Pivotal advance: CD69 targeting differentially affects the course of collagen-induced arthritis

Journal of Leukocyte Biology

Volumn 80, Issue 6, 2006, Pages 1233-1241

  Sancho, David ^a,d   Gómez, Manuel ^a   Del Hoyo, Gloria Martinez ^a   Lamana, Amalia ^a   Esplugues, Enric ^b   Lauzurica, Pilar ^b   Martinez A, Carlos ^c   Sánchez Madrid, Francisco ^a,e  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

Antibodies; Autoimmunity; Chemokines; Cytokines; T cells

Indexed keywords

CD69 ANTIBODY; CD69 ANTIGEN; COLLAGEN; COLLAGEN TYPE 2; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G; LEUKOCYTE ANTIGEN; T LYMPHOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTHRITIS; ARTICLE; CELL PROLIFERATION; CELL SURFACE; CELL TRANSFER; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; INFLAMMATION; LEUKOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; DBA MOUSE; GENETICS; IMMUNOLOGY; LYMPHOCYTE DEPLETION; METHODOLOGY; MOUSE MUTANT;

ANIMALIA;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ARTHRITIS, EXPERIMENTAL; CELL PROLIFERATION; COLLAGEN TYPE II; IMMUNOGLOBULIN G; INFLAMMATION; INTERFERON TYPE II; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 33845411549     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1205749     Document Type: Article

References (32)

1. Myers, L. K., Rosloniec, E. F., Cremer, M. A., Kang, A. H. (1997) Collagen-induced arthritis, an animal model of autoimmunity. Life Sci. 61, 1861-1878.
2. O'Shea, J. J., Ma, A., Lipsky, P. (2002) Cytokines and autoimmunity. Nat. Rev. Immunol. 2, 37-45.
3. Kadowaki, K. M., Matsuno, H., Tsuji, H., Tunru, I. (1994) CD4+ T cells from collagen-induced arthritic mice are essential to transfer arthritis into severe combined immunodeficient mice. Clin. Exp. Immunol. 97, 212-218.
4. Simon, A. K., Seipelt, E., Sieper, J. (1994) Divergent T-cell cytokine patterns in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 91, 8562-8566.
5. Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359, 693-699.
6. Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., Karlsson, S. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA 90, 770-774.
7. Geiser, A. G., Letterio, J. J., Kulkarni, A. B., Karlsson, S., Roberts, A. B., Sporn, M. B. (1993) Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. Proc. Natl. Acad. Sci. USA 90, 9944-9948.
8. Kuruvilla, A. P., Shah, R., Hochwald, G. M., Liggitt, H. D., Palladino, M. A., Thorbecke, G. J. (1991) Protective effect of transforming growth factor β1 on experimental autoimmune disease in mice. Proc. Natl. Acad. Sci. USA 88, 2918-2921.
9. Hara, T., Jung, L. K., Bjorndahl, J. M., Fu, S. M. (1986) Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o- tetradecanoyl phorbol-13-acetate, mitogens, and antigens. J. Exp. Med. 164, 1988-2005.
10. Cosulich, M. E., Rubartelli, A., Risso, A., Cozzolino, F., Bargellesi, A. (1987) Functional characterization of an antigen involved in an early step of T-cell activation. Proc. Natl. Acad. Sci. USA 84, 4205-4209.
11. Cebrián, M., Yague, E., Rincon, M., Lopez-Botet, M., de Landazuri, M. O., Sanchez-Madrid, F. (1988) Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J. Exp. Med. 168, 1621-1637.
12. Sancho, D., Yanez-Mo, M., Tejedor, R., Sanchez-Madrid, F. (1999) Activation of peripheral blood T cells by interaction and migration through endothelium: role of lymphocyte function antigen-1/intercellular adhesion molecule-1 and interleukin-15. Blood 93, 886-896.
13. Sánchez-Mateos, P., Cebrian, M., Acevedo, A., López-Botet, M., Ortiz de Landazuri, M., Sánchez-Madrid, F. (1989) Expression of a gp33/27,000 MW activation inducer molecule (AIM) on human lymphoid tissues. Induction of cell proliferation on thymocytes and B lymphocytes by anti-AIM antibodies. Immunology 68, 72-79.
14. Laffón, A., Garcia-Vicuña, R., Humbria, A., Postigo, A. A., Corbi, A. L., de Landazuri, M. O., Sánchez-Madrid, F. (1991) Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J. Clin. Invest. 88, 546-552.
15. García-Monzón, C., Moreno-Otero, R., Pajares, J. M., García-Sánchez, A., López-Botet, M., de Landazuri, M. O., Sanchez-Madrid, F. (1990) Expression of a novel activation antigen on intrahepatic CD8+ T lymphocytes in viral chronic active hepatitis. Gastroenterology 98, 1029-1035.
16. Testi, R., Phillips, J. H., Lanier, L. L. (1989) T cell activation via Leu-23 (CD69). J. Immunol. 143, 1123-1128.
17. Sancho, D., Gómez, M., Viedma, F., Esplugues, E., Gordón-Alonso, M., García-López, M., de la Fuente, H., Martínez-A., C., Lauzurica, P., Sánchez-Madrid, F. (2003) CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. J. Clin. Invest. 112, 872-882.
18. Esplugues, E., Sancho, D., Vega-Ramos, J., Martinez, C., Syrbe, U., Hamann, A., Engel, P., Sanchez-Madrid, F., Lauzurica, P. (2003) Enhanced antitumor immunity in mice deficient in CD69. J. Exp. Med. 197, 1093-1106.
19. Nakayama, T., Kasprowicz, D. J., Yamashita, Y., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H., Ziegler, S. F. (2002) The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168, 87-94.
20. Feng, C., Woodside, K. J., Vance, B., El-Khoury, D., Canelles, M., Lee, J., Gress, R., Fowlkes, B. J., Shores, E. W., Love, P. E. (2002) A potential role for CD69 in thymocyte emigration. Int. Immunol. 14, 535-544.
21. Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., et al. (2003) CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int. Immunol. 15, 987-992.
22. Lauzurica, P., Sancho, D., Torres, M., Albella, B., Marazuela, M., Merino, T., Bueren, J. A., Martinez, A. C., Sanchez-Madrid, F. (2000) Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood 95, 2312-2320.
23. Esplugues, E., Vega-Ramos, J., Cartoixa, D., Vazquez, B. N., Salaet, I., Engel, P., Lauzurica, P. (2005) Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood 105, 4399-4406.
24. Leu, R. W., Robinson, C. J., Wiggins, J. A., Shannon, B. J., Rummage, J. A., Horn, M. J. (1988) Photometric assays for FcRI-dependent binding, phagocytosis, and antibody-dependent cellular cytotoxicity mediated by monomeric IgG gamma 2a in murine peritoneal macrophages. J. Immunol. Methods 113, 269-278.
25. Diamond, B., Scharff, M. (1980) IgG1 and IgG2b share the Fc receptor on mouse macrophages. J. Immunol. 125, 631-633.
26. Laouar, Y., Sutterwala, F. S., Gorelik, L., Flavell, R. A. (2005) Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat. Immunol. 6, 600-607.
27. Ishikawa, S., Akakura, S., Abe, M., Terashima, K., Chijiiwa, K., Nishimura, H., Hirose, S., Shirai, T. (1998) A subset of CD4+ T cells expressing early activation antigen CD69 in murine lupus: possible abnormal regulatory role for cytokine imbalance. J. Immunol. 161, 1267-1273.
28. 2+ during activation of lymphocytes from patients with systemic lupus erythematosus. Lupus 6, 48-56.
29. Hernández-García, C., Fernández-Gutiérrez, B., Morado, I. C., Bañares, A. A., Jover, J. A. (1996) The CD69 activation pathway in rheumatoid arthritis synovial fluid T cells. Arthritis Rheum. 39, 1277-1286.
30. McGuirk, P., Mills, L. (2002) Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23, 450-455.
31. Sancho, D., Gomez, M., Sanchez-Madrid, F. (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol. 26, 136-140.
32. McInnes, I. B., Leung, B. P., Sturrock, R. D., Field, M., Liew, F. Y. (1997) Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. Nat. Med. 3, 189-195.