Adenosine receptors: Novel targets for drug development in allergic rhinitis

Clinical and Experimental Allergy

Volumn 37, Issue 1, 2007, Pages 4-7

  Matera, M G ^b   Polosa, R ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CORTICOSTEROID; CVT 6883; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHOLIPASE C; THEOPHYLLINE; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; CELL ACTIVATION; CELL SURFACE; CELLULAR IMMUNITY; CHEMOTAXIS; DRUG EFFICACY; DRUG TARGETING; EDITORIAL; EOSINOPHIL; GRANULOCYTE; HUMAN; INFLAMMATION; INFLAMMATORY CELL; LUNG LAVAGE; MAST CELL; MONONUCLEAR CELL; NONHUMAN; NOSE OBSTRUCTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; THROMBOCYTE AGGREGATION;

ADENOSINE; ASTHMA; CHRONIC DISEASE; HUMANS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RHINITIS; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; SIGNAL TRANSDUCTION;

EID: 33845723115     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2006.02647.x     Document Type: Editorial

References (24)

1. Newby AC. Adenosine and the concept of retaliatory metabolites. Trends Biochem Sci 1984; 9:42-4.
2. Driver AG, Kukoly CA, Ali S, Mustafa SJ. Adenosine in bronchoalveolar lavage fluid in asthma. Am Rev Respir Dis 1993; 148:91-7.
3. Huszar E, Vass G, Vizi E et al. Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur Respir J 2002; 20:1393-8.
4. Vass G, Huszar E, Barat E et al. Comparison of nasal and oral inhalation during exhaled breath condensate collection. Am J Respir Crit Care Med 2003; 167:850-5.
5. Crimi N, Polosa R, Mistretta A. Mechanisms of the effector function of adenosine in asthma and rhinitis. Drug Develop Res 1993; 28:322-7.
6. Polosa R, Pagano C, Dokic D, Prosperini G, Church MK, Crimi N. Histamine release upon AMP nasal provocation in allergic subjects. Thorax 1999; 54:230-3.
7. Russo C, Zeng D, Prosperini G, Spicuzza L, Guarino F, Polosa R. Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5′ monophosphate nasal challenge. Clin Exp Allergy 2005; 35:1192-6.
8. Lee DK, Gardiner M, Haggart K, Fujihara S, Lipworth BJ. Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis. Clin Exp Allergy 2004 Apr; 34:650-3.
9. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001; 53:527-52.
10. El-Hashim A, D'Agostino B, Matera MG, Page C. Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits. Br J Pharmacol 1996; 119:1262-8.
11. Nyce JW, Metzger WJ. DNA antisense therapy for asthma in an animal model. Nature 1997; 385:721-5.
12. Fredholm BB, Zhang Y, Van Der Ploeg L. Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes. Naunyn Schmiedebergs Arch Pharmacol 1996; 354:262-7.
13. Bouma MG, Jeunhomme TM, Boyle DL et al. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of A2 and A3 receptors. J Immunol 1997; 158:5400-8.
14. 2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol 2002; 438:183-8.
15. 2B adenosine receptor signaling in adenosine dependent pulmonary inflammation and injury. J Clin Invest 2006; 116:2173-82.
16. Feoktistov I, Polosa R, Holagate ST, Biaggioni I. Adenosine A2B receptors: a novel therapeutic target in sthma? Tips 1998; 19:148-53.
17. 3 receptor subtype. Current Topics in Medicinal Chemistry 2003; 3:463-9.
18. Kohno Y, Ji X, Mawhorter SD, Koshiba M, Jacobson KA. Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium Blood 1996; 88:3569-74.
19. Walker BA, Jacobson MA, Knight DA et al. Adenosine A3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol 1997; 16:531-7.
20. Ezeamuzie CI, Philips E. Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release. Br J Pharmacol 1999; 127:188-94.
21. Russo C, Arcidiacono G, Polosa R. Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma. Fundam Clin Pharmacol 2006 Feb; 20:9-19.
22. Naclerio RM, Bartenfelder D, Proud D et al. Theophylline reduces histamine release during pollen-induced rhinitis. J Allergy Clin Immunol 1986; 78:874-6.
23. Aubier M, Neukirch C, Maachi M et al. Effect of slow-release theophylline on nasal antigen challenge in subjects with allergic rhinitis. Eur Respir J 1998; 11:1105-10.
24. Rimmer J, Peake HL, Santos CM et al. Targeting adenosine receptors in the treatment of allergic rhinitis: a randomised, double blind, placebo-controlled study. Clin Exp Allergy 2007; 37:8-14.