The PTHrP-Ihh feedback loop in the embryonic growth plate allows PTHrP to control hypertrophy and Ihh to regulate proliferation

Biomechanics and Modeling in Mechanobiology

Volumn 6, Issue 1-2, 2007, Pages 55-62

  Van Donkelaar, C C ^a   Huiskes, R ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ENGINEERING; BONE; CELLS; FEEDBACK CONTROL;

CONTROL HYPERTROPHY; FEEDBACK LOOP; MECHANICAL LOADING; REGULATE PROLIFERATION;

GROWTH KINETICS;

PARATHYROID HORMONE RELATED PROTEIN; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL PROLIFERATION; CYTOLOGY; FEEDBACK SYSTEM; GROWTH PLATE; HYPERTROPHY; METABOLISM; MOUSE; PATHOLOGY; PRENATAL DEVELOPMENT; PROTEIN TRANSPORT;

ANIMALS; CELL PROLIFERATION; FEEDBACK, BIOCHEMICAL; GROWTH PLATE; HYPERTROPHY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN TRANSPORT;

EID: 33845412477     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-006-0035-0     Document Type: Article

References (47)

1. Amizuka N, Davidson D, Liu H, Valverde-Franco G, Chai S, Maeda T, Ozawa H, Hammond V, Ornitz DM, Goltzman et al. (2004) Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Bone 34:13-25
2. Bailon-Plaza A, van der Meulen MC (2001) A mathematical framework to study the effects of growth factor influences on fracture healing. J Theor Biol 212:191-209
3. Casali A, Struhl G (2004) Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 431:76-80
4. Chung UI, Lanske B, Lee K, Li E, Kronenberg H (1998) The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci USA 95:13030-13035
5. D'Angelo M, Sarment DP, Billings PC, Pacifici M (2001) Activation of transforming growth factor in chondrocytes undergoing endochondral ossification. J Bone Miner Res 16:2339-2347
6. Edelman ER, Nugent MA, Karnovsky MJ (1993) Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci USA 90:1513-1517
7. van't Veen SJ, Hagen JW, van Ginkel FC, Prahl-Andersen B, Burger EH (1995) Intermittent compression stimulates cartilage mineralization. Bone 17:461-465
8. van der Eerden BC, Karperien M. Gevers EF, Lowik CW, Wit JM (2000) Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res 15:1045-1055
9. Garcia AM, Frank EH, Grimshaw PE, Grodzinsky AJ (1996) Contributions of fluid convection and electrical migration to transport in cartilage: relevance to loading. Arch Biochem Biophys 333:317-325
10. Karp SJ, Schipani E, St JacquesB, Hunzelman J, Kronenberg H, McMahon AP (2000) Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 127:543-548
11. Karperien M, Lanser P, De Laat SW, Boonstra J, Defize LHK (1996) Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes. Int J Dev Biol 40:599-608
12. Klein-Nulend J, Veldhuijzen JP, Burger EH (1986) Increased calcification of growth plate cartilage as a result of compressive force in vitro. Arthritis Rheum 29:1002-1009
13. Klein-Nulend J, Veldhuijzen JP, van de Stadt RJ, van Kampen GP, Kuijer R, Burger EH (1987) Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro. J Biol Chem 262:15490-15495
14. Kobayashi T, Chung UI, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM (2002) PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development 129:2977-2986
15. Koziel L, Kunath M, Kelly OG, Vortkamp A (2004) Extl-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev Cell 6:801-813
16. Kronenberg HM (2003) Developmental regulation of the growth plate. Nature 423:332-336
17. Leddy HA, Guilak F (2003) Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann Biomed Eng 31:753-760
18. Lee K, Lanske B, Karaplis AC, Deeds JD. Kohno H, Nissenson RA, Kronenberg HM, Segre GV (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137:5109-5118
19. Lerner AL, Kuhn JL, Hollister SJ (1998) Are regional variations in bone growth related to mechanical stress and strain parameters? J Biomech 31:327-335
20. Long F, Linsenmayer TF (1998) Regulation of growth region cartilage proliferation and differentiation by perichondrium. Development 125:1067-1073
21. Minina E, Kreschel C, Naski MC. Ornitz DM, Vortkamp A (2002) Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell 3:439-449
22. Mosley JR, Lanyon LE (2002) Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical strain. Bone 30:314-319
23. Nakamata T, Aoyama T, Okamoto T, Hosaka T, Nishijo K, Nakayama T, Nakamura T. Toguchida J (2003) In vitro demonstration of cell-to-cell interaction in growth plate cartilage using chondrocytes established from p53-/- mice. J Bone Miner Res 18:97-107
24. Naski MC, Ornitz DM (1998) FGF signaling in skeletal development. Front Biosci 3:d781-d794
25. Nimer E, Schneiderman R, Maroudas A (2003) Diffusion and partition of solutes in cartilage under static load. Biophys Chem 106:125-146
26. Ohashi N, Robling AG, Burr DB, Turner CH (2002) The effects of dynamic axial loading on the rat growth plate. J Bone Miner Res 17:284-292
27. Ornitz DM, Marie PJ (2002) FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 16:1446-1465
28. Pathi S, Pagan-Westphal S, Baker DP, Garber EA, Rayhorn P, Bumcrot D, Tabin CJ, Blake Pepinsky R, Williams KP (2001) Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 106:107-117
29. Quinn TM, Kocian P, Meister JJ (2000) Static compression is associated with decreased diffusivity of dextrans in cartilage explants. Arch Biochem Biophys 384:327-334
30. Quinn TM, Morel V, Meister JJ (2001) Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. J Biomech 34: 1463-1469
31. Quinn TM, Studer C, Grodzinsky AJ, Meister JJ (2002) Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants. J Biochem Biophys Methods 52:83-95
32. Robling AG, Duijvelaar KM, Geevers JV, Ohashi N, Turner CH (2001) Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force. Bone 29:105-113
33. Sengers BG. Heywood HK, Lee DA. Oomens CWJ, Bader DL (2005) Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng 121:758-766
34. Shao YY, Wang L, Ballock RT (2005) The molecular basis of the Heuter-Volkman Principle of physeal growth. In: Proceedings of the 51st Annual Meeting of the Orthopaedic Research Society, Washington DC.,#1054
35. Shimo T, Gentili, C, Iwamoto M, Wu C, Koyama E, Pacifici M (2004) Indian hedgehog land syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis. Dev Dyn 229:607-617
36. Sniekers YH, van Donkelaar CC (2005) Determining diffusion coefficients in inhomogeneous tissues using fluorescence recovery after photobleaching. Biophys J 89:1302-1309
37. St Jacques B, Hammerschmidt M, McMahon AP (1999) Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086
38. Stevens DA, Williams GR (1999) Hormone regulation of chondrocyte differentiation and endochondral bone formation. Mol Cell Endocrinol 151:195-204
39. Stokes IA, Aronsson DD, Cortright V. Beck S (2005) Endochondral growth in growth plates of three species at two anatomical locations modulated by mechanical compression and distraction.In: Proceedings of the 51st Annual Meeting of the Orthopaedic Research Society, Washington DC.,# 1047
40. Tanaka N, Ohno S, Honda K, Tanimoto K, Doi T, Ohno-Nakahara M, Tafolla E, Kapila S, Tanne K (2005) Cyclic mechanical strain regulates the PTHrP expression in cultured chondrocytes via activation of the Ca2+ channel. J Dent Res 84:64-68
41. Tanck E, Blankevoort L, Haaijman A, Burger EH, Huiskes R (2000) Influence of muscular activity on local mineralization patterns in metatarsals of the embryonic mouse. J Orthop Res 18:613-619
42. Tanck E, Van Donkelaar CC, Jepsen KJ, Goldstein SA, Weinans H, Burger EH, Huiskes R (2004) The mechanical consequences of mineralization in embryonic bone. Bone 35:186-190
43. Torzilli PA, Arduino JM, Gregory JD, Bansal M (1997) Effect of proteoglycan removal on solute mobility in articular cartilage. J Biomech 30:895-902
44. Volk SW, Leboy PS (1999) Regulating the regulators of chondrocyte hypertrophy. J Bone Miner Res 14:483-486
45. Vortkamp A, Lee K, Lanske B, Segre GV. Kronenberg HM. Tabin CJ (1996) Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273:613-622
46. Wu Q, Zhang Y, Chen Q (2001) Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation. J Biol Chem 276:35290-35296
47. Zhao Q, Brauer PR, Xiao L, McGuire MH, Yee JA (2002) Expression of parathyroid hormone-related peptide (PthrP) and its receptor (PTH1R) during the histogenesis of cartilage and bone in the chicken mandibular process. J Anat 201:137-151