Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: A potential role for ABCA7 in epidermal lipid reorganization

Journal of Investigative Dermatology

Volumn 121, Issue 3, 2003, Pages 465-474

  Kielar, Danuta ^a   Kaminski, Wolfgang E ^a   Liebisch, Gerhard ^a   Piehler, Armin ^a   Wenzel, Jürgen J ^a   Möhle, Christoph ^a   Heimerl, Susanne ^a   Langmann, Thomas ^a   Friedrich, Sven O ^a   Böttcher, Alfred ^a   Barlage, Stefan ^a   Drobnik, Wolfgang ^a   Schmitz, Gerd ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adenosine triphosphate binding cassette transporters; Epidermal lipids; Keratinocyte differentiation; Lipid transport

Indexed keywords

ABC TRANSPORTER; ABCA7 TRANSPORTER; ABCB1 TRANSPORTER; ABCC1 TRANSPORTER; ABCC3 TRANSPORTER; ABCC4 TRANSPORTER; ABCG1 TRANSPORTER; CERAMIDE; CHOLESTEROL; FATTY ACID; GLYCEROPHOSPHOLIPID; MESSENGER RNA; PHOSPHATIDYLSERINE; SPHINGOLIPID; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KERATINIZATION; KERATINOCYTE; LIPID TRANSPORT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; STRATUM CORNEUM;

EID: 0041333169     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12404.x     Document Type: Article

References (39)

1. Baron JM, Holler D, Schiffer R, Frankenberg S, Neis M, Merk HF, Jugert FK: Expression of multiple cytochrome p450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. 116:541-548, 2001
2. Bergen AA, Plomp AS, Schuurman EJ, et al: Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet 25:228-231, 2000
3. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1956
4. Boyce ST, Ham RG: Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J Invest Dermatol 81:33s-40s, 1983
5. Brügger B, Erben G, Sandhoff R, Wieland FT, Lehmann WD: Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci USA 94:2339-2344, 1997
6. Candi E, Tarcsa E, Idler WW, Kartasova T, Marekov LN, Steinert PM: Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin. J Biol Chem 274:7226-7237, 1999
7. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
8. Cuvillier O, Pirianov G, Kleuser B, Vanek PC, Coso OA, Gutkind S, Spiegel S: Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800-803, 1996
9. Di Nardo A, Benassi L, Magnoni C, Cossarizza A, Seidenari S, Giannetti A: Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. Br J Dermatol 143:491-497, 2000
10. Hannun YA, Luberto C, Argraves KM: Enzymes of sphingolipid metabolism: From modular to integrative signaling. Biochemistry 40:4893-4903, 2001
11. Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR: Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol 109:783-787, 1997
12. Harris IR, Farrell AM, Memon RA, Grunfeld C, Elias PM, Feingold KR: Expression and regulation of mRNA for putative fatty acid transport related proteins and fatty acyl CoA synthase in murine epidermis and cultured human keratinocytes. J Invest Dermatol 111:722-726, 1998
13. van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P, van Meer G: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87:507-517, 1996
14. Herrmann T, Van Der Hoeven F, Grone HJ, et al: Mice with targeted disruption of the fatty acid transport protein 4 (FATP4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol 161:1105-1115, 2003
15. Jarvis WD, Grant S, Kolesnick RN: Ceramide and the induction of apoptosis. Clin Cancer Res 2:1-6, 1996
16. Jensen JM, Schutze S, Forl M, Kronke M, Proksch E: Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104:1761-1770, 1999
17. Kaminski WE, Orso E, Diederich W, Klucken J, Drobnik W, Schmitz G: Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem Biophys Res Commun 273:532-538, 2000
18. Klucken J, Buchler C, Orso E, et al: ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97:817-822, 2000
19. Kolesnick R, Hannun YA: Ceramide and apoptosis. Trends Biochem Sxi 24:224-225, 1999
20. König J, Nies AT, Cui Y, Leier I, Keppler D: Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377-394, 1999
21. Kreder D, Krut O, Adam-Klages S, et al: Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J 18:2472-2479, 1999
22. Langmann T, Klucken J, Reil M, et al: Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun 257:29-33, 1999
23. Le Saux O, Urban Z, Tschuch C, et al: Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet 25:223-227, 2000
24. Lee MJ, Thangada S, Claffey KP, et al: Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99:301-312, 1999
25. Liebisch G, Drobnik W, Reil M, et al: Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS). J Lipid Res 40:1539-1546, 1999
26. Menon GK, Ghadially R, Williams ML, Elias PM: Lamellar bodies as delivery systems of hydrolytic enzymes: Implications for normal and abnormal desquamarion. Br J Dermatol 126:337-345, 1992
27. Mosser J, Douar AM, Sarde CO, et al: Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 361:726-730, 1993
28. Orso E, Broccardo C, Kaminski WE, et al: Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice. Nat Genet 24:192-196, 2000
29. Ringpfeil F, Lebwohl MG, Christiano AM, Uitto J: Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci USA 97:6001-6006, 2000
30. Robinson NA, Lapic S, Welter JF, Eckert RL: S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. J Biol Chem 272:12035-12046, 1997
31. Schaffer JE, Lodish HF: Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79:427-436, 1994
32. Schmitz G, Kaminski WE: ABC transporters and cholesterol metabolism. Front Biosci 6:505-D514, 2001
33. Schmitz G, Kaminski WE, Orso E: ABC transporters in cellular lipid trafficking. Curr Opin Lipidol 11:493-501, 2000
34. Schmuth M, Man MQ, Weber F, et al: Permeability barrier disorder in Niemann-Pick disease: Sphingomyelin-ceramide processing required for normal barrier homeostasis. J Invest Dermatol 115:459-466, 2000
35. Schurer NY, Elias PM: Skin lipids. In: Elias P (eds). The Biochemistry and Function of Stratum Corneum Lipids. Advances in Lipid Research 24. San Diego: Academic Press, 2001, pp 27-56
36. Szakacs G, Langmann T, Ozvegy C, Orso E, Schmitz G, Varadi A, Sarkadi B: Characterization of the ATPase cycle of human ABCA1: Implications for its function as a regulator rather than an active transporter. Biochem Biophys Res Commun 288:1258-1264, 2001
37. Tarcsa E, Candi E, Kartasova T, Idler WW, Marekov LN, Steinert PM: Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins. J Biol Chem 273:23297-23303, 1998
38. Uchida Y, Hara M, Nishio H, et al: Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41:2071-2082, 2000
39. Yamano G, Funahashi H, Kawanami O, et al: ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells. FEBS Lett 508:221-225, 2001