A second enzyme protecting mineralocorticoid receptors from glucocorticoid occupancy

American Journal of Physiology - Cell Physiology

Volumn 274, Issue 5 43-5, 1998, Pages

  Morris, David J ^a   Latif, Syed A ^a   Rokaw, Michael D ^b   Watlington, Charles O ^c   Johnson, John P ^b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Sodium transport; Steroid 6 hydroxylase

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CARBENOXOLONE; CHENODEOXYCHOLIC ACID; CORTICOSTERONE; CYTOCHROME P450; DEHYDROCORTICOSTERONE; GLUCOCORTICOID RECEPTOR; HYDROXYCORTICOSTEROID; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; OXPRENOATE POTASSIUM; OXYGENASE; SODIUM ION; TETRAHYDROPROGESTERONE; TROLEANDOMYCIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SODIUM TRANSPORT; XENOPUS LAEVIS;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A; XENOPUS LAEVIS;

EID: 0031804484     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.274.5.c1245     Document Type: Article

References (44)

1. Armanini, D., I. Karobowiak, J. W. Funder, and W. R. Adam. The mechanism of mineralocorticoid action of carbenoxolone. Endocrinology 111: 1683-1686, 1982.
2. Bastl, C. P., and J. P. Hayslett. The cellular action of aldosterone in target epithelia. Kidney Int. 42: 250-264, 1992.
3. Brem, A. S., K. L. Matheson, T. Conca, and D. J. Morris. Effect of carbenoxolone on glucocorticoid metabolism and Na transport in toad bladder. Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26): F700-F704, 1989.
4. Brem, A. S., K. L. Matheson, S. A. Latif, and D. J. Morris. Activity of 11β-hydroxysteroid dehydrogenase in toad bladder: effects of 11-dehydrocorticosterone. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F854-F858, 1993.
5. Bush, I. E., S. A. Hunter, and R. A. Meigs. Metabolism of 11-oxygenated steroids. Biochem. J. 107: 239-257, 1968.
6. Claire, M., B. Mackard, M. Lombes, M. Oblin, J. Bonvalet, and N. Farman. Aldosterone receptors in A6 cells: physicochemical characterization and autoradiographic study. Am. J. Physiol. 257 (Cell. Physiol. 26): C665-C677, 1989.
7. Clore, J., A. Schoolwerth, and C. O. Watlington. When is cortisol a mineralocorticoid? Kidney Int. 42: 1297-1308, 1992.
8. + transport stimulation in A6 cells. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F736-F748, 1988.
9. Edwards, C. R. W., D. Burt, M. A. McIntyre, E. R. DeKloet, P. M. Stewart, L. Brett, W. S. Sutanto, and C. Monder. Localization of 11β-hydroxysteroid dehydrogenase: tissue specific protector of the mineralocorticoid receptor. Lancet 2: 986-989, 1988.
10. Funder, J. W. Corticosteroid receptors and the central nervous system. J. Steroid Biochem. Mol. Biol. 49: 381-384, 1994.
11. Funder, J. W., P. T. Pearce, R. Smith, and A. L. Smith. Mineralocorticoid action: target tissue specificity is enzyme not receptor mediated. Science 242: 583-585, 1988.
12. Gaeggeler, H. P., C. R. W. Edwards, and B. C. Rossier. Steroid metabolism determines mineralocorticoid specificity in toad bladder. Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26): F690-F695, 1989.
13. Ghosh, S., M. Grogan, A. Basu, and C. Watlington. Renal corticosterone 6β-hydroxylase in the spontaneously hypertensive rat. Biochim. Biophys. Acta 1182: 152-156, 1993.
14. + transport. Endocrinology 116: 1189-1194, 1985.
15. Grogan, W. M., V. M. Philips, E. G. Schuetz, P. S. Guzelian, and C. O. Watlington. Corticosterone 6β-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450. Am. J. Physiol. 258 (Cell Physiol. 27): C480-C488, 1990.
16. Johnson, J. P. Cellular mechanisms of action of mineralocorticoid hormones. Pharmacol. Ther. 53: 1-29, 1992.
17. Kenouch, S., N. Alfaidy, J. P. Bonvalet, and N. Farman. Expression of 11β-OHSD along the nephron of mammals and humans. Steroids 59: 100-104, 1994.
18. Kirk, D. N., P. J. Burke, H. C. Toms, S. A. Latif, and D. J. Morris. Substituted steroids. Part 15. 6β-Hydroxylation of aldosterone by rat liver. Steroids 54: 169-184, 1989.
19. Krozowski, Z. S., and J. W. Funder. Renal mineralocorticoid receptors and hippocampal corticosteroid binding species have identical intrinsic steroid specificity. Proc. Natl. Acad. Sci. USA 80: 6054-6060, 1983.
20. + retention. Steroids 59: 352-356, 1994.
21. Latif, S. A., M. F. Sheff, C. E. Ribero, and D. J. Morris. Selective inhibition of sheep kidney 11β-hydroxysteroid dehydrogenase isoform 2 activity by 5α-reduced (but not 5β) derivatives of adrenocorticosteroids. Steroids 62: 230-237, 1997.
22. Monder, C., and P. C. White. 11β-Hydroxysteroid dehydrogenase. Vitam. Horm. 47: 187-269, 1993.
23. 6 (toad kidney) cells in culture. Steroids 55: 482-487, 1990.
24. Morris, D. J., and G. W. Souness. The 11β-OHSD inhibitor, carbenoxolone, enhances Na retension by aldosterone and 11-deoxycorticosterone. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F756-F759, 1990.
25. Mune, T., F. M. Rogerson, H. Nikkila, A. K. Agarwal, and P. C. White. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase. Nat. Genet. 10: 394-399, 1995.
26. New, M. I., S. E. Oberfield, R. Carey, F. Grieg, S. Ulick, and L. S. Lavine. A genetic defect in cortisol metabolism as the basis for the syndrome of apparent mineralocorticoid excess syndrome. In: Serono Symposium New York: Academic, 1982, vol. 50, p. 85-101.
27. Oberfield, S. E., L. S. Levine, R. M. Carey, F. Grieg, S. Ulick, and M. I. New. Metabolic and blood pressure responses to hydrocortisone in syndrome of apparent mineralocorticoid excess. J. Clin. Endocrinol. Metab. 56: 332-339, 1983.
28. Pearce, D., and K. R. Yamamoto. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259: 1161-1165, 1993.
29. Perschel, F. H., H. Buhler, and K. Hierholzer. Bile acids and their amidates inhibit 11β-hydroxysteroid dehydrogenase obtained from rat kidney. Pflügers Arch. 418: 538-543, 1991.
30. Rupprecht, R., J. L. Arriza, D. Spengler, J. M. H. M. Reul, R. M. Evans, F. Holsboer, and K. Damm. Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. Mol. Endocrinol. 7: 597-603, 1993.
31. Rupprecht, R., J. M. H. M. Reul, B. Van Steensel, D. Spengler, M. Soder, B. Berning, F. Holsboer, and K. Damm. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur. J. Pharmacol. 274: 145-154, 1993.
32. Rusvai, E., and A. Naray-Fejes-Toth. A new isoform of 11β-hydroxysteroid dehydrogenase in aldosterone target cells J. Biol. Chem. 268: 10717-10720, 1993.
33. Schemtz, E. G., J. O. Schemtz, W. M. Grogan, A. Naray-Fejes-Toth, G. Fejes-Toth, J. Raucy, P. Guzelian, K. Gionela, and C. O. Watlington. Expression of cytochrome P450 A in amphibian, rat and human kidney. Arch. Biochem. Biophys. 294: 206-214, 1992.
34. + transport in A6 cells is mediated via glucocorticoid receptors. Am. J. Physiol. 264 (Cell Physiol. 33): C875-C884, 1993.
35. Sheppard, K. E., and J. W. Funder. Equivalent affinity of aldosterone and corticosterone for type 1 receptors in kidney and hippocampus: direct binding studies. J. Steroid Biochem. 28: 737-742, 1987.
36. Souness, G. W., and D. J. Morris. The antinatriuretic and kaliuretic effects of corticosterone and cortisol following pretreatment with carbenoxolone sodium (a licorice derivative) in the adrenalectomized rat. Endocrinology 124: 1588-1590, 1989.
37. Souness, G. W., and D. J. Morris. 11β-Dehydrocorticosterone in the presence of carbenoxolone is a more potent sodium retainer than its parent steroid corticosterone. Steroids 58: 24-28, 1993.
38. Souness, G. W., and D. J. Morris. The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type 1) antagonist RU28318. Endocrinology 129: 2451-2456, 1993.
39. Trapp, T., R. Rupprecht, M. Castren, J. M. H. M. Reul, and F. Holsboer. Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS. Neuron 13: 1457-1462, 1994.
40. Ulick, S., L. S. Levine, P. Gunczler, G. Zanconato, L. C. Ramirez, W. Rauh, A. Rosler, H. L. Bradlow, and M. New. A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J. Clin. Endocrinol. Metab. 49: 757-764, 1979.
41. Ulick, S., L. C. Ramires, and M. I. New. An abnormality in steroid reductive metabolism in a hypertensive syndrome. J. Clin. Endocrinol. Metab. 44: 799-802, 1977.
42. Verry, F. Transcriptional control of sodium transport in tight epithelia by adrenal steroids. J. Membr. Biol. 144: 93-110, 1995.
43. + transport in cultured kidney cells. Am. J. Physiol. 242 (Renal Fluid Electrolyte Physiol. 11): F610-F619, 1982.
44. Wilson, R. C., M. D. Harbison, Z. S. Krozowski, J. W. Funder, C. H. Shackleton, H. M. Hanauske-Abel, J. Q. Wei, J. Hertecant, A. Moran, and R. E. Neiberger. Several homozygous mutations in the gene for 11β-hydroxysteroid dehydrogenase type 2 in patients with apparent mineralocorticoid excess. J. Clin. Endocrinol. Metab. 80: 3145-3150, 1995.