CD8+ T cells armed with retrovirally transduced IFN-γ

Journal of Molecular Medicine

Volumn 85, Issue 1, 2007, Pages 63-73

  Becker, Christian ^a   Lienenklaus, Stefan ^a   Jablonska, Jadwiga ^a   Bauer, Heike ^a   Weiss, Siegfried ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

CD8+ T cell; IFN ; Retroviral transduction

Indexed keywords

COMPLEMENTARY DNA; GAMMA INTERFERON; RETROVIRUS VECTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOLYSIS; GENETIC TRANSCRIPTION; IMMUNOPATHOLOGY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RETROVIRUS; RNA TRANSLATION; T LYMPHOCYTE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION; GENETIC VECTORS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 33845909283     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-006-0107-8     Document Type: Article

References (32)

1. Guidotti LG, Borrow P, Brown A, McClary H, Koch R, Chisari FV (1999) Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J Exp Med 189:1555-1564
2. Guidotti LG, Rochford R, Chung J, Shapiro M, Purcell R, Chisari FV (1999) Viral clearance without destruction of infected cells during acute HBV infection. Science 284:825-829
3. Bartholdy C, Christensen JP, Wodarz D, Thomsen AR (2000) Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus. J Virol 74:10304-10311
4. Barth RJ Jr, Mule JJ, Spiess PJ, Rosenberg SA (1991) Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes. J Exp Med 173:647-658
5. Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD (1998) Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A 95:7556-7561
6. Qin Z, Schwartzkopff J, Pradera F, Kammertoens T, Seliger B, Pircher H, Blankenstein T (2003) A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8+ T cells. Cancer Res 63:4095-4100
7. Schwartzentruber DJ, Topalian SL, Mancini M, Rosenberg SA (1991) Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation. J Immunol 146:3674-3681
8. Becker C, Pohla H, Frankenberger B, Schuler T, Assenmacher M, Schendel DJ, Blankenstein T (2001) Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay. Nat Med 7:1159-1162
9. Nakajima C, Uekusa Y, Iwasaki M, Yamaguchi N, Mukai T, Gao P, Tomura M, Ono S, Tsujimura T, Fujiwara H, Hamaoka T (2001) A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice. Cancer Res 61:3399-3405
10. Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease LR, Rodriguez M, Guo Y, Chen L (2002) Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy. Cancer Res 62:4413-4418
11. Von Herrath MG, Coon B, Oldstone MB (1997) Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection. Virology 229:349-359
12. Morgan DJ, Liblau R, Scott B, Fleck S, McDevitt HO, Sarvetnick N, Lo D, Sherman LA (1996) CD8(+) T cell-mediated spontaneous diabetes in neonatal mice. J Immunol 157:978-983
13. Matzinger P (1991) The JAM test. A simple assay for DNA fragmentation and cell death. J Immunol Methods 145:185-192
14. Staudt LM, Gerhard W (1983) Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice. J Exp Med 157:687-704
15. Young HA (1996) Regulation of interferon-gamma gene expression. J Interferon Cytokine Res 16:563-568
16. Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R (2002) Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 108:221-232
17. Elser B, Lohoff M, Kock S, Giaisi M, Kirchhoff S, Krammer PH, Li-Weber M (2002) IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity 17:703-712
18. Dobrzanski MJ, Reome JB, Dutton RW (1999) Therapeutic effects of tumor-reactive type 1 and type 2 CD8+ T cell subpopulations in established pulmonary metastases. J Immunol 162:6671-6680
19. Kemp RA, Ronchese F (2001) Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity. J Immunol 167:6497-6502
20. Yang J, Zhu H, Murphy TL, Ouyang W, Murphy KM (2001) IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production. Nat Immunol 2:157-194
21. + T cell homeostasis by perforin and interferon-gamma. Science 290:1354-1358
22. Tau GZ, Cowan SN, Weisburg J, Braunstein NS, Rothman PB (2001) Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells. J Immunol 167:5574-5582
23. Bestor TH (2000) Gene silencing as a threat to the success of gene therapy. J Clin Invest 105:409-411
24. Cooper IJ, Topp MS, Pinzon C, Plavec I, Jensen MC, Riddell SR, Greenberg PD (2004) Enhanced transgene expression in quiescent and activated human CD8+ T cells. Hum Gene Ther 7:648-658
25. Slifka MK, Rodriguez F, Whitton JL (1999) Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells. Nature 401:76-79
26. Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM (2006) Activation of the integrated stress response during T helper cell differentiation. Nat Immunol 7:644-651
27. Arenberg DA, Kunkel SL, Polverini PJ, Morris SB, Burdick MD, Glass MC, Taub DT, Iannettoni MD, Whyte RI, Strieter RM (1996) Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases. J Exp Med 184:981-992
28. Krasagakis K, Garbe C, Zouboulis CC, Orfanos CE (1995) Growth control of melanoma cells and melanocytes by cytokines. Recent Results Cancer Res 139:169-182
29. Bohm W, Thoma S, Leithauser F, Moller P, Schirmbeck R, Reimann J (1998) T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas. J Immunol 161:897-908
30. Nishihara K, Miyatake S, Sakata T, Yamashita J, Kikuchi H, Kawade Y, Zu Y, Namba Y, Hanaoka M, Watanabe Y (1988) Augmentation of tumor targeting in a line of glioma-specific mouse cytotoxic T-lymphocytes by retroviral expression of mouse gamma-interferon complementary DNA. Cancer Res 48:4730-4735
31. Miyatake S, Nishihara K, Kikuchi H, Yamashita J, Namba Y, Hanaoka M, Watanabe Y (1990) Efficient tumor suppression by glioma-specific murine cytotoxic T lymphocytes transfected with interferon-gamma gene. J Natl Cancer Inst 82:217-220
32. Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR (2003) Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med 9:231-235