Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells

Toxicology and Applied Pharmacology

Volumn 218, Issue 1, 2007, Pages 30-36

  Huang, Tom Hsun Wei ^a   Tran, Van Hoan ^a   Roufogalis, Basil D ^a   Li, Yuhao ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Gynostemma pentaphyllum; Gypenoside; Peroxisome proliferator activated receptor; Tissue factor

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; CHROMOGENIC SUBSTRATE; GLYCOSIDE; GYNOSTEMMA PENTAPHYLLUM EXTRACT; GYPENOSIDE; GYPENOSIDE XLIX; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; PLANT EXTRACT; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHINESE MEDICINE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; GYNOSTEMMA PENTAPHYLLUM; HUMAN; HUMAN CELL; INFLAMMATION; INHIBITION KINETICS; MEDICINAL PLANT; METASTASIS; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; TUMOR GROWTH;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARDIOVASCULAR AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GYNOSTEMMA; HUMANS; INDOLES; LIPOPOLYSACCHARIDES; MONOCYTES; NF-KAPPA B; PEROXISOME PROLIFERATORS; PPAR ALPHA; PROMOTER REGIONS (GENETICS); PYRIMIDINES; PYRROLIDINES; RNA, MESSENGER; SAPONINS; THIOCARBAMATES; THROMBOPLASTIN; TRANSCRIPTION, GENETIC; TRANSFECTION;

GYNOSTEMMA PENTAPHYLLUM;

EID: 33845908183     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.10.013     Document Type: Article

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