Sex-specific QTL effects on variation in paraoxonase 1 (PON1) activity in Mexican Americans

Genetic Epidemiology

Volumn 31, Issue 1, 2007, Pages 66-74

  Winnier, Deidre A ^a   Rainwater, David L ^a   Cole, Shelley A ^a   Williams, Jeff T ^a   Dyer, Thomas D ^a   Blangero, John ^a   MacCluer, Jean W ^a   Mahaney, Michael C ^a,b  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

Cardiovascular disease; Genotype by sex; Oxidative stress

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1;

ADULT; ANALYSIS OF VARIANCE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CHROMOSOME 12; CHROMOSOME 17; CHROMOSOME 19; CHROMOSOME 7Q; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; GENE INTERACTION; GENE LOCATION; GENETIC CORRELATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE BY SEX INTERACTION; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; MAXIMUM LIKELIHOOD METHOD; MICROSATELLITE MARKER; PEDIGREE; PROTEIN VARIANT; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

ADULT; ARYLDIALKYLPHOSPHATASE; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GENETIC SCREENING; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MEXICAN AMERICANS; MIDDLE AGED; QUANTITATIVE TRAIT LOCI; SEX FACTORS; TEXAS; VARIATION (GENETICS);

ANIMALIA;

EID: 33845930198     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20191     Document Type: Article

References (47)

1. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
2. Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE. 2004. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Hypertension 44:695-701.
3. binAli A, Zhang Q, Lim YK, Fang D, Retnam L, Lim SK. 2003. Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radic Biol Med 34:824-829.
4. Blangero J. 1993. Statistical genetic approaches to human adaptability. Hum Biol 65:941-966.
5. Blangero J. 1995. Genetic analysis of a common oligogenic trait with quantitative correlates: summary of GAW9 results. Genet Epidemiol 12:689-706.
6. Blatter-Garin MC, Kalix B, De Pree S, James RW. 2003. Aspirin use is associated with higher serum concentrations of the antioxidant enzyme, paraoxonase-1. Diabetologia 46:593-594.
7. Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE. 2000. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 10:453-460.
8. Carey G. 1988. Inference about genetic correlations. Behav Genet 18:329-338.
9. Chisolm GM, Steinberg D. 2000. The oxidative modification hypothesis of atherogenesis: an overview. Free Radical Biol Med 28:1815-1826.
10. Costa LG, Vitalone A, Cole TB, Furlong CE. 2005. Modulation of paraoxonase (PON1) activity. Biochem Pharmacol 69:541-550.
11. Deakin SP, James RW. 2004. Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1. Clin Sci (Lond) 107:435-447.
12. DiabetesPrimo-Parmo SL, Sorenson RC, Teiber J, La Du BN. 1996. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 33:498-507.
13. Eiberg H, Mohr J, Schmiegelow K, Nielsen LS, Williamson R. 1985. Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny. Clin Genet 28:265-271.
14. Ekstrem CT, Dalgaard P. 2003. Linkage analysis of quantitative trait loci in the presence of heterogeneity. Hum Hered 55:16-26.
15. Falconer DS. 1989. Introduction to Quantitative Genetics, 3rd edition. New York: Longman Scientific & Technical, John Wiley & Sons, Inc.
16. Feng Z, McCulloch CE. 1992. Statistical inference using maximum likelihood estimation and the generalized likelihood ratio when the true parameter is on the boundary of the parameter space. Stati Probab Lett 13:325-332.
17. Garin MC, James RW, Dussoix P, Blanche H, Passa P, Froguel P, Ruiz J. 1997. Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. J Clin Invest 99:62-66.
18. Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE. 1993. The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet 3:73-76.
19. Jarvik GP, Tsai NT, McKinstry LA, Wani R, Brophy VH, Richter RJ, Schellenberg GD, Heagerty PJ, Hatsukami TS, Furlong CE. 2002. Vitamin C and E intake is associated with increased paraoxonase activity. Arterioscler Thromb Vasc Biol 22:1329-1333.
20. Kleemola P, Freese R, Jauhiainen M, Pahlman R, Alfthan G, Mutanen M. 2002. Dietary determinants of serum paraoxonase activity in healthy humans. Atherosclerosis 160:425-432.
21. Lehmann EL. 1986. Testing Statistical Hypotheses, 2nd edition. New York: John Wiley and Sons.
22. Leviev I, James RW. 2000. Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations. Arterioscler Thromb Vasc Biol 20:516-521.
23. MacCluer JW, Stern MP, Almasy L, Atwood LA, Blangero J, Comuzzie AG, Dyke B, Haffner SM, Henkel RD, Hixson JE. 1999. Genetics of atherosclerosis risk factors in Mexican Americans. Nutr Rev 57:S59-S65.
24. Mackness MI, Durrington PN. 1995. HDL, its enzymes and its potential to influence lipid peroxidation. Atherosclerosis 115:243-253.
25. Mackness B, Mackness MI, Arrol S, Turkie W, Julier K, Abuasha B, Miller JE, Boulton AJ, Durrington PN. 1998. Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus. Atherosclerosis 139:341-349.
26. Mackness M, Boullier A, Hennuyer N, Mackness B, Hall M, Tailleux A, Duriez P, Delfly B, Durrington P, Fruchart JC. 2000. Paraoxonase activity is reduced by a pro-atherosclerotic diet in rabbits. Biochem Biophys Res Commun 269:232-236.
27. Mahaney MC, Blangero J, Rainwater DL, Mott GE, Comuzzie AG, MacCluer JW, VandeBerg JL. 1999. Pleiotropy and genotype by diet interaction in a baboon model for atherosclerosis: a multivariate quantitative genetic analysis of HDL subfractions in two dietary environments. Arterioscler Thromb Vasc Biol 19:1134-1141.
28. Mueller RF, Hornung S, Furlong CE, Anderson J, Giblett ER, Motulsky AG. 1983. Plasma paraoxonase polymorphism: a new enzyme assay, population, family, biochemical, and linkage studies. Am J Hum Genet 35:393-408.
29. Rainwater DL, Mahaney MC, Wang XL, Rogers J, Cox LA, VandeBerg JL. 2005. Determinants of variation in serum paraoxonase enzyme activity in baboons. J Lipid Res 46:1450-1456.
30. Rantala M, Silaste ML, Tuominen A, Kaikkonen J, Salonen JT, Alfthan G, Aro A, Kesaniemi YA. 2002. Dietary modifications and gene polymorphisms alter serum paraoxonase activity in healthy women. J Nutr 132:3012-3017.
31. Rich SS, Bowden DW, Haffner SM, Norris JM, Saad MF, Mitchell BD, Rotter JI, Langefeld CD, Hedrick CC, Wagenknecht LE. 2005. A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study. Diabetes 54:290-295.
32. Risinger FO, Quick E, Belknap JK. 2000. Quantitative trait loci for acute behavioral sensitivity to paraoxon. Neurotoxicol Teratol 22:667-674.
33. Self SG, Liang KL. 1987. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605-610.
34. Senti M, Tomas M, Vila J, Marrugat J, Elosua R, Sala J, Masia R. 2001. Relationship of age-related myocardial infarction risk and Gln/Arg 192 variants of the human paraoxonase1 gene: the REGICOR study. Atherosclerosis 156:443-449.
35. Seres I, Paragh G, Deschene E, Fulop T Jr, Khalil A. 2004. Study of factors influencing the decreased HDL associated PON1 activity with aging. Exp Gerontol 39:59-66.
36. Shih DM, Gu L, Hama S, Xia YR, Navab M, Fogelman AM, Lusis AJ. 1996. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. J Clin Invest 97:1630-1639.
37. Su SY, Chen JH, Huang JF, Wang XL, Zhao JG, Shen Y, Qiang BQ, Gu DF. 2005. Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. Chin Med J (Engl) 118:1167-1174.
38. Sutherland WH, Walker RJ, de Jong SA, van Rij AM, Phillips V, Walker HL. 1999. Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat. Arterioscler Thromb Vasc Biol 19:1340-1347.
39. Towne B, Blangero J, Siervogel RM. 1993. Genotype by sex interaction in measures of lipids, lipoproteins, and apolipoproteins. Genet Epidemiol 10:611-616.
40. Towne B, Siervogel RM, Blangero J. 1997. Effects of genotype-by-sex interaction on quantitative trait linkage analysis. Genet Epidemiol 14:1053-1058.
41. Towne B, Almasy L, Siervogel RM, Blangero J. 1999. Effects of genotype x sex interaction on linkage analysis of visual event-related evoked potentials. Genet Epidemiol 17 (Suppl. 1): S355-S360.
42. Uriel J. 1961. Characterization of cholinesterase and other carboxylic esterases after electrophoresis and immunoelectrophoresis on agar. I. Application to the study of esterases of normal human serum. Ann Inst Pasteur (Paris) 101:104-119.
43. Vincent-Viry M, Sass C, Bastien S, Aguillon D, Siest G, Visvikis S. 2003. PON1-192 phenotype and genotype assessments in 918 subjects of the Stanislas cohort study. Clin Chem Lab Med 41:535-540.
44. Wainwright BJ, Scambler PJ, Schmidtke J, Watson EA, Law HY, Farrall M, Cooke HJ, Eiberg H, Williamson R. 1985. Localization of cystic fibrosis locus to human chromosome 7cen-q22. Nature 318:384-385.
45. Weber WW. 1995. Influence of heredity on human sensitivity to environmental chemicals. Environ Mol Mutagen 25 (Suppl. 26):102-114.
46. Williams JT, North KE, Martin LJ, Comuzzie AG, Goring HH, Blangero J. 2001. Distribution of lod scores in oligogenic linkage analysis. Genet Epidemiol 21 (Suppl. 1):S805-S810.
47. Winnier DA, Rainwater DL, Cole SA, Dyer TD, Blangero J, MacCluer JW, Mahaney MC. 2006. Multiple QTLs influence variation in paraoxonase 1 (PON1) activity in Mexican Americans. Hum Biol 78:341-352.