Development of a culture sub-population induction model: Signaling pathways synergy and taxanes production by Taxus canadensis

Biotechnology Progress

Volumn 22, Issue 6, 2006, Pages 1671-1682

  Senger, Ryan S ^a   Phisalaphong, Muenduen ^b   Karim, M Nazmul ^a   Linden, James C ^c  

^a Department of Electrical and Computer Engineering   (United States)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c Engineering Research Center and Hydraulics Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLENE; GENES; GENETIC ALGORITHMS; HORMONES; OPTIMIZATION; PRINCIPAL COMPONENT ANALYSIS;

CELLULAR INDUCTION; EXTRACELLULAR TAXANES; SIGNALING PATHWAYS;

CELL CULTURE;

ACETIC ACID DERIVATIVE; CYCLOPENTANE DERIVATIVE; ETHYLENE; ETHYLENE DERIVATIVE; JASMONIC ACID METHYL ESTER; TAXOID;

ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; COMPUTER SIMULATION; CULTURE TECHNIQUE; DOSE RESPONSE; DRUG EFFECT; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TAXUS;

ACETIC ACIDS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COMPUTER SIMULATION; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENES; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TAXOIDS; TAXUS;

TAXUS; TAXUS CANADENSIS;

EID: 33845508401     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0602552     Document Type: Article

References (66)

1. deFuria, M. D.; Paclitaxel (Taxol(R)). A new natural product with major anticancer activity. Phytomedicine 1997, 4 (3), 273-282.
2. Huizing, M. T.; Misser, V. H.; Pieters, R. C.; ten Bokkel Huinink, W. W.; Veenhof, C. H.; Vermorken, J. B.; Pinedo, H. M.; Beijnen, J. H. Taxanes: a new class of antitumor agents. Cancer Invest. 1995, 13 (4), 381-404.
3. Zhong, J. J. Plant cell culture for production of paclitaxel and other taxanes. J. Biosci. Bioeng. 2002, 94 (6), 591-599.
4. Gueritte, F. General and recent aspects of the chemistry and structure-activity relationships of taxoids. Curr. Pharm. Des. 2001, 7 (13), 1229-1249.
5. Ketchum, R. E.; Gibson, D. M.; Croteau, R. B.; Shuler, M. L. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol. Bioeng. 1999, 62 (1), 97-105.
6. Linden, J. C.; Phisalaphong, M. Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis. Plant Sci. 2000, 158 (1-2), 41-51.
7. Luo, J.; He, G. Y. Optimization of elicitors and precursors for paclitaxel production in cell suspension culture of Taxus chinensis in the presence of nutrient feeding. Process Biochem. 2004, 39 (9), 1073-1079.
8. Mirjalili, N.; Linden, J. C. Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: Ethylene interaction and induction models. Biotechnol. Prog. 1996, 12 (1), 110-118.
9. Mirjalili, N.; Linden, J. C. Gas-phase composition effects on suspension-cultures of Taxus cuspidata. Biotechnol. Bioeng. 1995, 48 (2), 123-132.
10. Kim, S.; Choi, H.; Kim, J.; Lee, H.; Hong, S. Effect of osmotic pressure on paclitaxel production in suspension cell cultures of Taxus chinensis. Enzyme Microb. Technol. 2001, 28 (2-3), 202-209.
11. Sun, X.; Linden, J. C. Shear stress effects on plant cell suspension cultures in a rotating wall vessel bioreactor. J. Ind. Microbiol. Biotechnol. 1999, 22 (1), 44-47.
12. Choi, H. K.; Kim, S. I.; Son, J. S.; Hong, S. S.; Lee, H. S.; Lee, H. J. Enhancement of paclitaxel production by temperature shift in suspension culture of Taxus chinensis. Enzyme. Microb. Technol. 2000, 27 (8), 593-598.
13. Jaziri, M.; Zhiri, A.; Guo, Y. W.; Dupont, J. P.; Shimomura, K.; Hamada, H.; Vanhaelen, M.; Homes, J. Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: A literature survey. Plant Cell, Tissue Organ Cult. 1996, 46 (1), 59-75.
14. Kim, B. J.; Gibson, D. M.; Shuler, M. L. Relationship of viability and apoptosis to taxol production in Taxus sp. suspension cultures elicited with methyl jasmonate. Biotechnol. Prog. 2005, 21 (3), 700-707.
15. Phisalaphong, M.; Linden, J. C. Kinetic studies of paclitaxel production by Taxus canadensis cultures in batch and semicontinuous with total cell recycle. Biotechnol. Prog. 1999, 15 (6), 1072-1077.
16. Roberts, S. C.; Naill, M.; Gibson, D. M.; Shuler, M. L. A simple method for enhancing paclitaxel release from Taxus canadensis cell suspension cultures utilizing cell wall digesting enzymes. Plant Cell Rep. 2003, 21 (12), 1217-1220.
17. Pozo, M. J.; van Loon, L. C.; Pieterse, C. M. J. Jasmonates: signals in plant-microbe interactions. J. Plant Growth Regul. 2005, 23 (3), 211-222.
18. Howe, G. A. Jasmonates as signals in the wound response. J. Plant Growth Regul. 2004, 23 (3), 223-237.
19. O'Donnell, P. J.; Calvert, C.; Atzorn, R.; Wasternack, C.; Leyser, H. M. O.; Bowles, D. J. Ethylene as a signal mediating the wound response of tomato plants. Science 1996, 274 (5294), 1914-1917.
20. Surplus, S. L.; Jordan, B. R.; Murphy, A. M.; Carr, J. P.; Thomas, B.; Mackerness, S. A. H. Ultraviolet-B-induced responses in Arabidopsis thaliana: role of salicylic acid and reactive oxygen species in the regulation of transcripts encoding photosynthetic and acidic pathogenesis-related proteins. Plant Cell Environ. 1998, 21 (7), 685-694.
21. Wang, K. L.; Li, H.; Ecker, J. R. Ethylene biosynthesis and signaling networks. Plant Cell 2002, 14 Suppl, S131-S151.
22. Reymond, P.; Farmer, E. E. Jasmonate and salicylate as global signals for defense gene expression. Curr. Opin. Plant Biol. 1998, 1 (5), 404-411.
23. Rojo, E.; Solano, R.; Sanchez-Serrano, J. J. Interactions between signaling compounds involved in plant defense. J. Plant Growth Regul. 2003, 22 (1), 82-98.
24. Yuan, Y. J.; Li, C.; Hu, Z. D.; Wu, J. C. A double oxidative burst for taxol production in suspension cultures of Taxus chinensis var. mairei induced by oligosaccharide from Fusarium oxysprum. Enzyme Microb. Technol. 2002, 30, 774-778.
25. Yuan, Y. J.; Li, C.; Hu, Z. D.; Wu, J. C.; Zeng, A. P. Fungal elicitor-induced cell apoptosis in suspension cultures of Taxus chinensis var. mairei for taxol production. Process Biochem. 2002, 38, 193-198.
26. Wu, J.; Wang, C.; Mei, X. Stimulation of taxol production and excretion in Taxus spp. cell cultures by rare earth chemical lanthanum. J. Biotechnol. 2001, 85 (1), 67-73.
27. Yuan, Y. J.; Hu, G. W.; Wang, C. G.; Jing, Y.; Zhou, Y. Q.; Shen, P. W. Effect of rare earth compounds on the growth, taxol biosynthesis and release in Taxus cuspidata cell culture. J. Chin. Rare Earth Soc. 1998, 16, 56-60.
28. Cheong, J. J.; Choi, Y. D. Methyl jasmonate as a vital substance in plants. Trends Genet. 2003, 19 (7), 409-413.
29. Sasaki, Y.; Asamizu, E.; Shibata, D.; Nakamura, Y.; Kaneko, T.; Awai, K.; Amagai, M.; Kuwata, C.; Tsugane, T.; Masuda, T.; Shimada, H.; Takamiya, K.; Ohta, H.; Tabata, S. Monitoring of methyl jasmonate-responsive genes in Arabidopsis by cDNA macroarray: self-activation of jasmonic acid biosynthesis and crosstalk with other phytohormone signaling pathways. DNA Res. 2001, 8 (4), 153-161.
30. Pieterse, C. M.; van Loon, L. C. Salicylic acid-independent plant defence pathways. Trends Plant Sci. 1999, 4 (2), 52-58.
31. Lorenzo, O.; Piqueras, R.; Sanchez-Serrano, J. J.; Solano, R. ETHYLENE RESPONSE FACTOR1 integrates signals from ethylene and jasmonate pathways in plant defense. Plant Cell 2003, 15 (1), 165-178.
32. Schenk, P. M.; Kazan, K.; Wilson, I.; Anderson, J. P.; Richmond, T.; Somerville, S. C.; Manners, J. M. Coordinated plant defense responses in Arabidopsis revealed by microarray analysis. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (21), 11655-11660.
33. Brader, G.; Tas, E.; Palva, E. T. Jasmonate-dependent induction of indole glucosinolates in Arabidopsis by culture filtrates of the nonspecific pathogen Erwinia carotovora. Plant Physiol. 2001, 126 (2), 849-860.
34. Chao, Q.; Rothenberg, M.; Solano, R.; Roman, G.; Terzaghi, W.; Ecker, J. R. Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins. Cell 1997, 89 (7), 1133-1144.
35. Solano, R.; Stepanova, A.; Chao, Q.; Ecker, J. R. Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1. Genes Dev. 1998, 12 (23), 3703-3714.
36. Ohme-Takagi, M.; Shinshi, H. Structure and expression of a tobacco beta-1,3-glucanase gene. Plant Mol. Biol. 1990, 15 (6), 941-946.
37. Ohme-Takagi, M.; Shinshi, H. Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 1995, 7 (2), 173-182.
38. Penninckx, I. A.; Thomma, B. P.; Buchala, A.; Metraux, J. P.; Broekaert, W. F. Concomitant activation of jasmonate and ethylene response pathways is required for induction of a plant defensin gene in Arabidopsis. Plant Cell 1998, 10 (12), 2103-2113.
39. Brown, R. L.; Kazan, K.; McGrath, K. C.; Maclean, D. J.; Manners, J. M. A role for the GCC-box in jasmonate-mediated activation of the PDF1.2 gene of Arabidopsis. Plant Physiol. 2003, 132 (2), 1020-1032.
40. Rao, M. V.; Davis, K. R. Ozone-induced cell death occurs via two distinct mechanisms in Arabidopsis: the role of salicylic acid. Plant J. 1999, 17 (6), 603-614.
41. Rojo, E.; Leon, J.; Sanchez-Serrano, J. J. Cross-talk between wound signalling pathways determines local versus systemic gene expression in Arabidopsis thaliana. Plant J. 1999, 20 (2), 135-142.
42. Ryals, J.; Ukness, S.; Ward, E. Systemic acquired-resistance. Plant Physiol. 1994, 104, 1109-1112.
43. Frye, C. A.; Tang, D.; Innes, R. W. Negative regulation of defense responses in plants by a conserved MAPKK kinase. Proc. Natl. Acad. Sci. U.S.A. 2001, 98 (1), 373-378.
44. Doares, S. H.; Narvaezvasquez, J.; Conconi, A.; Ryan, C. A. Salicylic-acid inhibits synthesis of proteinase-inhibitors in tomato leaves induced by systemin and jasmonic acid. Plant Physiol. 1995, 108 (4), 1741-1746.
45. Harms, K.; Ramirez, I. I.; Pena-Cortes, H. Inhibition of wound-induced accumulation of allene oxide synthase transcripts in flax leaves by aspirin and salicylic acid. Plant Physiol. 1998, 118 (3), 1057-1065.
46. Pena-Cortes, H.; Albrecht, T.; Prat, S.; Weiler, E. W.; Willmitzer, L. Aspirin prevents wound-induced gene-expression in tomato leaves by blocking jasmonic acid biosynthesis. Planta 1993, 191 (1), 123-128.
47. Yanpaisan, W.; King, N. J.; Doran, P. M. Analysis of cell cycle activity and population dynamics in heterogeneous plant cell suspensions using flow cytometry. Biotechnol. Bioeng. 1998, 58 (5), 515-528.
48. Yanpaisan, W.; King, N. J.; Doran, P. M. Flow cytometry of plant cells with applications in large-scale bioprocessing. Biotechnol. Adv. 1999, 17 (1), 3-27.
49. Naill, M. C.; Roberts, S. C. Preparation of single cells from aggregated Taxus suspension cultures for population analysis. Biotechnol. Bioeng. 2004, 86 (7), 817-826.
50. Naill, M. C.; Roberts, S. C. Culture of isolated single cells from Taxus suspensions for the propagation of superior cell populations. Biotechnol. Lett. 2005, 27 (21), 1725-1730.
51. Naill, M. C.; Roberts, S. C. Flow cytometric analysis of protein content in Taxus protoplasts and single cells as compared to aggregated suspension cultures. Plant Cell Rep. 2005, 23 (8), 528-533.
52. Naill, M. C.; Roberts, S. C. Flow cytometric identification of Paclitaxel-accumulating subpopulations. Biotechnol. Prog. 2005, 21 (3), 978-983.
53. Naill, M. C.; Roberts, S. C. Cell cycle analysis of Taxus suspension cultures at the single cell level as an indicator of culture heterogeneity. Biotechnol. Bioeng. 2005, 90 (4), 491-500.
54. Ketchum, R. E.; Gibson, D. M. Paclitaxel production in suspension cultures of Taxus. Plant Cell Tiss. Org. Cult. 1996, 46 (1), 9-16.
55. Phisalaphong, M. Metabolic manipulation of Taxus canadensis for Taxol production. Colorado State University, Fort Collins, 1999.
56. Karim, M. N.; Hodge, D.; Simon, L. Data-based modeling and analysis of bioprocesses: some real experiences. Biotechnol. Prog. 2003, 19 (5), 1591-1605.
57. Wise, B.; Gallagher, N. PLS toolbox 2.1. Eigenvector Research: Manson, WA, 2000.
58. Holland, J. H. Adaptation in Natural and Artificial Systems; University of Michigan Press: Ann Arbor, 1975.
59. Herrera, F.; Lozano, M.; Verdegay, J. L. Tackling real-coded genetic algorithms: Operators and tools for behavioural analysis. Artif. Intell. Rev. 1998, 12 (4), 265-319.
60. Goldberg, D. E. Genetic Algorithms in Search, Optimization and Machine Learning; Adison-Wesley: New York, 1989.
61. Michalewicz, Z. Genetic Algorithms + Data Structures = Evolution Programs; Springer-Verlag: New York, 1992.
62. Eshelman, L. J.; Schaffer, J. D. Real-coded genetic algorithms and interval-schemata. In Foundation of Genetic Algorithms 2; Whitley, L. D., Ed.; Morgan Kaufmann: San Mateo, 1993.
63. Walker, K.; Croteau, R. Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (2), 583-587.
64. Jennewein, S.; Wildung, M. R.; Chau, M.; Walker, K.; Croteau, R. Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (24), 9149-9154.
65. Walker, K.; Fujisaki, S.; Long, R.; Croteau, R. Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (20), 12715-12720.
66. Walker, K.; Long, R.; Croteau, R. The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (14), 9166-9171.