Molecular profiling of human chondrosarcomas for matrix production and cancer markers

International Journal of Cancer

Volumn 100, Issue 2, 2002, Pages 144-151

  Söderström, Mirva ^a   Böhling, Tom ^b   Ekfors, Tauno ^a   Nelimarkka, Lassi ^a   Aro, Hannu T ^a   Vuorio, Eero ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Chondrosarcoma; Collagen; Decorin; Microarray; SOX9

Indexed keywords

COLLAGEN; COLLAGEN TYPE 11; COLLAGEN TYPE 2; COMPLEMENTARY DNA; DECORIN; PROCOLLAGEN; REGULATOR PROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CHONDROSARCOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RIBONUCLEASE PROTECTION ASSAY; STEM CELL;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, NORTHERN; BONE NEOPLASMS; CELL DIFFERENTIATION; CHONDROSARCOMA; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HIGH MOBILITY GROUP PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0037054935     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10457     Document Type: Article

References (43)

1. Chondrosarcoma and mesenchymal chondrosarcoma
2. Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell)
3. Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms
4. Immunohistochemical localization of collagenous proteins in cartilaginous tumors: Characteristic distribution of type IX collagen
5. Chondrocyte differentiation
6. Sox9 is required for cartilage formation
7. The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones
8. Alternative splice form of type II procollagen mRNA (IIA) is predominant in skeletal precursors and non-cartilaginous tissues during early mouse development
9. Experience in the treatment of dedifferentiated chondrosarcoma
10. Prognostic factors in chondrosarcoma of bone: A clinicopathologic analysis with emphasis on histologic grading
11. Exploring the metabolic and genetic control of gene expression on a genomic scale
12. The transcriptional program in the response of human fibroblasts to serum
13. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species
14. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
15. Monoclonal antibodies to connective tissue macromolecules: Type II collagen
16. Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins
17. Synthesis of fibronectin, laminin, and several collagens by a liver-derived epithelial line
18. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
19. Human pro α 1(I) collagen: cDNA sequence for the C-propeptide domain
20. Determination of the single polyadenylation site of the human proα1(II) collagen gene
21. Co-expression of collagens II and XI and alternative splicing of exon 2 of collagen II in several developing human tissues
22. Construction of a human proα1(III) collagen cDNA clone and localization of type III collagen expression in human fetal tissues
23. SOX9 is a potent activator of the chondrocyte-specific enhancer of the proα1(II) collagen gene
24. Mapping of RNA with ribonuclease and radiolabelled RNA probes
25. Cysteine proteinases in chondrosarcomas
26. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcoma
27. Expression of cartilage extracellular matrix and potential regulatory genes in a new human chondrosarcoma cell line
28. Expression of mRNAs for collagens and other matrix components in dedifferentiating and redifferentiating human chondrocytes in culture
29. Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer
30. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
31. Accelerated upregulation of L-Sox5, Sox6 and Sox9 by BMP-2 gene transfer during murine fracture healing
32. The mouse collagen X gene: Complete nucleotide sequence, exon structure and expression pattern
33. Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus
34. Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in transgenic mouse model for osteoarthritis
35. Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene
36. Evidence for insufficient chondrocytic differentiation during repair of full-thickness defects of articular cartilage
37. Interaction of a 59-kDa connective tissue matrix protein with collagen I and collagen II
38. Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon
39. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis
40. Leucine-rich repeat glycoproteins of the extracellular matrix
41. Proteoglycans of the extracellular environment: Clues from the gene and protein side offer novel perspectives in molecular diversity and function
42. Measurement of total and local bone morphogenetic protein concentration in bone tumours
43. Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint