Relationship of age-related myocardial infarction risk and Gln/Arg 192 variants of the human paraoxonase1 gene: The REGICOR study

Atherosclerosis

Volumn 156, Issue 2, 2001, Pages 443-449

  Sentí, Mariano ^a   Tomás, Marta ^a   Vila, Juan ^a   Marrugat, Jaume ^a   Elosua, Roberto ^a   Sala, Joan ^b   Masiá, Rafel ^b  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Aging; Myocardial infarction; Paraoxonase; Paraoxonase genotypes

Indexed keywords

ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; GENE DOSAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AGE DISTRIBUTION; ANALYSIS OF VARIANCE; ARYLDIALKYLPHOSPHATASE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; COHORT STUDIES; ESTERASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; INCIDENCE; LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; PREGNANCY; REFERENCE VALUES; RISK ASSESSMENT; RISK FACTORS; SEX DISTRIBUTION;

EID: 0034995225     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(00)00680-8     Document Type: Article

References (34)

1. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein
2. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
3. Paraoxonase: Biochemistry, genetics and relationship to plasma lipoproteins
4. Gln-Arg 192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes
5. Paraoxonase gene polymorphism in Japanese subjects with coronary heart disease
6. A 192Arg variant of the human paraoxonase (HUMPONA) gene polymorphism is associated with an increased risk for coronary artery disease in the Japanese
7. Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases
8. A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease
9. The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary heart disease in Finns
10. The paraoxonase Gln-Arg 192 polymorphism in subjects with ischaemic heart disease
11. The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM study
12. The Gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in Italian patients
13. Risk of myocardial infarction associated with Gln/Arg 192 polymorphism in human paraoxonase gene and diabetes mellitus
14. The role of oxidized lipoprotein in atherogenesis
15. Genetics and the pathobiology of ageing
16. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions: A possible peroxidative role for paraoxonase
17. Atherosclerosis and the vascular biology of aging
18. High prevalence of cardiovascular risk factors in Gerona, Spain: A province with low myocardial infarction incidence
19. Acute myocardial infarction case fatality, incidence and mortality rates in a population registry in the province of Girona, Spain, 1990-1992
20. A simple salting-out procedure for extracting DNA from human nucleated cells
21. The molecular basis of the human serum paraoxonase activity polymorphism
22. Differential effects of smoking on myocardial infarction risk according the Gln/Arg variants of the human paraoxonase gene
23. Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia
24. Distribution of paraoxon hydrolytic activity in the serum of patients after myocardial infarction
25. Durrington. Serum paraoxonase after myocardial infarction
26. Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q → R genetic polymorphism
27. Serum paraoxonase activity in familial hypercholesterolemia and insulin-dependent diabetes mellitus
28. Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypercholesterolemic patients
29. Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus
30. Increase in hydroxy fatty acids in human low density lipoproteins with age
31. Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
32. Oxidative status of lipoproteins in coronary disease patients
33. Minimum sample size to detect gene-environment interaction in case-control designs
34. LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: Role of prooxidants versus antioxidants