396.
-
(1999)
Blood
, vol.94
, pp. 3388-3396
-
-
Zhou, A.1
Huntington, J.A.2
Carrell, R.W.3
-
20
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9:653-660.
-
(2003)
Nat Med
, vol.9
, pp. 653-660
-
-
Carmeliet, P.1
-
21
-
-
0032823523
-
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
-
Pollack JR, Perou CM, Alizadeh AA, et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet. 1999;23:41-46.
-
(1999)
Nat Genet
, vol.23
, pp. 41-46
-
-
Pollack, J.R.1
Perou, C.M.2
Alizadeh, A.A.3
-
22
-
-
0028579734
-
Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis
-
Aviezer D, Hecht D, Safran M, Eisinger M, David G, Yayon A, Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell. 1994;79:1005-1013.
-
(1994)
Cell
, vol.79
, pp. 1005-1013
-
-
Aviezer, D.1
Hecht, D.2
Safran, M.3
Eisinger, M.4
David, G.5
Yayon, A.6
-
23
-
-
0030945178
-
Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA
-
Aviezer D, Iozzo RV, Noonan DM, Yayon A. Suppression of autocrine and paracrine functions of basic fibroblast growth factor by stable expression of perlecan antisense cDNA. Mol Cell Biol. 1997;17:1938-1946.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1938-1946
-
-
Aviezer, D.1
Iozzo, R.V.2
Noonan, D.M.3
Yayon, A.4
-
24
-
-
0027498670
-
Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin
-
Olson ST, Björk I, Shore JD. Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin. Methods Enzymol. 1993;222:525-560.
-
(1993)
Methods Enzymol
, vol.222
, pp. 525-560
-
-
Olson, S.T.1
Björk, I.2
Shore, J.D.3
-
25
-
-
0022389299
-
Heparin and ionic strength-dependent conversion of antithrombin III from an inhibitor to a substrate of alpha-thrombin
-
Olson ST. Heparin and ionic strength-dependent conversion of antithrombin III from an inhibitor to a substrate of alpha-thrombin. J Biol Chem. 1985;260:10153-10160.
-
(1985)
J Biol Chem
, vol.260
, pp. 10153-10160
-
-
Olson, S.T.1
-
26
-
-
0035941340
-
Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding
-
Arocas V, Bock SC, Raja SM, Olson ST, Björk I. Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding. J Biol Chem. 2001;276:43809-43817.
-
(2001)
J Biol Chem
, vol.276
, pp. 43809-43817
-
-
Arocas, V.1
Bock, S.C.2
Raja, S.M.3
Olson, S.T.4
Björk, I.5
-
27
-
-
0015822275
-
Culture of human endothelial cells derived from umbilical veins: Identification by morphologic and immunologic criteria
-
Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745-2756.
-
(1973)
J Clin Invest
, vol.52
, pp. 2745-2756
-
-
Jaffe, E.A.1
Nachman, R.L.2
Becker, C.G.3
Minick, C.R.4
-
28
-
-
0034682892
-
Genes expressed in human tumor endothelium
-
St. Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science. 2000;289:1197-1202.
-
(2000)
Science
, vol.289
, pp. 1197-1202
-
-
St. Croix, B.1
Rago, C.2
Velculescu, V.3
-
29
-
-
0037249405
-
The Stanford Microarray Database: Data access and quality assessment tools
-
Gollub J, Ball CA, Binkley G, et al. The Stanford Microarray Database: data access and quality assessment tools. Nucleic Acids Res. 2003;31:94-96.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 94-96
-
-
Gollub, J.1
Ball, C.A.2
Binkley, G.3
-
31
-
-
0026758187
-
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan): A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor
-
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan): a chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J Biol Chem. 1992;267:8544-8557.
-
(1992)
J Biol Chem
, vol.267
, pp. 8544-8557
-
-
Murdoch, A.D.1
Dodge, G.R.2
Cohen, I.3
Tuan, R.S.4
Iozzo, R.V.5
-
32
-
-
0021154990
-
Immunoblotting and dot immunobinding: Current status and outlook
-
Towbin H, Gordon J. Immunoblotting and dot immunobinding: current status and outlook. J Immunol Methods. 1984;72:313-340.
-
(1984)
J Immunol Methods
, vol.72
, pp. 313-340
-
-
Towbin, H.1
Gordon, J.2
-
33
-
-
0034904186
-
Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena
-
Iozzo RV, San Antonio JD. Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest. 2001;108:349-355.
-
(2001)
J Clin Invest
, vol.108
, pp. 349-355
-
-
Iozzo, R.V.1
San Antonio, J.D.2
-
34
-
-
0033954774
-
Cell-density-dependent regulation of proteoglycan synthesis by transforming growth factor-β1 in cultured bovine aortic endothelial cells
-
Kaji T, Yamada A, Miyajima S, et al. Cell-density-dependent regulation of proteoglycan synthesis by transforming growth factor-β1 in cultured bovine aortic endothelial cells. J Biol Chem. 2000;275:1463-1470.
-
(2000)
J Biol Chem
, vol.275
, pp. 1463-1470
-
-
Kaji, T.1
Yamada, A.2
Miyajima, S.3
-
35
-
-
3643129096
-
Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo
-
Sharma B, Handler M, Eichstetter I, Whitelock JM, Nugent MA, Iozzo RV. Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest. 1998;102:1599-1608.
-
(1998)
J Clin Invest
, vol.102
, pp. 1599-1608
-
-
Sharma, B.1
Handler, M.2
Eichstetter, I.3
Whitelock, J.M.4
Nugent, M.A.5
Iozzo, R.V.6
-
36
-
-
0031462263
-
Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA
-
Adatia R, Albini A, Carlone S, et al. Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA. Ann Oncol. 1997;8:1257-1261.
-
(1997)
Ann Oncol
, vol.8
, pp. 1257-1261
-
-
Adatia, R.1
Albini, A.2
Carlone, S.3
-
37
-
-
0033615959
-
Perlecan maintains the integrity of cartilage and some basement membranes
-
Costell M, Gustafsson E, Aszodi A, et al. Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999;147:1109-1122.
-
(1999)
J Cell Biol
, vol.147
, pp. 1109-1122
-
-
Costell, M.1
Gustafsson, E.2
Aszodi, A.3
-
38
-
-
0032726952
-
Perlecan is essential for cartilage and cephalic development
-
Ankawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y. Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999;23:354-358.
-
(1999)
Nat Genet
, vol.23
, pp. 354-358
-
-
Ankawa-Hirasawa, E.1
Watanabe, H.2
Takami, H.3
Hassell, J.R.4
Yamada, Y.5
-
39
-
-
0033570910
-
Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin
-
Sasaki T, Larsson H, Kreuger J, et al. Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin. EMBO J. 1999;18:6240-6248.
-
(1999)
EMBO J
, vol.18
, pp. 6240-6248
-
-
Sasaki, T.1
Larsson, H.2
Kreuger, J.3
-
40
-
-
18744394907
-
Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function
-
Kreuger J, Matsumoto T, Vanwildemeersch M, et al. Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function. EMBO J. 2002;21:6303-6311.
-
(2002)
EMBO J
, vol.21
, pp. 6303-6311
-
-
Kreuger, J.1
Matsumoto, T.2
Vanwildemeersch, M.3
-
41
-
-
0026690347
-
Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions: Resolution of the antithrombin conformational change contribution to heparin rate enhancement
-
Olson ST, Björk I, Sheffer R, Craig PA, Shore, JD, Choay J. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions: resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem. 1992;267:12528-12538.
-
(1992)
J Biol Chem
, vol.267
, pp. 12528-12538
-
-
Olson, S.T.1
Björk, I.2
Sheffer, R.3
Craig, P.A.4
Shore, J.D.5
Choay, J.6
-
42
-
-
0026733347
-
Cell surface heparan sulfate proteoglycans from human vascular endothelial cells: Core protein characterization and antithrombin III binding properties
-
Mertens G, Cassiman JJ, Van Den Berghe H, Vermylen J, David G. Cell surface heparan sulfate proteoglycans from human vascular endothelial cells: core protein characterization and antithrombin III binding properties. J Biol Chem. 1992;267:20435-20443.
-
(1992)
J Biol Chem
, vol.267
, pp. 20435-20443
-
-
Mertens, G.1
Cassiman, J.J.2
Van Den Berghe, H.3
Vermylen, J.4
David, G.5
|