Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists

Cardiovascular Research

Volumn 73, Issue 1, 2007, Pages 217-226

  Krom, Yvonne D ^a   Pires, Nuno M M ^a,b   Jukema, J Wouter ^a   de Vries, Margreet R ^b   Frants, Rune R ^a   Havekes, Louis M ^a,b   van Dijk, Ko Willems ^a   Quax, Paul H A ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Animal model; Estrogens; Hormones; Receptors; Restenosis

Indexed keywords

2,3 BIS(4 HYDROXYPHENYL)PROPIONITRILE; 4,4',4'' (4 PROPYL [1H] PYRAZOLE 1,3,5 TRIYL)TRIS PHENOL; ANTIESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; METHYLPIPERIDINOPYRAZOLE; PHENOL DERIVATIVE; PROPIONITRILE; PYRAZOLE DERIVATIVE;

AGONIST; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CUFF; DOSE RESPONSE; DRUG ELUTING STENT; FEMORAL ARTERY; HORMONE INHIBITION; INTIMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; SENSITIVITY AND SPECIFICITY;

ANIMALS; CELL PROLIFERATION; DRUG IMPLANTS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMORAL ARTERY; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NITRILES; PROPIONATES; PYRAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUNICA INTIMA;

EID: 33845568106     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.10.024     Document Type: Article

References (34)

1. Dai-Do D., Espinosa E., Liu G., Rabelink T.J., Julmy F., Yang Z., et al. 17 beta-estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males. Cardiovasc Res 32 (1996) 980-985
2. Oparil S., Chen S.J., Chen Y.F., Durand J.N., Allen L., and Thompson J.A. Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries. Cardiovasc Res 44 (1999) 608-614
3. Mendelsohn M.E., and Karas R.H. The protective effects of estrogen on the cardiovascular system. N Engl J Med 340 (1999) 1801-1811
4. Mori T., Durand J., Chen Y., Thompson J.A., Bakir S., and Oparil S. Effects of short-term estrogen treatment on the neointimal response to balloon injury of rat carotid artery. Am J Cardiol 85 (2000) 1276-1279
5. Akishita M., Ouchi Y., Miyoshi H., Kozaki K., Inoue S., Ishikawa M., et al. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells. Atherosclerosis 130 (1997) 1-10
6. Farhat M.Y., Vargas R., Dingaan B., and Ramwell P.W. In vitro effect of oestradiol on thymidine uptake in pulmonary vascular smooth muscle cell: role of the endothelium. Br J Pharmacol 107 (1992) 679-683
7. Ling S., Dai A., Dilley R.J., Jones M., Simpson E., Komesaroff P.A., et al. Endogenous estrogen deficiency reduces proliferation and enhances apoptosis-related death in vascular smooth muscle cells: insights from the aromatase-knockout mouse. Circulation 109 (2004) 537-543
8. Morey A.K., Pedram A., Razandi M., Prins B.A., Hu R.M., Biesiada E., et al. Estrogen and progesterone inhibit vascular smooth muscle proliferation. Endocrinology 138 (1997) 3330-3339
9. Luconi M., Forti G., and Baldi E. Genomic and nongenomic effects of estrogens: molecular mechanisms of action and clinical implications for male reproduction. J Steroid Biochem Mol Biol 80 (2002) 369-381
10. Kushner P.J., Agard D.A., Greene G.L., Scanlan T.S., Shiau A.K., Uht R.M., et al. Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74 (2000) 311-317
11. Matthews J., and Gustafsson J.A. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv 3 (2003) 281-292
12. Tremblay G.B., Tremblay A., Copeland N.G., Gilbert D.J., Jenkins N.A., Labrie F., et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol 11 (1997) 353-365
13. Liu M.M., Albanese C., Anderson C.M., Hilty K., Webb P., Uht R.M., et al. Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 277 (2002) 24353-24360
14. Brouchet L., Krust A., Dupont S., Chambon P., Bayard F., and Arnal J.F. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 103 (2001) 423-428
15. Karas R.H., Hodgin J.B., Kwoun M., Krege J.H., Aronovitz M., Mackey W., et al. Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A 96 (1999) 15133-15136
16. Karas R.H., Schulten H., Pare G., Aronovitz M.J., Ohlsson C., Gustafsson J.A., et al. Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice. Circ Res 89 (2001) 534-539
17. Pare G., Krust A., Karas R.H., Dupont S., Aronovitz M., Chambon P., et al. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ Res 90 (2002) 1087-1092
18. Stauffer S.R., Coletta C.J., Tedesco R., Nishiguchi G., Carlson K., Sun J., et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem 43 (2000) 4934-4947
19. Meyers M.J., Sun J., Carlson K.E., Marriner G.A., Katzenellenbogen B.S., and Katzenellenbogen J.A. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44 (2001) 4230-4251
20. Harrington W.R., Sheng S., Barnett D.H., Petz L.N., Katzenellenbogen J.A., and Katzenellenbogen B.S. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol 206 (2003) 13-22
21. Moroi M., Zhang L., Yasuda T., Virmani R., Gold H.K., Fishman M.C., et al. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest 101 (1998) 1225-1232
22. Quax P.H., Lamfers M.L., Lardenoye J.H., Grimbergen J.M., de Vries M.R., Slomp J., et al. Adenoviral expression of a urokinase receptor-targeted protease inhibitor inhibits neointima formation in murine and human blood vessels. Circulation 103 (2001) 562-569
23. Pires N.M., van der Hoeven B.L., de Vries M.R., Havekes L.M., van Vlijmen B.J., Hennink W.E., et al. Local perivascular delivery of anti-restenotic agents from a drug-eluting poly(epsilon-caprolactone) stent cuff. Biomaterials 26 (2005) 5386-5394
24. Pires N.M., Schepers A., van der Hoeven B.L., de Vries M.R., Boesten L.S., Jukema J.W., et al. Histopathologic alterations following local delivery of dexamethasone to inhibit restenosis in murine arteries. Cardiovasc Res 68 (2005) 415-424
25. Fischer J.W. Dexamethasone: effects on neointimal hyperplasia and vessel integrity. Cardiovasc Res 68 (2005) 350-352
26. Monraats P.S., Pires N.M., Schepers A., Agema W.R., Boesten L.S., de Vries M.R., et al. Tumor necrosis factor-alpha plays an important role in restenosis development. FASEB J 19 (2005) 1998-2004
27. New G., Moses J.W., Roubin G.S., Leon M.B., Colombo A., Iyer S.S., et al. Estrogen-eluting, phosphorylcholine-coated stent implantation is associated with reduced neointimal formation but no delay in vascular repair in a porcine coronary model. Catheter Cardiovasc Interv 57 (2002) 266-271
28. Chandrasekar B., and Tanguay J.F. Local delivery of 17-beta-estradiol decreases neointimal hyperplasia after coronary angioplasty in a porcine model. J Am Coll Cardiol 36 (2000) 1972-1978
29. Chandrasekar B., Nattel S., and Tanguay J.F. Coronary artery endothelial protection after local delivery of 17beta-estradiol during balloon angioplasty in a porcine model: a potential new pharmacologic approach to improve endothelial function. J Am Coll Cardiol 38 (2001) 1570-1576
30. Abizaid A., Albertal M., Costa M.A., Abizaid A.S., Staico R., Feres F., et al. First human experience with the 17-beta-estradiol-eluting stent: the Estrogen And Stents To Eliminate Restenosis (EASTER) trial. J Am Coll Cardiol 43 (2004) 1118-1121
31. Li L., Haynes M.P., and Bender J.R. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc Natl Acad Sci U S A 100 (2003) 4807-4812
32. Pendaries C., Darblade B., Rochaix P., Krust A., Chambon P., Korach K.S., et al. The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice. Proc Natl Acad Sci U S A 99 (2002) 2205-2210
33. Giguere V. To ERR in the estrogen pathway. Trends Endocrinol Metab 13 (2002) 220-225
34. Lund T.D., Rovis T., Chung W.C., and Handa R.J. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology 146 (2005) 797-807