A novel 24-base pair deletion in the coding region of CCR5 in an African population [1]

AIDS

Volumn 21, Issue 1, 2007, Pages 111-113

  Masquelier, Cecile ^a   Servais, Jean Yeves ^a   Rusanganwa, Emmanual ^b   Roman, Francois ^a   Havuga, Emmanuel ^b,c   Servais, Jean ^a   Tuyizere, Samuel ^b   Omes, Christine ^b,c   Karasi, Jean Claude ^b,c   Coruteille, Olivier ^b,c   Karita, Etienne ^d   Allen, Susan ^d   Schmit, Jean Claude ^a   Arendt, Vic ^a,b  

^a Retrovirology Laboratory Luxembourg   (Luxembourg)

^b National Reference Laboratory   (Rwanda)

^c Lux Development   (Rwanda)

^d Project San Francisco   (Rwanda)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ETHNOLOGY; GENE DELETION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LETTER; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS TRANSMISSION;

EID: 33845496758     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000254687.86122.fa     Document Type: Letter

References (12)

1. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381:667-673.
2. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996; 382:722-725.
3. Martin MP, Carrington M. The role of human genetics in HIV-1 infection. In: Chemokine receptors and AIDS. Edited by O'Brien T. New York: Marcel Dekker Inc; 2002. pp. 133-162.
4. Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, et al. HIV-1-resistance phenotype conferred by combination of two separate inherited mutation of CCR5 gene. Lancet 1998; 351:14-18.
5. Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet 1997; 16:100-103.
6. Libert F, Cochaux P, Beckman G, Samson M, Aksenova M, Cao A, et al. The ΔCCR5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in northeastern Europe. Hum Mol Genet 1998; 7:399-406.
7. Govaerts C, Blanpain C, Deupi X, Ballet S, Ballesteros JA, Wodak SJ, et al. The TXP motif in the second transmembrane helix of CCR5. J Biol Chem 2001; 276:13217-13225.
8. Govaerts C, Bondue A, Springael JY, Olivella M, Deupi X, Le Poul E, et al. Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3. J Biol Chem 2003; 278:1892-1903.
9. Atchison RE, Gosling J, Monteclaro FS, Franci C, Digilio L, Charo IF, et al. Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines. Science 1996; 274:1924-1926.
10. Bieniasz PD, Fridell RA, Aramori I, Ferguson SS, Caron MG, Cullen BR. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J 1997; 16:2599-2609.
11. Rucker J, Samson M, Doranz BJ, Libert F, Berson JF, Yi Y, et al. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell 1996; 87:437-446.
12. Chen Z, Kwon D, Jin Z, Monard S, Telfer P, Jones MS, et al. Natural infection of a homozygous Δ24 CCR5 red-capped mangabey with an R2b-tropic simian immunodeficiency virus. J Exp Med 1998; 188:2057-2065.