TGFβ1 and TGFα contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium

International Journal of Cancer

Volumn 120, Issue 3, 2007, Pages 493-499

  Booth, Brian W ^a   Jhappan, Chamelli ^a   Merlino, Glenn ^a   Smith, Gilbert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; Mammary; TGF; Transgenic

Indexed keywords

TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; GROWTH REGULATION; GROWTH STIMULATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; APOPTOSIS; EPITHELIUM; EXPERIMENTAL NEOPLASM; GENETICS; GENOTYPE; HUMAN; MALE; METABOLISM; MOUSE STRAIN; PATHOLOGY; PHENOTYPE; PRECANCER; UDDER;

ANIMALS; APOPTOSIS; CELL SURVIVAL; EPITHELIUM; FEMALE; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; PHENOTYPE; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33845710652     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22310     Document Type: Article

References (29)

1. Humphreys RC, Hennighausen L. Transforming growth factor-α and mouse models of human hreast cancer. Oncogene 2000;19:1085-91.
2. Jhappan C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT. TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 1990;61:1137-46.
3. Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ. Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice. Cell 1990;61:1147-55.
4. Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC. Overexpression of TGFα in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990;61:1121-35.
5. Schroeder JA, Lee DC. Transgenic mice reveal roles for TGFα and EGF receptor in mammary gland development and neoplasia. J Mammary Gland Biol Neoplasia 1997;2:119-29.
6. Benson JR. Role of transforming growth factor-β in breast carcinogenesis. Lancet Oncol 2004;5:229-39.
7. Jhappan C, Geiser AG, Kordon EC, Bagheri D, Hennighausen L, Roberts AB, Smith GH, Merlino G. Targeting expression of a transforming growth factor-β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J 1993;12:1835-45.
8. Pierce DF, Jr, Gorska AE, Chytil A, Meise KS, Page DL, Coffey RJ, Jr, Moses HL. Mammary tumor suppression by transforming growth factor-β1 transgenic expression. Proc Natl Acad Sci USA 1995;92:4254-8.
9. Davies M, Robinson M, Smith E, Huntley S, Prime S, Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGFβ1 involves MAPK, Smad and AP-1 signalling pathways. J Cell Biochem 2005;95:918-31.
10. Han G, Lu SL, Li AG, He W, Corless CL, Kulesz-Martin M, Wang XJ. Distinct mechanisms of TGFβ1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest 2005;115:1714-23.
11. Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, Lee HB. Role of reactive oxygen species in TGFβ1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renat tubular epithelial cells. J Am Soc Nephrol 2005;16:667-75.
12. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005;166:1321-32.
13. Coffey RJ, Jr. Sipes NJ, Bascom CC, Graves-Deal R, Pennington CY, Weissman BE, Moses HL. Growth modulation of mouse keratinocytes by transforming growth factors. Cancer Res 1988;48:1596-602.
14. DeOme KB, Faulkin LJ, Jr. Bern HA, Blair PB. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res 1959;19:515-20.
15. Daniel CW, De Ome KB, Young JT, Blair PB, Faulkin LJ, Jr. The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. Proc Natl Acad Sci USA 1968;61:53-4.
16. Smith GH, Gallahan D, Zwiebel JA, Freeman SM, Bassin RH, Callahan R. Long-term in vivo expression of genes introduced by retrovirus-mcdiated transfer into mammary epithelial cells. J Virol 1991;65:6365-70.
17. Smith GH. Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res Treat 1996;39:21-31.
18. Smith GH, Sharp R, Kordon EC, Jhappatt C, Merlino G. Transforming growth factor-α promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells. Am J Pathol 1995;147:1081-96.
19. Boulanger CA, Smith GH. Reducing mammary cancer risk through premature stem cell senescence. Oncogene 2001;20:2264-72.
20. Plath A, Einspanier R, Peters F, Sinowatz F, Schams D. Expression of transforming growth factors α and β-1 messenger RNA in the bovine mammary gland during different stages of development and lactation. J Endocrinol 1997;155:501-11.
21. Coffey RJ, Jr. Meise KS, Matsui Y, Hogan BL, Dempsey PJ, Halter SA. Acceleration of mammary neoplasm in transforming growth factor-α transgenic mice by 7,12-dimethylbenzanthracene. Cancer Res 1994;54:1678-83.
22. Girande JP. Role of transforming growth factor-β in tissue injury and repair. Proc Soc Exp Biol Med 1997;214:27-40.
23. Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH. Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol 1995;168:47-61.
24. Buggiano V, Schere-Levy C, Abe K, Vanzulli S, Piazzon I, Smith GH, Kordon EC. Impairment of mammary lobular development induced by expression of TGFβ1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice. Int J Cancer 2001;92:568-76.
25. Massague J, Chen YG. Controlling TGFβ signaling. Genes Dev 2000;14:627-44.
26. Kretzschmar M, Doody J, Massague J. Opposing BMP and EGF signalling pathways converge on the TGFβ family mediator Smad1. Nature 1997;389:618-22.
27. Kretzschmar M, Doody J, Timokhina I, Massagne J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999;13:804-16.
28. Cheng N, Bhowmick NA, Chytil A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL. Loss of TGFβ type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGFα-, MSP- and HGF-mediated signaling networks. Oncogene 2005;24:5053-68.
29. Mieth M, Boehmer FD, Ball R, Groner B, Grosse R. Transforming growth factor-β inhibits lactogenic hormone induction of β-casein expression in HCl I mouse mammary epithelial cells. Growth Factors 1990;4:9-15.