PAR-2 activating peptide-induced stimulation of pregnant rat myometrium contractile activity partly involves the other membrane receptors

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 130, Issue 1, 2007, Pages 51-59

  Freerksen, Nele ^b   Betancourt, Ancizar ^a   Maul, Holger ^c   Wentz, Melissa ^a   Orise, Phyllis ^a   Günter, Hans Heinrich ^b   Sohn, Christof ^b,c   Vedernikov, Yuri ^a   Saade, George ^a   Garfield, Robert ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Membrane chemoceptors; Myometrium; Proteinase activated receptor 2; Proteinase activated receptor 2 activating peptide SLIGRL; Uterine contractility

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ANTIHISTAMINIC AGENT; ATROPINE; ESTRADIOL; HISTAMINE H1 RECEPTOR; IBUPROFEN; KETANSERIN; KETOTIFEN; LIQUID NITROGEN; MEMBRANE RECEPTOR; MESSENGER RNA; MUSCARINIC RECEPTOR BLOCKING AGENT; PEPTIDE; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE RECEPTOR; WEB 2170BS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; MUSCLE EXCITATION; MUSCLE ISOMETRIC CONTRACTION; MYOMETRIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY; UTERUS CONTRACTILITY;

EID: 33845513943     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2005.11.025     Document Type: Article

References (40)

1. Vu T.K., Hung D.T., Wheaton V.I., and Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64 (1991) 1057-1068
2. Hollenberg M.D., Laniyonu A.A., Saifeddine M., and Moore G.J. Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: evidence for receptor subtypes. Mol Pharmacol 43 (1993) 921-930
3. Al-Ani B., Saifeddine M., and Hollenberg M.D. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 73 (1995) 1203-1207
4. Lerner D.J., Chen M., Tram T., and Coughlin S.R. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem 271 (1996) 13943-13947
5. Bohm S.K., McConalogue K., Kong W., and Bunnett N.W. Proteinase-activated receptors: new function for old enzyme. News Physiol Sci 13 (1998) 231-240
6. Cocks T.M., and Moffatt J.D. Protease-activated receptors: sentries for inflammation?. Trends Pharmacol Sci 21 (2000) 103-108
7. Bohm S., Kong W., Bromme D., et al. Molecular cloning, expression and potential functions of the human proteinase activated receptor-2. Biochem J 314 (1996) 1009-1016
8. Bohm S.K., Khitin L.M., Grady E.F., Aponte G., Payan D.G., and Bunnett N.W. Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 271 (1996) 22003-220016
9. Kong W., McConalogue K., Khitin L.M., et al. Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2. Proc Natl Acad Sci USA 94 (1997) 8884-8889
10. Nystedt S., Emilsson K., Wahlestedt C., and Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 91 (1994) 9208-9212
11. Nystedt S., Larsson A.K., Aberg H., and Sundelin J. The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression. J Biol Chem 270 (1995) 5950-5955
12. Santulli R.J., Derian C.K., Darrow A.L., et al. Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc Natl Acad Sci USA 92 (1995) 9151-9155
13. Macfarlane S.R., Seatter M.J., Kanke T., Hunter G.D., and Plevin R. Proteinase-activated receptors. Pharmacol Rev 53 (2001) 245-282
14. Cottrel G.S., Amadesi S., Schmidlin F., and Bunnett N. Protease-activated receptor 2: activation, signaling and function. Biochem Soc Transact 1 (2003) 1191-1197
15. Hirano K., and Kanaide H. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 10 (2003) 211-225
16. Ossovskaya V.S., and Bunnett N.W. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84 (2004) 579-621
17. Kawabata A. Gastrointestinal functions of proteinase-activated receptors. Life Sci 74 (2003) 247-254
18. Kawabata A., Kubo S., Ishiki T., et al. Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity. J Pharmacol Exp Ther 311 (2004) 402-410
19. Uszynski M., and Rutkowska L. Oxytocic action of thrombin on the rat uterus in vitro. Ginekol Pol 46 7 (1975 Jul) 783-786
20. Orce G., Castillo G., and Esteban S. Oxytocic effect of trypsin on the isolated rat uterus. Hypertension 23 (1994) 1250-1255
21. Katz J., Trol W., Levy M., Filkins K., Russo J., and Levitz M. Estrogen-dependent trypsin-like activity in the rat uterus. Localization of activity in the 12,000 g pellet and nucleus. Arch Biochem Biophys 173 (1976) 347-354
22. Whalley E.T., and Riley A.J. The effect of aprotinin on luteolytic and uterine contractile mechanisms in the pregnant rat at term. J Reprod Fertil 55 (1979) 377-384
23. Chao J., Buse J., Shimamoto K., and Margolis H.S. Kallikrein-induced uterine contraction independent of kinin formation. Proc Natl Acad Sci USA 78 (1981) 6154-6157
24. Orce G.G., Carretero O.A., Scicli G., and Sciclia G. Kinins contribute to contractile effects of rat glandular kallikrein on the isolated rat uterus. J Pharmacol Exp Ther 249 (1989) 470-475
25. Kanayama N., El Marandy E., Halim A., et al. Urinary trypsin inhibitor prevents uterine muscle contraction by inhibition of Ca++ influx. Am J Obstet Gynecol 173 (1995) 192-198
26. Elovitz M., Saunders T., Ascher-Landsberg J., and Phillippe M. Effects of thrombin on myometrial contractions, in vitro and in vivo. Am J Obstet Gynecol 183 (2000) 799-804
27. Elovitz M., Ascher-Landsberg J., Saunders T., and Phillippe M. Thrombin, the mechanisms underlying its stimulatory effects on myometrial smooth muscle. Am J Obstet Gynecol 183 (2000) 674-681
28. Shintani Y., Hirano K., Nishimura J., Nakano H., and Kanaide H. Enhanced contractile response to thrombin in the pregnant rat myometrium. Br J Pharmacol 131 (2000) 1619-1628
29. Vergnolle N. The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors. Can J Gastroenterol 17 10 (2003) 589-592
30. Dong Y., Gangula P., Fang L., and Yallampalli C. Differential expression of cyclooxygenase-1 and -2 proteins in rat uterus and cervix during the estrous cycle, pregnancy, labor and in myometrial cells. Prostaglandins 52 (1996) 13-34
31. Shintani Y., Hirano K., Nakayama T., Nishimura J., Nakano H., and Kanaide H. Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptor. Br J Pharmacol 133 (2001) 1276-1285
32. Chien E.K., Sweet L., Phillippe M., et al. Protease-activated receptor isoform expression in pregnant and non-pregnant rat myometrial tissue. J Soc Gynecol Investig 10 (2003) 460-468
33. Xu W.F., Andersen H., Whitmore T.E., et al. Cloning and characterization of human protease-activated receptor. Proc Natl Acad Sci USA 95 (1998) 6642-6646
34. O'Brien P.J., Koi H., Parry S., et al. Thrombin receptors and protease-activated receptor-2 in human placentation. Receptor activation mediates extravillous throphoblast invasion in vitro. Am J Pathol 163 (2003) 1245-1254
35. Maul H., Byautiene E., Vedernikov Y.P., Garfield R.E., and Saade G.R. Proteinase-activated receptor-2 activation induces uterine contractility in term pregnant rats that is not dependent on mast cell activation and cyclo-oxygenase products. Am J Obstet Gynecol 188 (2003) 1498-1503
36. Ali M., Buhimschi I., Chwalisz K., and Garfield R.E. Changes in expression of the nitric oxide synthase isoforms in rat uterus and cervix during pregnancy and parturition. Mol Hum Reprod 3 (1997) 995-1003
37. Chi L., Li Y., Stehno-Bittel L., et al. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha. J Interferon Cytokine Res 21 (2001) 231-240
38. Rudolph M.I., Bardisa L., Cruz M.A., and Reinicke K. Mast cells mediators evoke contractility and potentiate each other in mouse uterine horns. Gen Pharmacol 23 5 (1992) 833-836
39. Garfield R.E., Byautiene E., Vedernikov Y.P., Marshall J.S., and Romero R. Endogenous mast cell degranulation modulates cervical contractility in the guinea pig. Am J Obstet Gynecol 186 3 (2002) 438-445
40. Rickard A., Portell C., Kell P.J., Vinson S.M., and Mchowat J. Protease activated receptor stimulation activates a calcium-independent phospholipase A2 in bladder microvascular endothelial cells. Am J Physiol Renal Physiol 288 4 (2005) F714-F721