Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients

American Journal of Physiology - Endocrinology and Metabolism

Volumn 292, Issue 1, 2007, Pages

  Cardellini, Marina ^a   Marini, Maria Adelaide ^a   Frontoni, Simona ^a   Hribal, Marta Letizia ^b   Andreozzi, Francesco ^b   Perticone, Francesco ^a   Federici, Massimo ^a   Lauro, Davide ^a   Sesti, Giorgio ^b,c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c Policlinico Mater Domini   (Italy)

Author keywords

Atherosclerosis; Inflammation; Insulin sensitivity; Plasma insulin levels; White blood cell count

Indexed keywords

FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 6; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRY; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CIGARETTE SMOKING; CLINICAL FEATURE; COMMON CAROTID ARTERY; CONTROLLED STUDY; DEMOGRAPHY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; FEMALE; GLUCOSE TOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATCH CLAMP; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; UNIVARIATE ANALYSIS; WAIST CIRCUMFERENCE;

ADULT; ADULT CHILDREN; ATHEROSCLEROSIS; BLOOD GLUCOSE; BLOOD PRESSURE; CAROTID ARTERY, COMMON; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; METABOLISM; MIDDLE AGED; TUNICA MEDIA;

EID: 33846011371     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00291.2006     Document Type: Article

References (52)

1. Agewall S, Fagerbern B, Attvall S, Wendelhag I, Urbanavicius V, Wikstrand J. Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in men at high and low coronary risk. Stroke 26: 956-960, 1995.
2. Balletshofer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S, Matthaei S, Rett K, Haring HU. Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation 101: 1780-1784, 2000.
3. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96: 939-949, 2005.
4. Cardellini M, Perego L, D'Adamo M, Marini MA, Procopio C, Hribal ML, Andreozzi F, Frontoni S, Giacomelli M, Paganelli M, Pontiroli AE, Lauro R, Folli F, Sesti G. C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diabetes Care 28: 2007-2012, 2005.
5. Chapman CM, Beilby JP, McQuillan BM, Thompson PL, Hung J. Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke 35: 1619-1624, 2004.
6. Collins VR, Dowse GK, Zimmet PZ, Tuomilehto J, Alberti KG, Gareeboo H, Nan L. Serum insulin and ECG abnormalities suggesting coronary heart disease in the populations of Mauritius and Nauru: cross-sectional and longitudinal associations. J Clin Epidemiol 46: 1373-1393, 1993.
7. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334: 952-957, 1996.
8. Elkind MS, Cheng J, Boden-Albala B, Paik MC, Sacco RL. Elevated white blood cell count and carotid plaque thickness: The Northern Manhattan Stroke Study. Stroke 32: 842-849, 2001.
9. Facchini F, Hollenbeck CB, Chen YN, Chen YD, Reaven HM. Demonstration of a relationship between white blood cell count, insulin resistance, and several risk factors for coronary heart disease in women. J Intern Med 232: 267-272, 1992.
10. Ferrara A, Barrett-Connor EL, Edelstein SL. Hyperinsulinemia does not increase the risk of fatal cardiovascular disease in elderly men or women without diabetes: the Rancho Bernardo Study, 1984-1991. Am J Epidemiol 140: 857-869, 1994.
11. Festa A, D'Agostino R, Howard G, Mykkanen L, Tracey RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 101: 42-47, 2000.
12. Folsom AR, Pankow JS, Tracy RP, Arnett DK, Peacock JM, Hong Y, Djousse L, Eckfeldt JH. Association of C-reactive protein with markers of prevalent atherosclerotic disease. Am J Cardiol 88: 112-117, 2001.
13. Folsom AR, Szklo M, Stevens J, Liao F, Smith R, Eckfeldt JH. A prospective study of coronary heart disease in relation to fasting insulin, glucose, and diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 20: 935-942, 1997.
14. Fontbonne A, Charles MA, Thibult N, Richard JL, Claude JR, Warnet JM, Rosselin GE, Eschwege E. Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up. Diabetologia 34: 356-361, 1981.
15. 14a. Genuth S, Albert KG, Bennett P, Buse J, Defronzo R, Kahn R, Kitzmiller J, Knowler WC, Lebovitz H, Lernmark A, Nathan D, Palmer J, Rizza R, Saudek C, Shaw J, Steffes M, Stern M, Tuomilehto J, Zimmet P. Follow-up report on the diagnosis of diabetes mellitus. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 26: 3160-3167, 2003.
16. Grundy SM. Obesity, metabolic syndrome, and coronary atherosclerosis. Circulation 105: 2696-2698, 2002.
17. Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Increased insulin concentrations in nondiabetic offspring of diabetic parents. N Engl J Med 319: 1297-1301, 1998.
18. Hanley AJ, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 25: 1177-1184, 2002.
19. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R. Insulin sensitivity and atherosclerosis. Circulation 93: 1809-1817, 1996.
20. Hu G, Qiao Q, Tuomilehto J, Eliasson M, Feskens EJ, Pyorala K. DECODE Insulin Study Group: Plasma insulin and cardiovascular mortality in non-diabetic European men and women: a meta-analysis of data from eleven prospective studies. Diabetologia 47: 1245-1256, 2004.
21. Huang ZS, Jeng JS, Wang CH, Yip PK, Wu TH, Lee TK. Correlations between peripheral differential leukocyte counts and carotid atherosclerosis in non-smokers. Atherosclerosis 158: 431-436, 2001.
22. Hunt ME, O'Malley PG, Vernalis MN, Feuerstein IM, Taylor AJ. C-reactive protein is not associated with the presence or extent of calcified subclinical atherosclerosis. Am Heart J 141: 206-210, 2001.
23. Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal. joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28: 2289-2304, 2005.
24. Kannel WB, Anderson K, Wilson PW. White blood cell count and cardiovascular disease. Insights from the Framingham Study. JAMA 267: 1253-1256, 1992.
25. Laakso M, Sarlund H, Salonen R, Suhonen M, Pyörälä K, Salonen JT, Karhapää P. Asymptomatic atherosclerosis and insulin resistance. Arterioscler Thromb 11: 1068-1076, 1991.
26. Larsson H, Berglund G, Ahreh B. Insulin sensitivity, insulin secretion, and glucose tolerance versus intima-media thickness in nondiabetic postmenopausal women. J Clin Endocrinol Metab 88: 4791-4797, 2003.
27. Lempiäinen P, Mykkänen L, Pyörälä K, Laakso M, Kuusisto J. Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 100: 123-128, 1999.
28. Lindahl B, Dinesen B, Eliasson M, Roder M, Jansson JH, Huhtasaari F, Hallmans G. High proinsulin concentration precedes acute myocardial infarction in a nondiabetic population. Metabolism 48: 1197-1202, 1999.
29. Lindberg O, Tilvis RS, Strandberg TE, Valvanne J, Sairanen S, Ehnholm C, Tuomilehto J. Elevated fasting plasma insulin in a general aged population: an innocent companion of cardiovascular diseases. J Am Geriatr Soc 45: 407-412, 1997.
30. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 82: 4196-4200, 1997.
31. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106: 3143-3421, 2002.
32. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340: 14-22, 1999.
33. Pannacciulli N, De Pergola G, Ciccone M, Rizzon P, Giorgino F, Giorgino R. Effect of family history of type 2 diabetes on the intimamedia thickness of the common carotid artery in normal-weight, overweight, and obese glucose-tolerant young adults. Diabetes Care 26: 1230-1234, 2003.
34. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27: 813-823, 2004.
35. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall. A direct measurement with ultrasound imaging. Circulation 74: 1399-1406, 1986.
36. Pyörälä K. Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 2: 131-141, 1979.
37. Pyorala M, Miettinen H, Laakso M, Pyorala K. Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Circulation 98: 398-404, 1998.
38. Reaven GM. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
39. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342: 836-843, 2000.
40. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentrations of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101: 1767-1772, 2000.
41. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 340: 115-126, 1999.
42. Sarlund H, Pyorala K, Penttila I, Laakso M. Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin dependent diabetes. Arterioscler Thromb 12: 657-663, 1992.
43. Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 106: 171-176, 2000.
44. Sitzer M, Markus HS, Mendall MA, Liehr R, Knorr U, Steinmetz H. C-reactive protein and carotid intimal medial thickness in a community population. J Cardiovasc Risk 9: 97-103, 2002.
45. Suzuki M, Shinozaki K, Kanazawa A, Hara Y, Hattori Y, Tsushima M, Harano Y. Insulin resistance as an independent risk factor for carotid wall thickening. Hypertension 28: 593-598, 1996.
46. Temelkova-Kurktschiev T, Koehler C, Henkel E, Hanefeld M. Leukocyte count and fibrinogen are associated with carotid and femoral intima-media thickness in a risk population for diabetes. Cardiovasc Res 56: 277-83, 2002.
47. Tracy RP, Psaty BM, Macy E, Bovill EG, Cushman M, Cornell ES, Kuller LH. Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol 17: 2167-2176, 1997.
48. Van de Meer IM, de Maat M, Bots ML, Breteler MMB, Meijer J, Kiliaan AJ, Hofman A, Witteman JC. Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis. The Rotterdam Study. Stroke 33: 2750-2755, 2002.
49. Welin L, Eriksson H, Larsson B, Ohlson LO, Svardsudd K, Tibblin G. Hyperinsulinemia is not a major coronary risk factor in elderly men: the study of men born in 1913. Diabetologia 35: 766-770, 1992.
50. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112: 1785-1788, 2003.
51. Yarnell JWG, Baker IA, Sweetnam PM, Bainton D, O'Brien JR, Whitehead PJ, Elwood PC. Fibrinogen, viscosity and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Circulation 83: 836-844, 1991.
52. Yip J, Facchini FS, Reaven GM. Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 83: 2773-2776, 1998.