Biological and psychosocial pathophysiology of female sexual dysfunction during the menopausal transition

Journal of Sexual Medicine

Volumn 2, Issue SUPPL. 3, 2005, Pages 133-145

  Graziottin, Alessandra ^a,b   Leiblum, Sandra R ^c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c NONE

Author keywords

Estrogens; Female Sexual Disorders; Hormone Therapy; Menopause; Progestogens; Sexual Hormones; Sexuality; Testosterone

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; CYPROTERONE ACETATE; DESOGESTREL; DROSPIRENONE; DYDROGESTERONE; ESTRADIOL; GESTODENE; LEVONORGESTREL; MEDROGESTONE; MEDROXYPROGESTERONE ACETATE; MEGESTROL; NOMEGESTROL ACETATE; NORETHISTERONE; NORETHISTERONE ACETATE; NORGESTIMATE; PROGESTERONE; STEROID HORMONE; TESTOSTERONE;

CLIMACTERIUM; COMORBIDITY; ESTROGEN DEFICIENCY; FEMALE SEXUAL DYSFUNCTION; HEALTH STATUS; HUMAN; MEDICAL LITERATURE; OVARIECTOMY; PATHOPHYSIOLOGY; POSTMENOPAUSE; PRESCRIPTION; PRIORITY JOURNAL; PSYCHOSEXUAL DEVELOPMENT; REVIEW; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; SEXUALITY; SOCIAL STATUS; STEROID BLOOD LEVEL;

EID: 28444472708     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2005.00129.x     Document Type: Article

References (70)

1. Dennerstein L, Alexander JL, Kotz K. The menopause and sexual functioning: A review of the population-based studies. Annu Rev Sex Res 2003;14: 64-82.
2. Dennerstein L, Randolph J, Taffe J, Dudley E, Burger H. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 2002;77(suppl 4):S42-S48.
3. Palacios S, Tobar AC, Menendez C. Sexuality in the climacteric years. Maturitas 2002;43(suppl 1):S69-S77.
4. Basson R, Leiblum S, Brotto L, Derogatis L, Fourcroy J, Fugl-Meyer K, Graziottin A, Heiman JR, Laan E, Meston C, Schover L, van Lankveld J, Schultz WW. Definitions of women's sexual dysfunction reconsidered: Advocating expansion and revision. J Psychosom Obstet Gynaecol 2003;24: 221-9.
5. Lobo RA, Rosen RC, Yang HM, Block B, Van Der Hoop RG. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003;79:1341-52.
6. Graziottin A, Brotto LA. Vulvar vestibulitis syndrome: A clinical approach. J Sex Marital Ther 2004;30:125-39.
7. Graziottin A. Sexuality in postmenopause and senium. In: Lauritzen C, Studd J, editors. Current management of the menopause. London: Martin Dunitz; 2004:185-203.
8. Graziottin A. Dyspareunia: Clinical approach in the perimenopause. In: Studd J, editor. The management of the menopause. 3rd edition. London: Parthenon Publishing; 2003:229-41.
9. Graziottin A, Basson R. Sexual dysfunction in women with premature menopause. Menopause 2004;11:766-77.
10. Lobo RA. Treatment of the postmenopausal woman: Basic and clinical aspects. Philadelphia, PA: Lippincott Williams & Wilkins; 1999.
11. Alexander JL, Kotz K, Dennerstein L, Davis SR. The systemic nature of sexual functioning in the postmenopausal woman: Crossroads of psychiatry and gynecology. Primary Psychiatry 2003;10:53-7.
12. Simpson ER. Aromatization of androgens in women: Current concepts and findings. Fertil Steril 2002;77(suppl 4):S6-S10.
13. Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, Woods N. Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertil Steril 2001;76:874-8.
14. Burger HG, Dudley EC, Hopper JL, Groome N, Guthrie JR, Green A, Dennerstein L. Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. J Clin Endocrinol Metab 1999;84:4025-30.
15. Gronemeyer H, Gustafsson J-A, Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004;3:950-64.
16. Fiorini S, Ferretti ME, Biondi C, Pavan B, Lunghi L, Paganetto G, Abelli L. 17β-estradiol stimulates arachidonic acid release from human amnion-like WISH cells through a rapid mechanism involving a membrane receptor. Endocrinology 2003;144: 3359-67.
17. Koehler KF, Helguero LA, Haldosen L-A, Warner M, Gustafsson J-A. Reflection on the discovery and significance of estrogen receptor β. Endocr Rev 2005;26:465-78.
18. Tarcan T, Park K, Goldstein I, Maio G, Fassina A, Krane RJ, Azadzoi KM. Histomorphometric analysis of age-related structural changes in human clitoral cavernosal tissue. J Urol 1999;161:940-4.
19. Reay Jones NH, Healy JC, King LJ, Saini S, Shousha S, Allen-Mersh TG. Pelvic connective tissue resilience decreases with vaginal delivery, menopause and uterine prolapse. Br J Surg 2003;90: 466-72.
20. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999;281:537-44.
21. Kow LM, Pfaff DW. Effects of estrogen treatment on the size of receptive field and response threshold of pudendal nerve in the female rat. Neuroendocrinology 1973-74;13:299-313.
22. Gescheider GA, Verrillo RT, McCann JT, Aidrich EM. Effects of the menstrual cycle on vibrotactile sensitivity. Percept Psychophys 1984;36: 586-92.
23. Parlee MB. Menstrual rhythms in sensory processes: A review of fluctuations in vision, olfaction, audition, taste, and touch. Psychol Bull 1983;93:539-48.
24. Rubinow DR, Schmidt PJ, Roca CA. Estrogen-serotonin interactions: Implications for affective regulation. Biol Psychiatry 1998;44:839-50.
25. Rubinow DR, Schmidt PJ. Androgens, brain, and behavior. Am J Psychiatry 1996;153:974-84.
26. Burger HG. Androgen production in women. Fertil Steril 2002;77(suppl 4):S3-S5.
27. Bachmann GA. The hypoandrogenic woman: Pathophysiologic overview. Fertil Steril 2002; 77(suppl 4):S72-S6.
28. Traish AM, Kim N, Min K, Munarriz R, Goldstein I. Role of androgens in female genital sexual arousal: Receptor expression, structure, and function. Fertil Steril 2002;77(suppl 4):S11-S18.
29. Sarrel PM. Androgen deficiency: Menopause and estrogen-related factors. Fertil Steril 2002;77(suppl 4):S63-S67.
30. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 2000;85:2832-8.
31. Simon JA. Estrogen replacement therapy: Effects on the endogenous androgen milieu. Fertil Steril 2002;77(suppl 4):S77-S82.
32. Dennerstein L, Koochaki PE, Barton I, Graziottin A. Surgical menopause and female sexual functioning: A survey of western European women. Menopause (in press).
33. Graziottin A. Sexual desire disorders: Clinical approach. Female sexual dysfunction: Clinical approach. Urodinamica 2004;14:61-7.
34. Bancroft J. Sexual effects of androgens in women: Some theoretical considerations. Fertil Steril 2002;77(suppl 4):S55-S59.
35. Shifren JL, Braunstein GD, Simon JA, Casson PR, Buster JE, Redmond GP, Burki RE, Ginsburg ES, Rosen RC, Leiblum SR, Caramelli KE, Mazer NA. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-8.
36. Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: Effects on sexuality and well-being. Climacteric 2002;5:357-65.
37. Gerber JR, Johnson JV, Bunn JY, O'Brien SL. A longitudinal study of the effects of free testosterone and other psychosocial variables on sexual function during the natural traverse of menopause. Fertil Steril 2005;83:643-8.
38. Aziz A, Brannstrom M, Bergquist C, Silfverstolpe G. Perimenopausal androgen decline after oophorectomy does not influence sexuality or psychological well-being. Fertil Steril 2005;83: 1021-8.
39. Vehkavaara S, Hakala-Ala-Pietila T, Virkamaki A, Bergholm R, Ehnholm C, Hovatta O, Taskinen MR, Yki-Jarvinen H. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 2000;102:2687-93.
40. Simon J, Klaiber E, Wiita B, Bowen A, Yang HM. Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. Menopause 1999;6:138-46.
41. de Ziegler D, Fanchin R. Progesterone and progestins: Applications in gynecology. Steroids 2000;65:671-9.
42. Hammond GL, Rabe T, Wagner JD. Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy. Am J Obstet Gynecol 2001;185(2 suppl):S24-S31.
43. Schindler AE. Role of progestins in the premenopausal climacteric. Gynecol Endocrinol 1999;13 (suppl 6):S35-S40.
44. The North American Menopause Society. Role of progestogen in hormone therapy for postmenopausal women: Position statement of The North American Menopause Society. Menopause 2003;10: 113-32.
45. Goeretzlehner G. The role of progestogens in hormone replacement. Drugs Today 2001;37(suppl C):S1-S8.
46. Stanzczyk FZ. Pharmacokinetics and potency of progestins used for hormone replacement therapy and contraception. Rev Endocr Metab Disord 2002;3:211-24.
47. Graziottin A. The woman patient after WHI. Maturitas 2005;51(1):29-37.
48. Pan HA, Wu MH, Hsu CC, Yao BL, Huang KE. The perception of menopause among women in Taiwan. Maturitas 2002;41:269-74.
49. Chim H, Tan BH, Ang CC, Chew EM, Chong YS, Saw SM. The prevalence of menopausal symptoms in a community in Singapore. Maturitas 2002;41: 275-82.
50. Ho SC, Chan SG, Yip YB, Cheng A, Yi Q, Chan C. Menopausal symptoms and symptom clustering in Chinese women. Maturitas 1999;33:219-27.
51. Avis NE, Stellato R, Crawford S, Bromberger J, Ganz P, Cain V, Kagawa-Singer M. Is there a menopausal syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 2001;52:345-56.
52. Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG. A prospective population-based study of menopausal symptoms. Obstet Gynecol 2000;96:351-8.
53. Goonaratna C, Fonseka P, Wijeywardene K. Perimenopausal symptoms in Sri Lankan women. Ceylon Med J 1999;44:63-9.
54. Rymer J, Morris EP. Extracts from "Clinical evidence": Menopausal symptoms. BMJ 2000;321: 1516-19.
55. Sarrel PM. Sexuality and menopause. Obstet Gynecol 1990;75:26S-30S; discussion 31S-35S.
56. Vinker S, Kaplan B, Nakar S, Samuels G, Shapira G, Kitai E. Urinary incontinence in women: Prevalence, characteristics and effect on quality of life. A primary care clinic study. Isr Med Assoc J 2001;3:663-6.
57. Luna MT, Hirakawa T, Nakano H. Urinary incontinence in women seen in the obstetrics and gynecology clinic. Int Urogynecol J Pelvic Floor Dysfunct 2000;11:277-81.
58. Iosif CS, Bekassy Z. Prevalence of genito-urinary symptoms in the late menopause. Acta Obstet Gynecol Scand 1984;63:257-60.
59. Hextall A. Oestrogens and lower urinary tract function. Maturitas 2000;36:83-92.
60. Hay AG, Bancroft J, Johnstone EC. Affective symptoms in women attending a menopause clinic. Br J Psychiatry 1994;164:513-6.
61. Zhao G, Bao Y, Qu C. [Occurrence of depression symptoms and their influence factors in perimenopausal women]. Zhonghua Fu Chan Ke Za Zhi 1996;31:614-6 (in Chinese).
62. Bromberger JT, Assmann SF, Avis NE, Schocken M, Kravitz HM, Cordal A. Persistent mood symptoms in a multiethnic community cohort of pre- and perimenopausal women. Am J Epidemiol 2003;158:347-56.
63. Avis NE, Crawford S, Stellato R, Longcope C. Longitudinal study of hormone levels and depression among women transitioning through menopause. Climacteric 2001;4:243-9.
64. Joffe H, Hall JE, Soares CN, Hennen J, Reilly CJ, Carlson K, Cohen LS. Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care. Menopause 2002;9:392-8.
65. Davis SR. The effects of tibolone on mood and libido. Menopause 2002;9:162-70.
66. Dunn KM, Croft PR, Hackett GI. Association of sexual problems with social, psychological, and physical problems in men and women: A cross-sectional population survey. J Epidemiol Community Health 1999;53:144-8.
67. Althof S, Leiblum S, Chevert-Measson M, Hartman U, Levine S, McCae M, Flaut M, Rodrigues O, Wylie K. Psychological and interpersonal dimensions of sexual function and dysfunction. In: Lue T, Basson R, Rosen R, Giuliano F, Khoury S, Montorsi F, editors. Sexual medicine: Sexual dysfunction in men and women. 2nd International Consultation on Sexual Dysfunction: Health Publications, Paris, 2004.
68. Stuart FM, Hammond DC, Pett MA. Inhibited sexual desire in women. Arch Sex Behav 1987;16: 91-106.
69. Leiblum SR. Arousal disorders in women: Complaints and complexities. Med J Aust 2003;178:638-40.
70. Graziottin A. Female sexual dysfunction. In: Bo K, Berghmans B, Van Kampen M, Morkved S, editors. Evidence-based physiotherapy for the pelvic floor: Bridging research and clinical practice. Oxford: Elsevier; 2005 (in press).