No association of the CYP3A5* I allele with blood pressure and left ventricular mass and geometry: The KORA/MONICA Augsburg echocardiographic substudy

Clinical Science

Volumn 111, Issue 6, 2006, Pages 365-372

  Lieb, Wolfgang ^a   Bolbrinker, Juliane ^b   Döring, Angela ^c   Hense, Hans Werner ^d   Erdmann, Jeanette ^a   Schunkert, Heribert ^a   Kreutz, Reinhold ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Blood pressure; Cytochrome P450 3A (CYP3A); Echocardiography; Hypertension; Left ventricular mass; Pharmacogenetics

Indexed keywords

CYTOCHROME P450 3A5; CYP3A5 PROTEIN, HUMAN; CYTOCHROME P450;

ADULT; AGED; ALLELE; ARTICLE; BLOOD PRESSURE; BODY MASS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; GENE FREQUENCY; GENOTYPE; HEALTH SURVEY; HEART LEFT VENTRICLE MASS; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; GENETIC POLYMORPHISM; GENETICS; GLOMERULUS FILTRATION RATE; HEART LEFT VENTRICLE HYPERTROPHY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AGED; BLOOD PRESSURE; CYTOCHROME P-450 ENZYME SYSTEM; ECHOCARDIOGRAPHY; FEMALE; GENOTYPE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 33845452858     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20060075     Document Type: Article

References (32)

1. Givens, R. C., Lin, Y. S., Dowling, A. L. et al. (2003) CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults. J. Appl. Physiol. 95, 1297-1300
2. Haehner, B. D., Gorski, J. C., Vandenbranden, M. et al. (1996) Bimodal distribution of renal cytochrome P450 3A activity in humans. Mol. Pharmacol. 50, 52-59
3. Wojnowski, L. (2004) Genetics of the variable expression of CYP3A in humans. Ther. Drug Monit. 26, 192-199
4. Schuetz, E. G., Schuetz, J. D., Grogan, W. M. et al. (1992) Expression of cytochrome P450 3A in amphibian, rat, and human kidney. Arch. Biochem. Biophys. 294, 206-214
5. Murray, G. I., McFadyen, M. C., Mitchell, R. T., Cheung, Y. L., Kerr, A. C. and Melvin, W. T. (1999) Cytochrome P450 CYP3A in human renal cell cancer. Br. J. Cancer 79, 1836-1842
6. Morris, D. J., Latif, S. A., Rokaw, M. D., Watlington, C. O. and Johnson, J. P. (1998) A second enzyme protecting mineralocorticoid receptors from glucocorticoid occupancy. Am. J. Physiol. 274, C1245-C1252
7. Wrighton, S. A., Brian, W. R., Sari, M. A. et al. (1990) Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol. Pharmacol. 38, 207-213
8. Watlington, C. O., Kramer, L. B., Schuetz, E. G. et al. (1992) Corticosterone 6β-hydroxylation correlates with blood pressure in spontaneously hypertensive rats. Am. J. Physiol. 262, F927-F931
9. Kreutz, R., Zuurman, M., Kain, S., Bolbrinker, J., de Jong, P. E. and Navis, G. (2005) The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population. Pharmacogenet. Genomics 15, 831-837
10. Kuehl, P., Zhang, J., Lin, Y. et al. (2001) Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat. Genet. 27, 383-391
11. Lin, Y. S., Dowling, A. L., Quigley, S. D. et al. (2002) Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol. Pharmacol. 62, 162-172
12. Ho, H., Pinto, A., Hall, S. D. et al. (2005) Association between the CYP3A5 genotype and blood pressure. Hypertension 45, 294-298
13. Kivisto, K. T., Niemi, M., Schaeffeler, E. et al. (2005) CYP3A5 genotype is associated with diagnosis of hypertension in elderly patients: data from the DEBATE Study. Am. J. Pharmacogenomics 5, 191-195
14. Fromm, M. F., Schmidt, B. M., Pahl, A., Jacobi, J. and Schmieder, R. E. (2005) CYP3A5 genotype is associated with elevated blood pressure. Pharmacogenet. Genomics 15, 737-741
15. Bochud, M., Eap, C. B., Elston, R. C. et al. (2006) Association of CYP3A5 genotypes with blood pressure and renal function in African families. J. Hypertens. 24, 923-929
16. Thompson, E. E., Kuttab-Boulos, H., Witonsky, D., Yang, L., Roe, B. A. and Di, R. A. (2004) CYP3A variation and the evolution of salt-sensitivity variants. Am. J. Hum. Genet. 75, 1059-1069
17. Schmieder, R. E., Messerli, F. H., Garavaglia, G. E. and Nunez, B. D. (1988) Dietary salt intake. A determinant of cardiac involvement in essential hypertension. Circulation 78, 951-956
18. Langenfeld, M. R. and Schmieder, R. E. (1995) Salt and left ventricular hypertrophy: what are the links? J. Hum. Hypertens. 9, 909-916
19. Rothermund, L., Vetter, R., Dieterich, M. et al. (2002) Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension. Circulation 106, 2305-2308
20. Koren, M. J., Mensah, G. A., Blake, J., Laragh, J. H. and Devereux, R. B. (1993) Comparison of left ventricular mass and geometry in black and white patients with essential hypertension. Am. J. Hypertens. 6, 815-823
21. Kannel, W. B. (2000) Risk stratification in hypertension: new insights from the Framingham Study. Am. J. Hypertens. 13, 3S-10S
22. Lorell, B. H. and Carabello, B. A. (2000) Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 102, 470-479
23. du Cailar, G., Ribstein, J. and Mimran, A. (2002) Dietary sodium and target organ damage in essential hypertension. Am. J. Hypertens. 15, 222-229
24. Schunkert, H., Hengstenberg, C., Holmer, S. R. et al. (1999) Lack of association between a polymorphism of the aldosterone synthase gene and left ventricular structure. Circulation 99, 2255-2260
25. Devereux, R. B., Lutas, E. M., Casale, P. N. et al. (1984) Standardization of M-mode echocardiographic left ventricular anatomic measurements. J. Am. Coll. Cardiol. 4, 1222-1230
26. Devereux, R. B., Alonso, D. R., Lutas, E. M. et al. (1986) Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am. J. Cardiol. 57, 450-458
27. Schunkert, H., Hense, H. W., Muscholl, M. et al. (1997) Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass. Heart 77, 24-31
28. Levey, A. S., Coresh, J., Balk, E. et al. (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann. Intern. Med. 139, 137-147
29. Kreutz, R., Zurcher, H., Kain, S., Martus, P., Offermann, G. and Beige, J. (2004) The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients. Pharmacogenetics 14, 665-671
30. Ranade, K., Chang, M. S., Ting, C. T. et al. (2001) High-throughput genotyping with single nucleotide polymorphisms. Genome Res. 11, 1262-1268
31. Smith, G., Stubbins, M. J., Harries, L. W. and Wolf, C. R. (1998) Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica 28, 1129-1165
32. Weinberger, M. H. (1996) Salt sensitivity of blood pressure in humans. Hypertension 27, 481-490