Low-level dietary deoxynivalenol and acute exercise stress result in immunotoxicity in BALB/c mice

Journal of Immunotoxicology

Volumn 3, Issue 4, 2006, Pages 173-178

  Landgren, C A ^a   Hendrich, S ^a   Kohut, M L ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Acute exercise stress; Corticosterone; Deoxynivalenol; Mice; Splenocyte

Indexed keywords

CONCANAVALIN A; CORTICOSTERONE; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE ANTIGEN; VOMITOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CELL STIMULATION; CELL SUSPENSION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CYTOKINE RELEASE; DIETARY INTAKE; ENZYME IMMUNOASSAY; ERYTHROCYTE; FATIGUE; HEMOLYSIS; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOTOXICITY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PHYSICAL STRESS; PRIORITY JOURNAL; SPLEEN CELL; TREADMILL EXERCISE;

ANIMALIA; OVIS ARIES;

EID: 33845487709     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910600979978     Document Type: Article

References (28)

1. Abbas, A., Murphy, K. M., and Sher, A. 1996. Functional diversity of helper T-lymphocytes. Nature 383:787-793.
2. Agnello, D., Lankford, C. S., Bream, J., Morinobu, A., Gadina, M., O'Shea, J. J., and Frucht, D. M. 2003. Cytokines and transcription factors that regulate T-helper cell differentiation: New players and new insights. J. Clin. Immunol. 23:147-161.
3. Arnold, D. L., McGuire, P. F., Nera, E. A., Karpinski, K. F., Bickis, M. G., Zawidzka, Z. Z., Fernie, S., and Vesonder R. F. 1986. The toxicity of orally-administered deoxynivalenol (vomitoxin) in rats and mice. Food Chem. Toxicol. 24:935-941.
4. Bhat, R. V., Beedu, S. R., Ramakrishna, Y., and Munshi, K. L. 1989. Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir Valley, India. Lancet (8628):35-37.
5. Cunningham, A. J., and Szenberg, A. 1968. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology 14:599-600.
6. Elenkov, I. J., and Chrousos, G. P. 2002. Stress hormones, pro-inflammatory and anti-inflammatory cytokines, and autoimmunity. Ann. N.Y. Acad. Sci. 966:290-303.
7. 1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem. Toxicol. 24:213-219.
8. 1 mouse: Dose response and male predilection. Toxicology 92:245-260.
9. Handa, K., Sukuki, R., Matsui, H., Shimizu, Y., and Kumagai, K. 1983. Natural killer (NK) cells as responders to interleukin-2 (IL-2) II. IL 2-induced interferon-γ Production. J. Immunol. 130:988-992.
10. Hoffman-Goetz, L., Thorne, R. J., and Houston, M. E. 1988. Splenic immune responses following treadmill exercise in mice. Can. J. Physiol. Pharmacol. 66:1415-1419.
11. Hoffman-Goetz, L., Thorne, R., Simpson, J. A., and Arumugam, Y. 1989. Exercise stress alters murine lymphocyte subset distribution in spleen, lymph nodes, and thymus. Clin. Exp. Immunol. 76:307-310.
12. Islam, Z., Moon, Y. S., Zhou, H. R., King, L. E., Fraker, P. J., and Pestka, J. J. 2002. Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. Toxicol. Appl. Pharm. 180:43-55.
13. Li, F. Q., Li, Y. W., Luo, X. Y., and Yoshizawa, T. 2002. Fusarium toxins in wheat from an area in Henan province, PR China, with a previous human Red Mould intoxication episode. Food Addit. Contam. 19:163-167.
14. Madden, K. S., Sanders, V. M., and Felten, D. L. 1995. Catecholamine influences and sympathetic neural modulation of immune responsiveness. Ann. Rev. Pharmacol. Toxicol. 35:417-448.
15. Meky, F. A., Turner, P. C., Ashcroft, A. E., Miller, J. D., Qiao, Y. L., Roth, M. J., and Wild, C. P. 2003. Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem. Toxicol. 41:265-273.
16. Miller, K., and Atkinson, H. A. 1986. The in vitro effects of trichothecenes on the immune system. Food Chem. Toxicol. 24:545-549.
17. + T-cells. Toxicology 104:187-202.
18. Pedersen, B. K., Bruunsgaard, H., Klokker, M., Kappel, M., MacLean, D. A., Nielsen, H. B., Rohde, T., Ullum, H., and Zacho, M. 1997. Exercise-induced immunomodulation - Possible roles of neuroendocrine and metabolic factors. Int. J. Sports Med. 18:S2-S7.
19. Pedersen, B. K., and Hoffman-Goetz, L. 2000. Exercise and the immune system: Regulation, integration, and adaptation. Physiol. Rev. 80:1055-1081.
20. Pestka, J. J., and Smolinski, A. T. 2005. Deoxynivalenol: Toxicology and potential effects on humans. J. Toxicol. Environ. Health, Part B 8:39-69.
21. Randall Simpson, J. A., Hoffman-Goetz, L., Thorne, R., and Y. Arumugam, Y. 1989. Exercise stress alters the percentage of splenic lymphocyte subsets in response to mitogen but not in response to interleukin-1. Brain Behav. Immun. 3:119-128.
22. Reeves, P. G., Nielsen, F. H., and Fahey, G. C., Jr. 1993. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J. Nutr. 123:1939-1951.
23. Robbana-Barnat, S., Loridon-Rosa, B., Cohen, H., Lafarge-Frayssinet, C., Neish, G. A., and Frayssinet, C. 1987. Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice. Food Addit. Contam. 4:49-55.
24. Robbana-Barnat, S., Lafarge-Frayssinet, C., Cohen, H., Neish, G. A., and Frayssinet, C. 1988. Immunosuppressive properties of deoxynivalenol. Toxicology 48:155-166.
25. Rotter, B. A., Prelusky, D. B., and Pestka, J. J. 1996. Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 48:1-34.
26. Tryphonas, H., Iverson, F., So, Y., Nera, E. A., McGuire, P. F., O'Grady, L., Clayson, D. B., and Scott, P. M. 1986. Effects of deoxynivalenol (vomitoxin) on the humoral and cellular immunity of mice. Toxicol. Lett. 30:137-150.
27. Warner, R. L., Brooks, K., and Pestka, J. J. 1994. In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion. Food Chem. Toxicol. 32:617-625.
28. Zhou, H. R., Yan, D., and Pestka, J. J. 1998. Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (deoxynivalenol): Differential toxin-induced hyporesponsiveness and recovery. Toxicol. Appl. Pharmacol. 151:347-358.