Chronic vitamin A status and acute repletion with retinyl palmitate are determinants of the distribution and catabolism of all-trans-retinoic acid in rats

Journal of Nutrition

Volumn 137, Issue 1, 2007, Pages 63-70

  Cifelli, Christopher J ^a   Ross, A Catharine ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYP26A1 ENZYME; CYTOCHROME P450; DRUG METABOLITE; MESSENGER RNA; RETINOIC ACID; RETINOL; RETINOL PALMITATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; FEMALE; ISOTOPE LABELING; LUNG; NONHUMAN; NUTRITIONAL STATUS; ORGAN WEIGHT; RAT; RETINOL DEFICIENCY; SINGLE DRUG DOSE; SMALL INTESTINE; VITAMIN BLOOD LEVEL;

EID: 33846010118     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.1.63     Document Type: Article

References (60)

1. Dowling JE, Wald G. The role of vitamin A acid. Vitam Horm. 1960;18:515-41.
2. Keilson B, Underwood BA, Loerch JD. Effects of retinoic acid on the mobilization of vitamin A from the liver in rats. J Nutr. 1979;109:787-95.
3. Cifelli CJ, Green JB, Green MH. Dietary retinoic acid alters vitamin A kinetics in both the whole body and in specific organs of rats with low vitamin A status. J Nutr. 2005;135:746-52.
4. Ross AC, Harrison EH. Vitamin A and Carotenoids. In: McCormick DB, Rucker RR, Suttie JW, Zempleni J, editors. Handbook of Vitamins, 4th ed. Boca Raton: Dekker/CRC Press; 2006.
5. Napoli JL. Retinoic acid: its biosynthesis and metabolism. Prog Nucleic Acid Res Mol Biol. 1999;63:139-88.
6. Varma RN, Beaton GH. Quantitative aspects of the urinary and fecal excretion of radioactive metabolites of vitamin A in the rat. Can J Physiol Pharmacol. 1972;50:1026-37.
7. Green MH, Green JB, Lewis KC. Variation in retinol utilization rate with vitamin A status in the rat. J Nutr. 1987;117:694-703.
8. Green MH, Uhl L, Green JB. A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores. J Lipid Res. 1985;26:806-18.
9. Lewis KC, Green MH, Green JB, Zech LA. Retinol metabolism in rats with low vitamin A status: a compartmental model. J Lipid Res. 1990;31:1535-48.
10. Green MH, Green JB. The application of model-based compartmental analysis to the study of kinetic behavior of vitamin A in vitamin A-sufficient rats: validation of a theoretical model. In: Hargrove JL, Berdanier CD, editors. Mathematical modeling in nutrition and toxicology. Athens: Biology Press; 2005. p. 175-87.
11. Goodman DS. Vitamin A and retinoids in health and disease. N Engl J Med. 1984;310:1023-31.
12. Gudas LJ, Sporn MB, Roberts AB. Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS, editors. The Retinoids: Biology, Chemistry, and Medicine, 2nd ed. New York: Raven Press; 1994. p. 443-520.
13. Peck GL, DiGiovanna JJ. Synthetic retinoids in dermatology. In: In: Sporn MB, Roberts AB, Goodman DS, editors. The Retinoids: Biology, Chemistry, and Medicine, 2nd ed. New York: Raven Press; 1994. p. 631-58.
14. Jimenez-Lara AM, Clarke N, Altucci L, Gronemeyer H. Retinoic-acid-induced apoptosis in leukemia cells. Trends Mol Med. 2004;10:508-15.
15. Ortega JJ, Madero L, Martin G, Verdeguer A, Garcia P, Parody R, Fuster J, Molines A, Novo A, et al. Treatment with all-trans retinoic acid and anthracycline monochemotherapy for children with acute promyelocytic leukemia: a multicenter study by the PETHEMA Group. J Clin Oncol. 2005;23:7632-40.
16. Okuno M, Kojima S, Matsushima-Nishiwaki R, Tsurumi H, Muto Y, Friedman SL, Moriwaki H. Retinoids in cancer chemoprevention. Curr Cancer Drug Targets. 2004;4:285-98.
17. Ma Y, Ross AC. The anti-tetanus immune response of neonatal mice is augmented by retinoic acid combined with polyriboinosinic:polyribocytidylic acid. Proc Natl Acad Sci USA. 2005;102:13556-61.
18. Ma Y, Chen Q, Ross AC. Retinoic acid and polyriboinosinic: polyribocytidylic acid stimulate robust anti-tetanus antibody production while differentially regulating type 1/type 2 cytokines and lymphocyte populations. J Immunol. 2005;174:7961-9.
19. Sommer A, Tarwotjo I, Djunaedi E, West KP, Jr., Loeden AA, Tilden R, Mele L. Impact of vitamin A supplementation on childhood mortality. A randomised controlled community trial. Lancet. 1986;1:1169-73.
20. Sommer A, West KP, Jr. In: Vitamin A deficiency: health, survival, and vision. Oxford University Press, Inc., New York. 1996.
21. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr. 2000;71:878-84.
22. Ross AC, Zolfaghari R. Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J Nutr. 2004;134:269S-75S.
23. Gardner EM, Ross AC. Dietary vitamin A restriction produces marginal vitamin A status in young rats. J Nutr. 1993;123:1435-43.
24. Reeves PG, Rossow KL, Lindlauf J. Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr. 1993;123:1923-31.
25. Cifelli CJ, Ross AC. All-trans-retinoic acid distribution and metabolism in vitamin A-marginal rats. Am J Physiol Gastrointest Liver Physiol. 2006;291:G195-202.
26. Dunagin PE, Jr., Meadows EH, Jr., Olson JA. Retinoyl beta-glucuronic acid: a major metabolite of vitamin A in rat bile. Science. 1965;148:86-7.
27. Roberts AB, DeLuca HF. Pathways of retinol and retinoic acid metabolism in the rat. Biochem J. 1967;102:600-5.
28. Kurlandsky SB, Gamble MV, Ramakrishnan R, Blaner WS. Plasma delivery of retinoic acid to tissues in the rat. J Biol Chem. 1995;270:17850-7.
29. Disdier B, Bun H, Catalin J, Durand A. Simultaneous determination of all-trans-, 13-cis-, 9-cis-retinoic acid and their 4-oxo-metabolites in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996;683:143-54.
30. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497-509.
31. Folch J, Ascoli I, Lees M, Meath JA, Le BN. Preparation of lipide extracts from brain tissue. J Biol Chem. 1951;191:833-41.
32. Frolik CA, Roberts AB, Tavela TE, Roller PP, Newton DL, Sporn MB. Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver. Biochemistry. 1979;18:2092-7.
33. Roberts AB, Frolik CA, Nichols MD, Sporn MB. Retinoid-dependent induction of the in vivo and in vitro metabolism of retinoic acid in tissues of the vitamin A-deficient hamster. J Biol Chem. 1979;254:6303-9.
34. Ross AC. Separation and quantitation of retinyl esters and retinol by high-performance liquid chromatography. Methods Enzymol. 1986;123:68-74.
35. Yamamoto Y, Zolfaghari R, Ross AC. Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats. FASEB J. 2000;14:2119-27.
36. Adamson PC. Clinical and pharmacokinetic studies of all-trans-retinoic acid in pediatric patients with cancer. Leukemia. 1994;8:1813-6.
37. Adamson PC. Pharmacokinetics of all-trans-retinoic acid: clinical implications in acute promyelocytic leukemia. Semin Hematol. 1994;31:14-7.
38. Smith MA, Adamson PC, Balis FM, Feusner J, Aronson L, Murphy RF, Horowitz ME, Reaman G, Hammond GD, et al. Phase I and pharmacokinetic evaluation of all-trans-retinoic acid in pediatric patients with cancer. J Clin Oncol. 1992;10:1666-73.
39. Regazzi MB, Iacona I, Gervasutti C, Lazzarino M, Toma S. Clinical pharmacokinetics of tretinoin. Clin Pharmacokinet. 1997;32:382-402.
40. Skare KL, DeLuca HF. Biliary metabolites of all-trans-retinoic acid in the rat. Arch Biochem Biophys. 1983;224:13-8.
41. Nagy NE, Holven KB, Roos N, Senoo H, Kojima N, Norum KR, Blomhoff R. Storage of vitamin A in extrahepatic stellate cells in normal rats. J Lipid Res. 1997;38:645-58.
42. Ross AC. Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic Acid oxidation. J Nutr. 2003;133:291S-6S.
43. Lampen A, Meyer S, Arnhold T, Nau H. Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes. J Pharmacol Exp Ther. 2000;295:979-85.
44. Rosales FJ, Ross AC. Acute inflammation induces hyporetinemia and modifies the plasma and tissue response to vitamin A supplementation in marginally vitamin A-deficient rats. J Nutr. 1998;128:960-6.
45. Zolfaghari R, Ross AC. Lecithin:retinol acyltransferase from mouse and rat liver. cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid. J Lipid Res. 2000;41:2024-34.
46. Wang Y, Zolfaghari R, Ross AC. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys. 2002;401:235-43.
47. Harrison EH, Blaner WS, Goodman DS, Ross AC. Subcellular localization of retinoids, retinoid-binding proteins, and acyl-CoA:retinol acyltransferase in rat liver. J Lipid Res. 1987;28:973-81.
48. Boerman MH, Napoli JL. Cholate-independent retinyl ester hydrolysis. Stimulation by Apo-cellular retinol-binding protein. J Biol Chem. 1991;266:22273-8.
49. Posch KC, Boerman MH, Burns RD, Napoli JL. Holocellular retinol binding protein as a substrate for microsomal retinal synthesis. Biochemistry. 1991;30:6224-30.
50. Herr FM, Ong DE. Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. Biochemistry. 1992;31:6748-55.
51. Swanson BN, Frolik CA, Zaharevitz DW, Roller PP, Sporn MB. Dose-dependent kinetics of all-trans-retinoic acid in rats. Plasma levels and excretion into bile, urine, and faeces. Biochem Pharmacol. 1981;30:107-13.
52. White JA, Guo YD, Baetz K, Beckett-Jones B, Bonasoro J, Hsu KE, Dilworth FJ, Jones G, Petkovich M. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. J Biol Chem. 1996;271:29922-7.
53. White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem. 1997;272:18538-41.
54. Boylan JF, Gudas LJ. The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells. J Biol Chem. 1992;267:21486-91.
55. Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr. 2001;21:167-92.
56. Scrimshaw NS, Taylor CE, Gordon JE. Interactions of nutrition and infection. WHO monograph series no. 57. Geneva, Switzerland: World Health Organization; 1968.
57. Sommer A. Mortality associated with mild, untreated xerophthalmia. Trans Am Ophthalmol Soc. 1983;81:825-53.
58. Sommer A, Tarwotjo I, Hussaini G, Susanto D. Increased mortality in children with mild vitamin A deficiency. Lancet. 1983;2:585-8.
59. Pasatiempo AM, Taylor CE, Ross AC. Vitamin A status and the immune response to pneumococcal polysaccharide: effects of age and early stages of retinol deficiency in rats. J Nutr. 1991;121:556-62.
60. Penniston KL, Tanumihardjo SA. Elevated serum concentrations of beta-glucuronide metabolites and 4-oxoretinol in lactating sows after treatment with vitamin A: a model for evaluating supplementation in lactating women. Am J Clin Nutr. 2005;81:851-8.