Conversion of potent MMP inhibitors into selective TACE inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 1028-1031

  Cherney, Robert J ^a   King, Bryan W ^a   Gilmore, John L ^a   Liu, Rui Qin ^a   Covington, Maryanne B ^a   Duan, James J W ^a   Decicco, Carl P ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

ADAM 17 inhibitor; TACE inhibitor

Indexed keywords

2 METHYL 4 QUINOLINYLMETHOXYPHENYL; BENZENE DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE; SULTAM HYDROXAMATE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION;

ADAM PROTEINS; DRUG DESIGN; ENZYME INHIBITORS; HYDROXAMIC ACIDS; METALLOPROTEASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 30344439523     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.078     Document Type: Article

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