Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis

Biochemistry

Volumn 45, Issue 51, 2006, Pages 15301-15309

  Lee, Duck Yeon ^a   Park, Sung Jun ^a   Jeong, Woojin ^b   Sung, Ho Jin ^b   Oho, Taena ^b   Wu, Xiongwu ^a   Rhee, Sue Goo ^a,b   Graschus, James M ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; CYSTEINESULFINIC ACID; KINASE FAMILY PROTEINS; SULFIREDOXIN;

CATALYSIS; CHEMICAL BONDS; HYDROLYSIS; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PEROXIDES; X RAY ANALYSIS;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ALANINE; ASPARAGINE; ASPARTIC ACID; CYSTEINE SULFINIC ACID; MUTANT PROTEIN; PEROXIDASE; PEROXIDE; PEROXIREDOXIN; PHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN PRX I; SULFIREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROLYSIS; MOLECULAR MODEL; MUTAGENESIS; MUTATION; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REDUCTION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ASPARAGINE; ASPARTIC ACID; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; OXIDOREDUCTASES; PEROXIREDOXINS; PROTEIN STRUCTURE, TERTIARY;

EID: 33845930075     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061824h     Document Type: Article

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