2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells

Cancer Research

Volumn 64, Issue 23, 2004, Pages 8512-8516

  Agata, Naoki ^a   Nogi, Hiroko ^b   Milhollen, Michael ^a   Kharbanda, Surender ^a   Kufe, Donald ^b  

^a ILEX Products Inc   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (8 HYDROXY 6 METHOXY 1 OXO 1H 2 BENZOPYRAN 3 YL)PROPIONIC ACID; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; DEXAMETHASONE; ISOCOUMARIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LETHALITY; MITOCHONDRION; MULTIPLE MYELOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASE 9; CASPASES; CELL LINE, TUMOR; COUMARINS; CYTOCHROMES C; DEXAMETHASONE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOCOUMARINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MULTIPLE MYELOMA; REACTIVE OXYGEN SPECIES;

EID: 9244256818     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2626     Document Type: Article

References (6)

1. Salloum R, Jaskowiak N, Mauceri H, et al. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res 2000;60:6958-63.
2. Yin L, Ohno T, Weichselbaum R, Kharbanda S, Kufe D. The novel isocoumarin NM-3 induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther 2001;1:43-8.
3. Reimer C, Agata N, Tammam J, et al. Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res 2002;62:789-95.
4. Bonate PL, Eder JP, Soulie P, et al. Pharmacokinetics of a new antiangiogenic isocoumarin derivative, NM-3, in two oral once a day-dose schedules with escalating doses. Proc Am Soc Clin Oncol 2003;22:134 (abstract 537).
5. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33-42.
6. Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000;102:43-53.