Genital and subjective measurement of the time course effects of an acute dose of testosterone vs. placebo in postmenopausal women

Journal of Sexual Medicine

Volumn 4, Issue 1, 2007, Pages 209-217

  Heard Davison, Amy ^a   Heiman, Julia R ^b   Kuffel, Stephanie ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Sexual response; Testosterone; Vaginal pulse amplitude

Indexed keywords

METHYLTESTOSTERONE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SELF REPORT; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; VAGINA; VIDEORECORDING; WILCOXON SIGNED RANKS TEST;

EID: 33845765256     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2006.00406.x     Document Type: Article

References (52)

1. Bancroft J. Androgens and sexual function in men and women. In: Bremner WJ, Bagatell C, eds. Androgens in health and disease. Totowa, NJ: Humana Press; 2003: 259-90.
2. Davis SR. The role of androgens and the menopause in the female sexual response. Int J Imp Res 1998;10:S82-3.
3. van Lunsen RHW, Laan E. Sex, hormones and the brain. Eur J Contracept Reprod Health Care 1997;2:247-51.
4. Sarrel PM. Effects of hormone replacement therapy on sexual psychophysiology and behavior in postmenopause. J Womens Health 2000;9:S25-32.
5. Sherwin B. Randomized clinical trials of combined estrogen-androgen preparations: Effects on sexual functioning. Fertil Steril 2002;77:S49-54.
6. Bancroft J, Sanders D, Davidson D, Warner P. Mood, sexuality, hormones, and the menstrual cycle. III. Sexuality and the role of androgens. Psychosom Med 1983;45:509-16.
7. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987;49:397-409.
8. Nappi R, Salonia A, Traish AM, Van Lunsen RH, Vardi Y, Kodiglu A, Goldstein I. Clinical biologic pathophysiologies of women's sexual dysfunction. J Sex Med 2005;2:4-25.
9. Bachmann G, Bancroft J, Braunstein G, Burger H, Davis S, Dennerstein L, Goldstein I, Guay A, Leiblum S, Lobo R, Notelovitz M, Rosen R, Sarrel P, Sherwin B, Simon J, Simpson E, Shifren J, Spark R, Traish A. Female androgen insufficiency: The Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002;77:660-5.
10. Graziottin A, Leiblum S. Biological and psychosocial pathophysiology of female sexual dysfunction during the menopausal transition. J Sex Med 2005;2:133-45.
11. Bancroft J, Sherwin BB, Alexander GM, Davidson DW, Walker A. Oral contraceptives, androgens, and the sexuality of young women. II. The role of androgens. Arch Sex Behav 1991;20:121-35.
12. Van Goozen SHM, Wiegant VM, Endert E, Helmond FA, Van de Poll NE. Psychoendocrinological assessment of the menstrual cycle: The relationship between hormones, sexuality, and mood. Arch Sex Behav 1997;26:359-82.
13. Alexander GM, Sherwin BB, Bancroft J, Davidson D. Testosterone and sexual behavior in oral contraceptive users and nonusers: A prospective study. Horm Behav 1990;24:388-402.
14. Alexander GM, Sherwin BB. Sex steroids, sexual behavior, and selective attention for erotic stimuli in women using oral contraceptives. Psychoneuroendocrinology 1993;18:91-102.
15. Dennerstein L, Koochaki P, Barton I, Graziottin A. Hypoactive sexual desire disorder in menopausal women: A survey of Western European women. J Sex Med 2006;3:212-22.
16. Aziz A, Brannstrom M, Bergquist C, Silverstolpe G. Perimenopausal androgen decline after oophorectomy does not influence sexuality or psychological well-being. Fertil Steril 2005;83:1021-8.
17. Davis S, Davison S, Donath S, Bell RJ. Circulating androgen levels and self-reported sexual function in women. JAMA 2005;294:91-6.
18. Gerber JR, Johnson JV, Bunn JY, O'Brien SL. A longitudinal study of the effects of free testosterone and other psychosocial variables on sexual function during the natural traverse of menopause. Fertil Steril 2005;83:643-8.
19. Guthrie JR, Dennerstein L, Taffe JR, Lehert P, Burger HG. The menopausal transition: A 9-year prospective population-based study. The Melbourne Women's Midlife Health Project. Climacteric 2004;7:375-89.
20. Santoro N, Torrens J, Crawford S, Allsworth JE, Finkestein JS, Gold EB, Korenman S, Lasley WL, Luborsky JL, McConnell D, Sowers MF, Weiss G. Correlates of circulating androgens in mid-life women: The study of women's health across the nation. J Clin Endocrinol Metabol 2005;90:4836-45.
21. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. J Reprod Med 1998;43:847-56.
22. Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-36.
23. Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: Effects on sexuality and well-being. Climacteric 2002;5:357-65.
24. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impared sexual function after oopharectomy. N Engl J Med 2000;343:682-8.
25. Sherwin BB, Gelfand MM. Individual differences in mood with menopausal replacement therapy: Possible role of sex hormone-binding globulin. J Psychosom Obstet Gynaecol 1987;6:121-31.
26. Sherwin BB. Changes in sexual behavior as a funciton of plasma sex steroid levels in post-menopausal women. Maturitas 1985;7:225-33.
27. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: A prospective, cross-over study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-51.
28. Alexander JL, Kotz K, Dennerstein L, Kutner SJ, Wallen K, Notelovitz M. The effects of postmenopausal hormone therapies on female sexual functioning: A review of double-blind randomized controlled trials. Menopause 2004;11:749-65.
29. Lobo RA, Rosen RC, Yan H, Block B, Van Der Hoop RG. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003;79:1341-52.
30. Davis S, Guay A, Shifren J, Mazer NA. Endocrine aspects of female sexual dysfunction. J Sex Med 2004;1:82-6.
31. Segraves R, Woodard T. Female hypoactive sexual desire disorder: History and current status. J Sex Med 2006;3:408-18.
32. Myers LS, Dixen J, Morrissette D, Carmichael M, Davidson JM. Effects of estrogen, androgen, and progestin on sexual psychophysiology and behavior in postmenopausal women. J Clin Endocrinol Metabol 1990;70:1124-31.
33. Sarrel PM, Wiita B. Vasodilator effects of estrogen are not diminished by androgen in postmenopausal women. Fertil Steril 1997;68:1125-7.
34. Bellerose SB, Binik YM. Body image and sexuality in oopharectomized women. Arch Sex Behav 1993;22:435-59.
35. Tuiten A, Honk JV, Kopeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 2000;57:149-53.
36. Tuiten A, van Honk J, Verbaten R, Laan E, Everaerd W. Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Arch Gen Psychiatry 2002;59:465.
37. Apperloo M, Midden M, van der Stege J, Wouda J, Hoek A, Weijmar Schultz W. Vaginal application of testosterone: A study on pharmacokinetics and the sexual response in healthy volunteers. J Sex Med 2006;3:408-18.
38. Basson R. Sexuality and sexual disorders. Clin Updat Womens Health Care 2003;11:1-94.
39. Basson R, Brotto LA. Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: A randomised controlled trial. BJOG 2003;110:1014-24.
40. Everaerd W, Laan E, Both S, Van der Velde J. Female sexuality. In: Szuchman LT, Muscarella R, eds. Psychological perspectives of human sexuality. New York: Wiley; 2000: 111-23.
41. Hackbert L, Heiman JR. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health 2002;11:147-54.
42. Heiman JR, Rowland DL. Affective and physiological sexual response patterns: The effects of instructions on sexually functional and dysfunctional men. J Psychosom Res 1983;27:105-16.
43. Heiman JR. Issues in the use of psychophysiology to assess female sexual dysfunction. J Sex Marital Ther 1977;3:197-204.
44. Heiman JR. A psychophysiological exploration of sexual arousal patterns in females and males. Psychophysiology 1977;14:266-74.
45. Meston CM, Heiman JR. Ephedrine-activated physiological sexual arousal in women. Arch Gen Psychiatry 1998;55:652-6.
46. Barrett-Connor E, Young R, Notelovitz M, Sullivan J, Wiita B, Yang HM, Nolan J. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999;44:1012-20.
47. Penotti M, Sironi L, Cannata L, Vigano P, Casini A, Gabrielli L, Vignali M. Effects of androgen supplementation of hormone replacement therapy on the vascular reactivity of cerebral arteries. Fertil Steril 2001;76:235-40.
48. Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry 2000;57:1012-30.
49. Kaplan HS, Owett T. The female androgen deficiency syndrome. J Sex Marital Ther 1993;19:3-24.
50. Davis SR. The therapeutic use of androgens in women. J Steroid Biochem Mol Biol 1999;69:177-84.
51. Goldstein I, Alexander JL. Practical aspects in the management of vaginal atrophy and sexual dysfunction in perimenopausal and postmenopausal women. J Sex Med 2005;2:154-65.
52. Hayes R, Dennerstein L. The impact of aging on sexual function and sexual dysfunction in women: A review of population-based studies. J Sex Med 2005;2:217-330.