Moisture-induced aggregation of lyophilized DNA and its prevention

Pharmaceutical Research

Volumn 24, Issue 1, 2007, Pages 168-175

  Sharma, Vikas K ^a,b   Klibanov, Alexander M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b GENENTECH INC   (United States)

Author keywords

Aggregation; DNA; Lyophilization; Moisture; Relative humidity; Solid state

Indexed keywords

DEXTRAN; PLASMID DNA; SINGLE STRANDED DNA; SODIUM CHLORIDE; SUCROSE;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CALF (BOVINE); CONTROLLED STUDY; DNA SUPERCOILING; DRUG RESEARCH; DRUG SOLUBILITY; FREEZE DRYING; HUMIDITY; HYDROGEN BOND; INCUBATION TIME; MOISTURE; NONHUMAN; PH; PRIORITY JOURNAL; THYMUS; WATER TRANSPORT;

ANIMALS; CATTLE; CHEMISTRY, PHYSICAL; DEXTRANS; DNA; DNA, SUPERHELICAL; FREEZE DRYING; HUMIDITY; HYDROGEN-ION CONCENTRATION; PLASMIDS; SODIUM CHLORIDE; SOLUBILITY; SUCROSE; TEMPERATURE; THYMUS GLAND; WATER;

EID: 33845429466     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9138-7     Document Type: Article

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