Dietary retinoic acid alters vitamin A kinetics in both the whole body and in specific organs of rats with low vitamin A status

Journal of Nutrition

Volumn 135, Issue 4, 2005, Pages 746-752

  Cifelli, Christopher J ^a   Green, Joanne Balmer ^a   Green, Michael H ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Compartmental model; Vitamin A sparing; WinSAAM

Indexed keywords

RETINOIC ACID; TRACER; TRITIUM;

ADRENAL GLAND; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCASS; CATABOLISM; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG EFFECT; DRUG LIVER LEVEL; EYE; ISOTOPE LABELING; KIDNEY; KINETICS; LUNG; MALE; NONHUMAN; PREDICTION; RAT; RETINOL DEFICIENCY; SIMULATION; SMALL INTESTINE; TESTIS; VITAMIN INTAKE; VITAMIN METABOLISM;

EID: 16244379859     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.4.746     Document Type: Article

References (32)

1. Varma, R. N. & Beaton, G. H. (1972) Quantitative aspects of the urinary and fecal excretion of radioactive metabolites of vitamin A in the rat. Can. J. Physiol. Pharmacol. 50: 1026-1037.
2. Hicks, V. A., Gunning, D. B. & Olson, J. A. (1984) Metabolism, plasma transport and biliary excretion of radioactive vitamin A and its metabolites as a function of liver reserves of vitamin A in the rat. J. Nutr. 114: 1327-1333.
3. Green, M. H. & Green, J. B. (1994) Vitamin A intake and status influence retinol balance, utilization and dynamics in rats. J. Nutr. 124: 2477-2485.
4. Kelley, S. K. & Green, M. H. (1998) Plasma retinol is a major determinant of vitamin A utilization in rats. J. Nutr. 128: 1767-1773.
5. Goodman, D. S. (1984) Vitamin A and retinoids in health and disease. N. Engl. J. Med. 310: 1023-1031.
6. Gudas, L. J., Sporn, M. B. & Roberts, A. B. (1994) Cellular biology and biochemistry of the retinoids. In: The Retinoids: Biology, Chemistry, and Medicine (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), 2nd ed., pp. 443-520, Raven Press, New York, NY.
7. Lamb, A. J., Apiwatanaporn, P. & Olson, J. A. (1974) Induction of rapid, synchronous vitamin A deficiency in the rat. J. Nutr. 104: 1140-1148.
8. Keilson, B., Underwood, B. A. & Loerch, J. D. (1979) Effects of retinoic acid on the mobilization of vitamin A from the liver in rats. J. Nutr. 109: 787-795.
9. Lewis, K. C. (1987) Multicompartmental Tracer Kinetic Analysis of Retinol Metabolism in Rats with Low Vitamin A Status. Doctoral thesis, The Pennsylvania State University, University Park, PA.
10. Lewis, K. C., Green, J. B. & Green, M. H. (1988) Effects of retinoic acid supplementation on retinol kinetics in rats with low vitamin A status. FASEB J. 2: A844 (abs.).
11. Lewis, K. C., Green, M. H., Green, J. B. & Zech, L. A. (1990) Retinol metabolism in rats with low vitamin A status: a compartmental model. J. Lipid Res. 31: 1535-1548.
12. Green, M. H., Green, J. B. & Lewis, K. C. (1992) Model-based compartmental analysis of retinol kinetics in organs of rats at different levels of vitamin A status. In: Retinoids: Progress in Research and Clinical Applications (Livrea, M. A. & Packer, L., eds.), pp. 185-204. Marcel Dekker, New York, NY.
13. Green, M. H., Green, J. B. & Lewis, K. C. (1987) Variation in retinol utilization rate with vitamin A status in the rat. J. Nutr. 117: 694-703.
14. Green, M. H. & Green, J. B. (1990) Experimental and kinetic methods for studying vitamin A dynamics in vivo. Meth. Enzymol. 190: 304-317.
15. Thompson, J. N., Erdody, P., Brien, R. & Murray, T. K. (1971) Fluorometric determination of vitamin A in human blood and liver. Biochem. Med. 5: 67-89.
16. Hara, A. & Radin, N. S. (1978) Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem. 90: 420-426.
17. Duncan, T. E., Green, J. B. & Green, M. H. (1993) Liver vitamin A levels in rats are predicted by a modified isotope dilution technique. J. Nutr. 123: 933-939.
18. Wastney, M. E., Patterson, B. H., Linares, O. A., Greif, P. C. & Boston, R. C. (1999) Investigating Biological Systems Using Modeling, pp. 95-138. Academic Press, San Diego, CA.
19. Wastney, M. E., Patterson, B. H., Linares, O. A., Greif, P. C. & Boston, R. C. (1999) Investigating Biological Systems Using Modeling, pp. 202-208. Academic Press, San Diego, CA.
20. Green, M. H. & Green, J. B. (1990) The application of compartmental analysis to research in nutrition. Annu. Rev. Nutr. 10: 41-61.
21. cells factor in the normal and splenectomized Sherman rat. Am. J. Physiol. 196: 188-192.
22. Underwood, B. A., Loerch, J. D. & Lewis, K. C. (1979) Effects of dietary vitamin A deficiency, retinoic acid and protein quantity and quality on serially obtained plasma and liver levels of vitamin A in rats. J. Nutr. 109: 796-806.
23. Blaner, W. S. & Olson, J. A. (1994) Retinol and retinoic acid metabolism. In: The Retinoids: Biology, Chemistry, and Medicine (Sporn, M. B., Roberts, A. B. & Goodman, D. S., eds.), 2nd ed., pp. 229-255. Raven Press, New York, NY.
24. Green, M. H., Uhl, L. & Green, J. B. (1985) A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores. J. Lipid Res. 26: 806-818.
25. Kurlandsky, S. B., Gamble, M. V., Ramakrishnan, R. & Blaner, W. S. (1995) Plasma delivery of retinoic acid to tissues in the rat. J. Biol. Chem. 270: 17850-17857.
26. Landaw, E. & DiStefano, J., III (1984) Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations. Am. J. Physiol. 246: R665-R677.
27. Allen, L. E., Green, M. H. & Green, J. B. (1994) Correspondence re: S. E. Dew et al., Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes. Cancer Res. 54: 3319-3320.
28. Nagy, N. E., Holven, K. B., Roos, N., Senoo, H., Kojima, N., Norum, K. R. & Blomhoff, R. (1997) Storage of vitamin A in extrahepatic stellate cells in normal rats. J. Lipid Res. 38: 645-658.
29. Zolfaghari, R., Wang, Y., Chen, Q., Sancher, A. & Ross, A. C. (2002) Cloning and molecular expression analysis of large and small lecithin:retinol acyltransferase mRNAs in the liver and other tissues of adult rats. Biochem. J. 368: 621-631.
30. Zolfaghari, R. & Ross, A. C. (2002) Lecithin:retinol acyltransferase expression is regulated by dietary vitamin A and exogenous retinoic acid in the lung of adult rats. J. Nutr. 132: 1160-1164.
31. Zolfaghari, R. & Ross, A. C. (2000) Lecithin:retinol acyltransferase from mouse and rat liver. cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid. J. Lipid Res. 41: 2024-2034.
32. Wang, Y., Zolfaghari, R. & Ross, A. C. (2002) Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch. Biochem. Biophys. 401: 235-243.