PHEX endopeptidase

Handbook of Proteolytic Enzymes, Second Edition: Volume 1: Aspartic and Metallo Peptidases

Volumn 1, Issue , 2004, Pages 438-440

  Boileau, Guy ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845667178     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-079611-3.50121-X     Document Type: Chapter

References (22)

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2. L. Beck, Y. Soumounou, J. Martel, G. Krishnamurthy, C. Gauthier, C.G. Goodyer and H.S. Tenenhouse (1997) Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J. Clin. Invest. 99 1200-1209.
3. G. Boileau, H.S. Tenenhouse, L. DesGroseillers and P. Crine (2001) Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107–139as a substrate and osteocalcin, PPi and phosphate as inhibitors. Biochem. J. 355 707-713.
4. A.E. Bowe, R. Finnegan, S.M. Jan de Beur, J. Cho, M.A. Levine, R. Kumar and S.C. Schiavi (2001) FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem. Biophys. Res. Commun. 284 977-981.
5. M. Campos, C. Couture, I.Y. Hirata, M.A. Juliano, T.P. Loisel, P. Crine, L. Juliano, G. Boileau and A.K. Carmona (2003) Human recombinant PHEX has a strict S1′ specificity for acidic residues and cleaves peptides derived from FGF-23 and MEPE. Biochem J. 373 271-279.
6. P. Crine, N. Dion and G. Boileau (1997) Endopeptidase-24.11. A.J. Kenny, C.M. Boustead (Eds) Cell-Surface Peptidases in Health and Disease Oxford: BIOS Scientific 79-98.
7. B. Ecarot and M. Desbarats (1999) 1,25-(OH)2 D3down-regulates expression of Phex, a marker of the mature osteoblast. Endocrinology 140 1192-1199.
8. F. Francis, T.M. Strom, S. Hennig, A. Boddrich, B. Lorenz, O. Brandau, K.L. Mohnike, M. Cagnoli, C. Steffens, S. Klages, K. Borzym, T. Pohl, C. Oudet, M.J. Econs, P.S.N. Rowe, R. Reinhardt, T. Meitinger and H. Lehrach (1997) Genomic organization of the human PEX gene mutated in X-linked hypophosphatemia. Genome Res. 7 573-585.
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12. HYP, Consortium (1995) A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nature Genet. 11, 130–136
13. M.L. Lipman, D. Panda, H.P.J. Bennett, J.E. Henderson, E. Shane, Y. Shen, D. Goltzman and A.C. Karaplis (1998) Cloning of human Pex cDNA. Expression, subcellular localization, and endopeptidase activity. J. Biol. Chem. 273 13729-13737.
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15. C. Oefner, A. D'Arcy, M. Hennig, F.K. Winkler and G.E. Dale (2000) Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon. J. Mol. Biol. 296 341-349.
16. A.F. Ruchon, M. Marcinkiewicz, G. Siegfried, H.S. Tenenhouse, L. DesGroseillers, P. Crine and G. Boileau (1998) Pex mRNA is localized in developing mouse osteoblasts and odontoblasts. J. Histochem. Cytochem. 46 459-468.
17. A.F. Ruchon, H.S. Tenenhouse, M. Marcinkiewicz, G. Siegfried, J.E. Aubin, L. DesGroseillers, P. Crine and G. Boileau (2000) Developmental expression and tissue distribution of Phex protein: Effect of the Hyp mutation and relationship to bone markers. J. Bone Miner. Res. 15 1440-1450.
18. Y. Sabbagh, G. Boileau, L. DesGroseillers and S. Tenenhouse (2001) Disease-causing missense mutations in the PHEX gene interfere with membrane targeting of the recombinant protein. Hum. Mol. Genet. 10 1539-1546.
19. T. Shimada, S. Mizutani, T. Muto, T. Yoneya, R. Hino, S. Takeda, Y. Takeuchi, T. Fujita, S. Fukumoto and T. Yamashita (2001) Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl. Acad. Sci. USA 98 6500-6505.
20. K. Shirotani, S. Tsubuki, N. Iwata, Y. Takaki, W. Harigaya, K. Maruyama, S. Kiryu-Seo, H. Kiyama, H. Iwata, T. Tomita, T. Iwatsubo and T.C. Saido (2001) Neprilysin degrades both amyloid β peptides 1–40 and 1–42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J. Biol. Chem. 276 21895-21901.
21. H.S. Tenenhouse (1999) X-linked hypophosphatemia: a homologous disorder in humans and mice. Nephrol. Dial. Transplant. 14 333-341.
22. D.L. Thompson, Y. Sabbagh, H.S. Tenenhouse, P.C. Roche, M.K. Drezner, J.L. Salisbury, J.P. Grande, E.M. Poeschla and R. Kumar (2002) Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. J. Bone Miner. Res. 17 311-320.