An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 3, 2001, Pages 690-695

  Weitnauer, G ^a   Gaisser, S ^a   Trefzer, A ^a   Stockert, S ^a   Westrich, L ^a   Quiros, L M ^a   Mendez, C ^a   Salas, J A ^a   Bechthold, A ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; AVILAMYCIN; PHENYLALANINE; RNA METHYLTRANSFERASE;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; DRUG STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES LIVIDANS; STREPTOMYCES VIRIDOCHROMOGENES;

ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CHROMATOGRAPHY, AFFINITY; CLONING, MOLECULAR; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; RIBOSOMES; STREPTOMYCES;

EID: 0035119065     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.3.690-695.2001     Document Type: Article

References (30)

1. Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-1 and LS transport systems of Escherichia coli
2. Mutations in ribosomal protein L16 conferring reduced susceptibility to everninomicin (SCH27899): Implications for mechanism of action
3. Overexpression of the thiostrepton-resistance gene from Streptomyces azureas in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2′-methyltransferase in the guanosine triphosphatase center of 238 ribosomal RNA
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
5. Characterization of Streptomyces promoter sequences using the Escherichia coli galactokinase gene
6. Complete genome sequence of the methanogenic archaeon, Methunococcus jannaschii
7. Avilamycin
8. Everninomicin (SCH27899) inhibits both translation and 508 ribosomal subunit formation in Staphylococcus aureus cells
9. Sequence analysis of the Azospirillum brasilense exoB gene, encoding UDP-glucose 4′-epimerase
10. An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus
11. High efficiency intergenic conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes
12. Pharmacologic and bacteriologic properties of SCH-27899 (Ziracin), an investigational antibiotic from the everninomicin family
13. In vitro activities of SCH27899 alone and in combination with 17 other antimicrobial agents
14. Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57
15. A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin
16. Antimicrobial activity and spectrum of SCH27899 (ziracin) tested against gram-positive species including recommendations for routine susceptibility testing methods and quality control
17. SpoU protein of Escherichia coli belongs to a new family of putative rRNA methylases
18. Pharmacokinetics of an everninomicin (SCH 27899) in mice, rats, rabbits, and cynomologus monkeys following intravenous administration
19. Everninomicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria
20. ABC transporters in antibiotic-producing actinomycetes
21. Novel mechanisms of resistance to lincosamides in Staphylococcus and Arthrobacter spp.
22. Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily
23. Structure and role in symbiosis of the exoB gene of Rhizobium leguminosarum by trifolii
24. Function of glycosyltransferase genes involved in urdamycin A biosynthesis
25. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)
26. In vivo activity and pharmacokinetics of ziracin (SCH27899), a new long-acting everninomicin antibiotic, in a murine model of penicillin-susceptible or penicillin-resistant pneumococcal pneumonia
27. Avilamycin, an inhibitor of the 30S ribosomal subunit function
28. The orthosomycins, a new family of antibiotics