Linkage analysis of quantitative trait loci in the presence of heterogeneity

Human Heredity

Volumn 55, Issue 1, 2003, Pages 16-26

  Ekstrøm, Claus Thorn ^a,b   Dalgaard, Peter ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

EM algorithm; Gaussian mixture; Heterogeneity; Linkage; Population admixture; Quantitative trait loci (QTL); Variance components

Indexed keywords

ALLELE; ARTICLE; GENETIC HETEROGENEITY; LINKAGE ANALYSIS; MATHEMATICAL MODEL; MAXIMUM LIKELIHOOD METHOD; METHODOLOGY; PEDIGREE; QUANTITATIVE TRAIT LOCUS;

CHROMOSOME MAPPING; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; GENETIC HETEROGENEITY; HUMANS; MATHEMATICAL COMPUTING; MODELS, GENETIC; PEDIGREE; PENETRANCE; PHENOTYPE; QUANTITATIVE TRAIT LOCI; VARIATION (GENETICS);

EID: 0042674201     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071806     Document Type: Article

References (24)

1. Allison DB, Fernandez JR, Heo M, Zhu S, Etzel C, Beasley TM, Amos CI: Bias in estimates of quantitative-trait-locus effect in genome scans: Demonstration of the phenomenon and a method-of-moments procedure for reducing bias. Am J Hum Genet 2002;70:575-585.
2. Allison DB, Neale MC, Zannolli R, Schork NJ, Amos CI, Blangero J: Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet 1999;65:531-544.
3. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198-1211.
4. Chiano MN, Yates JRW: Linkage detection under heterogeneity and the mixture problem. Ann Hum Genet 1995;59:83-95.
5. Faraway JJ: Distribution of the admixture test for the detection of linkage under heterogeneity. Genet Epidemiol 1993;10:75-83.
6. Goldgar DE: Multipoint analysis of human quantitative genetic variation. Am J Hum Genet 1990;47:957-967.
7. Goldin LR, Gershon ES: Power of the affected-sib-pair method for heterogeneous disorders. Genet Epidemiol 1988;5:35-42.
8. Goldstein D: A combined test of linkage heterogeneity. Am J Hum Genet 1994;55:841-848.
9. G̈ring HHH, Terwilliger JD, Blangero J: Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 2001;69:1357-1369.
10. Hopper JL, Mathews JD: Extensions to multivariate normal models for pedigree analysis. Ann Hum Genet 1982;46:373-383.
11. Lange K, Westlake J, Spence MA: Extensions to pedigree analysis III. Variance components by the scoring method. Ann Hum Genet 1976;39:485-491.
12. Lemdani M, Pons O: Tests for genetic linkage and homogeneity. Biometrics 1995;51:1033-1041.
13. Liang KY, Rathouz PJ: Hypothesis testing under mixture models: Application to genetic linkage analysis. Biometrics 1999;55:65-74.
14. McLachlan GJ, Peel D: Finite Mixture Models. New York, Wiley, 2000.
15. Mitchell BD, Ghosh S, Schneider JL, Birznieks G, Blangero J: Power of variance component linkage analysis to detect epistasis. Genet Epidemiol 1997;14:1017-1022.
16. Ott J: Analysis of Human Genetic Linkage. Baltimore, Johns Hopkins University Press, 1991.
17. Self SG, Liang KY: Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. JASA 1987;82:605-610.
18. Sham P: Statistics in Human Genetics. London, Arnold, 1998.
19. Shoukri MM, Lathrop GM: Statistical testing of genetic linkage under heterogeneity. Biometrics 1993;49:151-161.
20. Smith CAB: Testing for heterogeneity of recombination values in human genetics. Annals of Human Genetics 1963;84:175-182.
21. Titterington DM, Smith AFM, Makov UE: Statistical Analysis of Finite Mixture Distributions. New York, Wiley, 1985.
22. Vieland VJ, Logue M: HOLDs, trait models, and ascertainment: Implications of admixture for parameter estimation and linkage detection. Hum Hered 2002;53:23-35.
23. Watanabe RM, Ghosh S, Birznieks G, Duren WL, Mitchell BD: Application of an ordered subset analysis approach to the genetics of alcoholism. Genet Epidemiol 1999;17(suppl 1): S385-S390.
24. Whittemore AS, Halpern J: Problems in the definition, interpretation, and evaluation of genetic heterogeneity. Am J Hum Genet 2001;68:457-465.