Vaginal application of testosterone: A study on pharmacokinetics and the sexual response in healthy volunteers

Journal of Sexual Medicine

Volumn 3, Issue 3, 2006, Pages 541-549

  Apperloo, Mirjam ^a   Midden, Marlies ^a   van der Stege, Jolande ^a   Wouda, Jan ^a   Hoek, Annemieke ^a   Weijmar Schultz, Willibrord ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Pharmacokinetics; Sexual response; Testosterone propionate; Vaginal application; Vaginal plethysmography

Indexed keywords

ESTRADIOL; PLACEBO; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EROTISM; ESTRADIOL BLOOD LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PLETHYSMOGRAPHY; PREMENOPAUSE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SEXUAL AROUSAL; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SINGLE DRUG DOSE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL; VISUAL ANALOG SCALE; VOLUNTEER;

EID: 33646012977     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2006.00212.x     Document Type: Article

References (26)

1. Bachmann G, Bancroft J, Braunstein G, Burger H, Davis S, Dennerstein L, Goldstein I, Guay A, Leiblum S, Lobo G, Notelovitz M, Rosen R, Sarrel P, Sherwin B, Simon J, Simpson E, Shifren J, Spark R, Traish A. Female androgen insufficiency: The Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002; 77: 660-5.
2. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: A prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985; 47: 339-51.
3. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med 1987; 49: 397-409.
4. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343: 682-8.
5. Lobo RA, Rosen RC, Yang HM, Block B, van der Hoop RG. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003; 79: 1341-52.
6. Goldstat R, Briganti E, Tran J, Wolfe R, Davis SR. Transdermal testosterone therapy improves well-being, mood and sexual function in premenopausal women. Menopause 2003; 10: 390-8.
7. Apperloo MJA, van der Stege JG, Hoek A, Weijmar Schultz WCM. In the mood for sex: The value of androgens. J Sex Marital Ther 2003; 29: 87-102.
8. Karama S, Lecours AR, Leroux JM, Bourgouin P, Beaudoin G, Joubert S, Beauregard M. Areas of brain activation in males and females during viewing of erotic film excerpts. Human Brain Mapping 2002; 16: 1-13.
9. Bixo M, Bäckström T, Winblad B, Andersson A. Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 1995; 55: 297-303.
10. Rommerts FFG. Testosterone: An overview of biosynthesis, transport, metabolism and nongenomic actions. In: Nieschlag, E, Behre, HM, eds. Testosterone. Berlin, Heidelberg: Springer-Verlag; 1998: 1-32.
11. Basson R. A model of women's sexual arousal. J Sex Marital Ther 2002; 28: 1-10.
12. Levin RJ. VIP, vagina, clitoral and periurethral glans - An update on human female genital arousal. Exp Clin Endocrinol 1991; 98: 61-9.
13. Traish AM, Kim N, Min K, Munarriz R, Goldstein I. Role of androgens in female genital sexual arousal: Receptor expression, structure, and function. Fertil Steril 2002; 77: S1-8.
14. Munarriz R, Wong Kim S, Kim NN, Traish A, Goldstein I. A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model. J Urol 2003; 170: S40-S45.
15. Wouda JC, Hartman PM, Bakker RM, Bakker JO, van de Wiel HBM, Weijmar Schultz WCM. Vaginal plethysmography in women with dyspareunie. J Sex Res 1998; 35: 141-7.
16. Alexander NJ, Baker E, Kaptein M, Karck U, Miller L, Zampaglione E. Why consider vaginal drug administration? Fertil Steril 2004; 82: 1-12.
17. Salehian B, Wang C, Alexander G, Davidson T, McDonald V, Berman N, Dudley RE, Ziel F, Swerdloff RS. Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: Comparison to testosterone enanthate - A clinical research center study. J Clin Endocrinol Metab 1995; 80: 3567-75.
18. Berman JR, Almeida FG, Jolin J, Raz S, Chaudhuri G, Gonzalez-Cadavid NF. Correlation of androgen receptors, aromatase, and 5-reductase in the human vagina with menopausal status. Fertil Steril 2003; 79: 925-31.
19. Tuiten A, van Honk J, Koppeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 2000; 57: 149-53.
20. Meston CM, Heiman JR. Acute dehydroepiandrosterone effects on sexual arousal in premenopausal women. J Sex Marital Ther 2002; 28: 53-60.
21. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666-72.
22. Laan E, Everaerd W, Evers A. Assessment of female sexual arousal: Response specificity and construct validity. Psychophysiology 1995; 32: 476-85.
23. Stuenkel CA, Dudley RE, Yen SSC. Sublingual administration of testosterone-hydroxylpropyl-β-cyclodextrin inclusion complex simulates episodic androgen release in hypogonadal men. J Clin Endocrinol Metab 1991; 72: 1054-9.
24. Wallen K, Parsons WA. Androgen may increase sexual motivation in estrogen-treated ovariectomized rhesus monkeys by increasing estrogen availability. Newport Beach, CA: Serono International Symposium on Biology of Menopause; 1998.
25. Dunn JF, Nisula BC, Rodbard D. Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981; 53: 58-68.
26. Wallen K, Parsons WA. Androgen may increase sexual motivation in estrogen-treated ovariectomized rhesus monkeys by increasing estrogen availability. Newport Beach, CA: Serono International Symposium on Biology of Menopause; 1998.