Tolerizing DNA vaccines for autoimmune arthritis

Autoimmunity

Volumn 39, Issue 8, 2006, Pages 675-682

  Ho, Peggy P ^a   Higgins, John P ^a   Kidd, Brian A ^a,b   Tomooka, Beren ^a,b   DiGennaro, Carla ^a   Lee, Lowen Y ^a   de Vegvar, Henry E Neuman ^a,b   Steinman, Lawrence ^a   Robinson, William H ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Autoantibodies; DNA vaccine; Proteomics; Rheumatoid arthritis

Indexed keywords

ANTIGEN; ATORVASTATIN; AUTOANTIBODY; COLLAGEN; COLLAGEN TYPE 2; CYTOKINE; DNA VACCINE; FREUND ADJUVANT; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG DESIGN; DRUG POTENTIATION; DRUG TARGETING; IMMUNE DEFICIENCY; IMMUNOLOGICAL TOLERANCE; INCIDENCE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROTEIN MICROARRAY; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; TREATMENT RESPONSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; COLLAGEN; CYTOKINES; HEPTANOIC ACIDS; HINDLIMB; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-4; JOINTS; MALE; MICE; MICE, INBRED DBA; PROTEIN ARRAY ANALYSIS; PYRROLES; SYSTEMS BIOLOGY; VACCINES, DNA;

EID: 33845698334     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930601061603     Document Type: Article

References (34)

1. Tang, DC and DeVit, M and Johnston, SA. (1992) Genetic immunization is a simple method for eliciting an immune response Nature, 356(6365), pp. 152-154.
2. McDonnell, WM and Askari, FK. (1996) DNA vaccines N Engl J Med, 334(1), pp. 42-45.
3. Robinson, HL and Torres, CA. (1997) DNA vaccines Semin Immunol, 9(5), pp. 271-283.
4. Ramshaw, IA and Fordham, SA and Bernard, CC and Maguire, D and Cowden, WB and Willenborg, DO. (1997) DNA vaccines for the treatment of autoimmune disease Immunol Cell Biol, 75(4), pp. 409-413.
5. Ruiz, PJ and Garren, H and Ruiz, IU and Hirschberg, DL and Nguyen, LV and Karpuj, MV and Cooper, MT and Mitchell, DJ and Fathman, CG and Steinman, L. (1999) Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: Modulation of T cell costimulation J Immunol, 162(6), pp. 3336-3341.
6. Garren, H and Ruiz, PJ and Watkins, TA and Fontoura, P and Nguyen, LT and Estline, ER and Hirschberg, DL and Steinman, L. (2001) Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway Immunity, 15(1), pp. 15-22.
7. Urbanek-Ruiz, I and Ruiz, PJ and Paragas, V and Garren, H and Steinman, L and Fathman, CG. (2001) Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice Clin Immunol, 100(2), pp. 164-171.
8. Balasa, B and Boehm, BO and Fortnagel, A and Karges, W and Van Gunst, K and Jung, N and Camacho, SA and Webb, SR and Sarvetnick, N. (2001) Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection Clin Immunol, 99(2), pp. 241-252.
9. Bot, A and Smith, D and Bot, S and Hughes, A and Wolfe, T and Wang, L and Woods, C and von Herrath, M. (2001) Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice J Immunol, 167(5), pp. 2950-2955.
10. Robinson, WH and Fontoura, P and Lee, BJ and de Vegvar, HE and Tom, J and Pedotti, R and DiGennaro, CD and Mitchell, DJ and Fong, D and Ho, PP and (2003) Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis Nat Biotechnol, 21(9), pp. 1033-1039.
11. Ho, PP and Fontoura, P and Platten, M and Sobel, RA and DeVoss, JJ and Lee, LY and Kidd, BA and Tomooka, BH and Capers, J and Agrawal, A and (2005) A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease J Immunol, 175(9), pp. 6226-6234.
12. Pahan, K and Sheikh, FG and Namboodiri, AM and Singh, I. (1997) Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages J Clin Invest, 100(11), pp. 2671-2679.
13. Stanislaus, R and Pahan, K and Singh, AK and Singh, I. (1999) Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin Neurosci Lett, 269(2), pp. 71-74.
14. Youssef, S and Stuve, O and Patarroyo, JC and Ruiz, PJ and Radosevich, JL and Hur, EM and Bravo, M and Mitchell, DJ and Sobel, RA and Steinman, L and (2002) The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease Nature, 420(6911), pp. 78-84.
15. Leung, BP and Sattar, N and Crilly, A and Prach, M and McCarey, DW and Payne, H and Madhok, R and Campbell, C and Gracie, JA and Liew, FY and (2003) A novel anti-inflammatory role for simvastatin in inflammatory arthritis J Immunol, 170(3), pp. 1524-1530.
16. Stuve, O and Youssef, S and Weber, MS and Nessler, S and von Budingen, HC and Hemmer, B and Prod'homme, T and Sobel, RA and Steinman, L and Zamvil, SS. (2006) Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity J Clin Invest, 116(4), pp. 1037-1044.
17. Coon, B and An, LL and Whitton, JL and von Herrath, MG. (1999) DNA immunization to prevent autoimmune diabetes J Clin Invest, 104(2), pp. 189-194.
18. Karges, W and Pechhold, K and Al Dahouk, S and Riegger, I and Rief, M and Wissmann, A and Schirmbeck, R and Barth, C and Boehm, BO. (2002) Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice Diabetes, 51(11), pp. 3237-3244.
19. Wolfe, T and Bot, A and Hughes, A and Mohrle, U and Rodrigo, E and Jaume, JC and Baekkeskov, S and von Herrath, M. (2002) Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: Addition of IL-4 increases safety Eur J Immunol, 32(1), pp. 113-121.
20. Ragno, S and Colston, MJ and Lowrie, DB and Winrow, VR and Blake, DR and Tascon, R. (1997) Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65 Arthritis Rheum, 40(2), pp. 277-283.
21. Quintana, FJ and Cohen, IR. (2005) DNA vaccines coding for heat-shock proteins (HSPs): Tools for the activation of HSP-specific regulatory T cells Expert Opin Biol Ther, 5(4), pp. 545-554.
22. Courtenay, JS and Dallman, MJ and Dayan, AD and Martin, A and Mosedale, B. (1980) Immunisation against heterologous type II collagen induces arthritis in mice Nature, 283(5748), pp. 666-668.
23. Myers, LK and Rosloniec, EF and Cremer, MA and Kang, AH. (1997) Collagen-induced arthritis, an animal model of autoimmunity Life Sci, 61(19), pp. 1861-1878.
24. Morgan, K and Clague, RB and Collins, I and Ayad, S and Phinn, SD and Holt, PJ. (1987) Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis Ann Rheum Dis, 46(12), pp. 902-907.
25. Tarkowski, A and Klareskog, L and Carlsten, H and Herberts, P and Koopman, WJ. (1989) Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis Arthritis Rheum, 32(9), pp. 1087-1092.
26. Burkhardt, H and Koller, T and Engstrom, A and Nandakumar, KS and Turnay, J and Kraetsch, HG and Kalden, JR and Holmdahl, R. (2002) Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse Arthritis Rheum, 46(9), pp. 2339-2348.
27. Wooley, PH and Luthra, HS and Stuart, JM and David, CS. (1981) Type II Major histocompatibility complex (I region) linkage and antibody correlates J Exp Med, 154(3), pp. 688-700.
28. Hueber, W and Kidd, BA and Tomooka, BH and Lee, BJ and Bruce, B and Fries, JF and Sonderstrup, G and Monach, P and Drijfhout, JW and van Venrooij, WJ and (2005) Antigen microarray profiling of autoantibodies in rheumatoid arthritis Arthritis Rheum, 52(9), pp. 2645-2655.
29. Eisen, MB and Spellman, PT and Brown, PO and Botstein, D. (1998) Cluster analysis and display of genome-wide expression patterns Proc Natl Acad Sci USA, 95(25), pp. 14863-14868.
30. Kim, SH and Kim, S and Evans, CH and Ghivizzani, SC and Oligino, T and Robbins, PD. (2001) Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4 J Immunol, 166(5), pp. 3499-3505.
31. Watanabe, S and Imagawa, T and Boivin, GP and Gao, G and Wilson, JM and Hirsch, R. (2000) Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium Mol Ther, 2(2), pp. 147-152.
32. McCarey, DW and McInnes, IB and Madhok, R and Hampson, R and Scherbakov, O and Ford, I and Capell, HA and Sattar, N. (2004) Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-blind, randomised placebo-controlled trial Lancet, 363(9426), pp. 2015-2021.
33. Kremer, JM and Westhovens, R and Leon, M and Di Giorgio, E and Alten, R and Steinfeld, S and Russell, A and Dougados, M and Emery, P and Nuamah, IF and (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig N Engl J Med, 349(20), pp. 1907-1915.
34. Kuhn, KA and Kulik, L and Tomooka, B and Braschler, KJ and Arend, WP and Robinson, WH and Holers, VM. (2006) Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis J Clin Invest, 116(4), pp. 961-973.