Can 5-azacytidine convert the adult stem cells into cardiomyocytes? A brief overview

Archives of Physiology and Biochemistry

Volumn 112, Issue 4-5, 2006, Pages 260-264

  Burlacu, Alexandrina ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

Author keywords

5 azacytidine; Bone marrow; Cardiomyocytes; Mesenchymal stem cells

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALPHA ACTIN; AZACITIDINE; DESMIN; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.5; TROPONIN T; VASCULOTROPIN RECEPTOR 2;

CELL DIFFERENTIATION; CELL MATURATION; CELL POPULATION; CELL STRUCTURE; DEMETHYLATION; DNA METHYLATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEART INJURY; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; HUMAN; IN VITRO STUDY; MESENCHYME CELL; MICROENVIRONMENT; MUSCLE FIBER CONTRACTION; NONHUMAN; PROTEIN EXPRESSION; REVIEW; STEM CELL; STEM CELL TRANSPLANTATION;

ADULT STEM CELLS; AZACITIDINE; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION; HEART INJURIES; HUMANS; MYOBLASTS, CARDIAC; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; VENTRICULAR REMODELING;

EID: 33845876332     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.1080/13813450601094631     Document Type: Review

References (34)

1. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez-Buylla A. 2003. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425:968-73.
2. Antequera F, Boyes J, Bird A. 1990. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62:503-14.
3. Baksh D, Song L, Tuan RS. 2004. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 3:301-16.
4. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. 1998. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72:141-6.
5. Bel A, Messas E, Agbulut O, Richard P, Samuel J-L, Bruneval P, Hagège AA, Menasché P. 2003. Transplantation of autologous fresh bone marrow into infarcted myocardium: a word of caution. Circulation 108:II247-52.
6. Bianco P, Riminucci M, Gronthos S, Gehron Robeyc P. 2001. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180-92.
7. Bittira B, Kuang J-Q, Al-Khaldi A, Shum-Tim D, Chiu RC-J. 2002. In vitro preprograming of marrow stromal cells for myocardial regeneration. Ann Thorac Surg 74:1154-60.
8. Cerny J, Quesenberry PJ. 2004. Chromatin Remodeling and Stem Cell Theory of Relativity. J Cell Physiol 201:1-16.
9. Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP. 2004. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 94:92-5.
10. Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlstrom H, Lendahl U, Frisen J. 2000. Generalized potential of adult neural stem cells. Science 288:1660-3.
11. Colter DC, Sekiya I, Prockop DJ. 2001. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. PNAS 98:7841-5.
12. Fernandez-Aviles F, San Roman JA, Garcia-Frade J, Fernandez ME, Penarrubia MJ, de la Fuente L, Gomez-Bueno M, Cantalapiedra A, Fernandez J, Gutierrez O, Sanchez PL, Hernandez C, Sanz R, Garcia-Sancho J, Sanchez A. 2004. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res 95:742-8.
13. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F. 1998. Muscle regeneration by bone marrow- derived myogenic progenitors. Science 279:1528-30.
14. Friedenstein AJ, Kailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. 1974. Stromal cells responsible for transferring the microenvironment of the hematopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17:331-40.
15. Jiang Y, Jahagirdar BN, Rheinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. 2002. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-9.
16. Koc O, Lazarus H. 2001. Mesenchymal stem cells: heading into the clinic. Bone marrow transplant 27:235-9.
17. Konieczny SF, Emerson CP. 1984. 5-azacytidine induction of stable mesodermal stem cell lineages from 10T1/2 cells: evidence for regulatory genes controlling determination. Cell 38:791-800.
18. Kudo M, Wang Y, Wani A, Xu M, Ayub A, Ashraf M. 2003. Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol 35:1113-19.
19. Kuethe F, Richartz BM, Sayer HG, Kasper C, Werner GS, Hoffken K, Figulla HR. 2004. Lack of regeneration of myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans with large anterior myocardial infarctions. Int J Cardiol 97:123-7.
20. Larsen F, Gundersen G, Lopez R, Prydz H. 1992. CpG islands as gene markers in the human genome. Genomics 13:1095-107.
21. Liu Y, Song J, Liu W, Wan Y, Chen X, Hu C. 2003. Growth and differentiation of rat bone marrow stromal cells: does 5-azacytidine trigger their cardiomyogenic differentiation? Cardiovasc Res 58:460-8.
22. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, Hata J-J, Umezawa A, Ogawa S. 1999. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 103:697-705.
23. Orlic D, Fischer R, Nishikawa S, Nienhuis AW, Bodine DM. 1993. Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood 82:762-70.
24. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. 2001. Bone marrow cells regenerate infarcted myocardium. Nature 410:701-5.
25. Quesenberry PJ, Colvin GA, Lambert JF. 2002. The Chiaroscuro stem cell: A unified stem cell theory. Blood 100: 4266-71.
26. Rosenstrauch D, Poglajen G, Zidar N, Gregoric ID. 2005. Stem cell therapy for ischemic heart failure. Tex Heart Inst J 32:339-47.
27. Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RV, Oliveira EM, He R, Geng YJ, Willerson JT, Perin EC. 2005. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111:150-6.
28. Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz DM, Nakano Y, Meyer EM, Morel L, Petersen BE, Scott EW. 2002. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416:542-5.
29. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. 2002. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105:93-8.
30. Tomita S, Li R-K, Weisel R, Mickle DA, Kim EJ, Sakai T, Jia ZQ. 1999. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100:II247-56.
31. Wakitani S, Saito T, Caplan AI. 1995. Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve 18:1417-26.
32. Wang J, Shum-Tim D, Galipeau J, Chedrawy E, Eliopoulos N, Chiu R. 2000. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J Thorac Cardiovasc Surg 120:999-1006.
33. Xu W, Zhang X, Qian H, Zhu W, Sun X, Hu J, Zhou H, Chen Y. 2004. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med 229:623-31.
34. Zhang FB, Li L, Fang B, Zhu DL, Yang HT, Gao PJ. 2005. Passage-restricted differentiation potential of mesenchymal stem cells into cardiomyocyte-like cells. Biochem Biophys Res Commun 336:784-92.