-
1
-
-
0002958235
-
A study on docking mode of hiv protease and their inhibitors
-
Akaho, E., Fujikawa, C., Runion, H. I., Hill, C. R., and Nakaho, H., A study on docking mode of hiv protease and their inhibitors. J. Chem. Software, 5, 147 -162 (1999).
-
(1999)
J. Chem. Software
, vol.5
, pp. 147-162
-
-
Akaho, E.1
Fujikawa, C.2
Runion, H.I.3
Hill, C.R.4
Nakaho, H.5
-
2
-
-
0037820400
-
Potential Inhibitors of angiogenesis. Part I: 3-(imidazolyl-4 (5)-ylmethylene) indolin-2-ones
-
Braud, E. M., Nourrisson, M. R., Tonnerre, A., Picot, C., LeBaut, G., Renard, P., Pfeiffer, B., and Tucker, G., Potential Inhibitors of angiogenesis. Part I: 3-(imidazolyl-4 (5)-ylmethylene) indolin-2-ones. J. Enzyme Inhib. Med. Chem., 18, 243-252 (2003).
-
(2003)
J. Enzyme Inhib. Med. Chem.
, vol.18
, pp. 243-252
-
-
Braud, E.M.1
Nourrisson, M.R.2
Tonnerre, A.3
Picot, C.4
LeBaut, G.5
Renard, P.6
Pfeiffer, B.7
Tucker, G.8
-
3
-
-
37049097276
-
(Z)-and (E)-Arylindene-1,3-dihydro indol-2-ones: Configuration, conformation, and infrared carbonyl stretching frequencies
-
Coda, A. C., Invernizzi, A. G., Righetti, P. P., and Tacconi, G., (Z)-and (E)-Arylindene-1,3-dihydro indol-2-ones: configuration, conformation, and infrared carbonyl stretching frequencies. J. Chem. Soc. Perkin Trans, 2, 615-619 (1984).
-
(1984)
J. Chem. Soc. Perkin Trans
, vol.2
, pp. 615-619
-
-
Coda, A.C.1
Invernizzi, A.G.2
Righetti, P.P.3
Tacconi, G.4
-
4
-
-
0036121457
-
Antiangiogenic agents
-
Cortes-Funes, H., Antiangiogenic agents. Drugs of Today, 38, 11-19 (2002).
-
(2002)
Drugs of Today
, vol.38
, pp. 11-19
-
-
Cortes-Funes, H.1
-
5
-
-
6244283606
-
Critical evaluation of search algorithms for automated molecular docking and database screening
-
Ewing T. J. A. and Kuntz, I. D., Critical evaluation of search algorithms for automated molecular docking and database screening. J. Comput. Chem., 18, 1175-1189 (1997).
-
(1997)
J. Comput. Chem.
, vol.18
, pp. 1175-1189
-
-
Ewing, T.J.A.1
Kuntz, I.D.2
-
6
-
-
0035025191
-
Dock 4.0: Search strategies for automated molecular docking flexible molecule databases
-
Ewing T. J. A., Makino, S., Skillman, A. G., and Kuntz, I. D., Dock 4.0: Search strategies for automated molecular docking flexible molecule databases. J. Comp.-Aid. Mol. Des., 15, 411-428 (2001).
-
(2001)
J. Comp.-Aid. Mol. Des.
, vol.15
, pp. 411-428
-
-
Ewing, T.J.A.1
Makino, S.2
Skillman, A.G.3
Kuntz, I.D.4
-
7
-
-
0036667385
-
Protein tyrosine kinase inhibitors: New treatment modalities
-
Fabbro, D., Parkinson, D., and Matter, A., Protein tyrosine kinase inhibitors: new treatment modalities. Curr. Opin. Pharmacol. 2, 374-381 (2002).
-
(2002)
Curr. Opin. Pharmacol.
, vol.2
, pp. 374-381
-
-
Fabbro, D.1
Parkinson, D.2
Matter, A.3
-
8
-
-
0015311426
-
Anti-angiogenesis: New concepts for theraphy of solid tumors
-
Folkman, J., Anti-angiogenesis: new concepts for theraphy of solid tumors. Ann. Surg., 175, 409-416 (1972).
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
9
-
-
0021978223
-
Tumor angiogenesis
-
Folkman, J., Tumor angiogenesis. Adv. Cancer Res., 43, 175-203 (1985).
-
(1985)
Adv. Cancer Res.
, vol.43
, pp. 175-203
-
-
Folkman, J.1
-
10
-
-
0001360236
-
SU 5416: A potent and selective Flk-1/KDR kinase inhibitor that blocks Flk-1 phosphorylation, endotelhial cell mitogenesis, and tumor growth
-
Fong, T. A. T., Shawver, L. K., App, H., Sun, L., Tang, C., Rice, A., Kim, Y. H., Schreck, R., Chen, J., Dowd, B., Suto, E., Vasile, S., Wang, X., Hirth, K. P., and McMahon, G., SU 5416: a potent and selective Flk-1/KDR kinase inhibitor that blocks Flk-1 phosphorylation, endotelhial cell mitogenesis, and tumor growth. Proc. Am. Assoc. Cancer Res., 39, 560-567 (1998).
-
(1998)
Proc. Am. Assoc. Cancer Res.
, vol.39
, pp. 560-567
-
-
Fong, T.A.T.1
Shawver, L.K.2
App, H.3
Sun, L.4
Tang, C.5
Rice, A.6
Kim, Y.H.7
Schreck, R.8
Chen, J.9
Dowd, B.10
Suto, E.11
Vasile, S.12
Wang, X.13
Hirth, K.P.14
McMahon, G.15
-
11
-
-
0032893263
-
SU 5416: Is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth for multiple tumor types
-
Fong, T. A. T., Shawer, L. K., Sun, L., Tang, C., App, H., Powell, T. J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K. P., and McMahon, G., SU 5416: is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth for multiple tumor types. J. Cancer Res., 59, 99-106 (1999).
-
(1999)
J. Cancer Res.
, vol.59
, pp. 99-106
-
-
Fong, T.A.T.1
Shawer, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
Kim, Y.H.7
Schreck, R.8
Wang, X.9
Risau, W.10
Ullrich, A.11
Hirth, K.P.12
McMahon, G.13
-
12
-
-
0033025957
-
Small molecule inhibitors of tumor promoted angiogenesis, including protein kinase inhibitors
-
Hamby, J. M. and Showalter, H. D. H., Small molecule inhibitors of tumor promoted angiogenesis, including protein kinase inhibitors. Pharmacol. Ther., 82, 169-193 (1999).
-
(1999)
Pharmacol. Ther.
, vol.82
, pp. 169-193
-
-
Hamby, J.M.1
Showalter, H.D.H.2
-
13
-
-
0030029143
-
Discovery of a novel, potent and src family selective tyrosine kinase inhibitor
-
Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A., Discovery of a novel, potent and src family selective tyrosine kinase inhibitor. J. Biol. Chem., 271, 695-701 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 695-701
-
-
Hanke, J.H.1
Gardner, J.P.2
Dow, R.L.3
Changelian, P.S.4
Brissette, W.H.5
Weringer, E.J.6
Pollok, B.A.7
Connelly, P.A.8
-
14
-
-
0030783173
-
Inhibitors of tyrosine kinase
-
Khols, D. W. D., Fry, D. W., and Kraker, A. J., Inhibitors of tyrosine kinase. Curr. Opin. Oncol., 9, 562-568 (1997).
-
(1997)
Curr. Opin. Oncol.
, vol.9
, pp. 562-568
-
-
Khols, D.W.D.1
Fry, D.W.2
Kraker, A.J.3
-
15
-
-
13444267980
-
-
(University of California, San Francisco Web Site)
-
Kuntz, I. D., Dock. 4.0 (University of California, San Francisco Web Site) (1998).
-
(1998)
Dock. 4.0
-
-
Kuntz, I.D.1
-
16
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki, A. and Grazit, A., Tyrosine kinase inhibition: an approach to drug development. Science, 267, 1782-1788 (1995).
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Grazit, A.2
-
17
-
-
0037107887
-
Structure-based virtual screening: An overview
-
Lyne, P. D., Structure-based virtual screening: an overview. Drug Discovery Today, 7, 1047-1055 (2002).
-
(2002)
Drug Discovery Today
, vol.7
, pp. 1047-1055
-
-
Lyne, P.D.1
-
18
-
-
84986432941
-
Automated docking with grid-base evaluation
-
Meng, E. C., Scoichet, B. K., and Kuntz, I. D., Automated docking with grid-base evaluation. J. Comput. Chem., 13, 505-524 (1992).
-
(1992)
J. Comput. Chem.
, vol.13
, pp. 505-524
-
-
Meng, E.C.1
Scoichet, B.K.2
Kuntz, I.D.3
-
19
-
-
0030945871
-
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
-
Mohammadi, M., McMahon, G., Sun, L., Tang, C., Hirth, P., Yeh, B. K., Hubbard, S. R., and Schlessinger, J., Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science, 276, 955-960 (1997).
-
(1997)
Science
, vol.276
, pp. 955-960
-
-
Mohammadi, M.1
McMahon, G.2
Sun, L.3
Tang, C.4
Hirth, P.5
Yeh, B.K.6
Hubbard, S.R.7
Schlessinger, J.8
-
20
-
-
0034104525
-
Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily
-
Noonberg, S. B. and Benz, C. C., Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily. Drugs, 59, 753-767 (2000).
-
(2000)
Drugs
, vol.59
, pp. 753-767
-
-
Noonberg, S.B.1
Benz, C.C.2
-
21
-
-
21744448193
-
c-Src receptor tyrosine kinase with the application of receptor docking studies
-
c-Src receptor tyrosine kinase with the application of receptor docking studies. Farmaco, 60, 497-506 (2005).
-
(2005)
Farmaco
, vol.60
, pp. 497-506
-
-
Olgen, S.1
Akaho, E.2
Nebioglu, D.3
-
22
-
-
0344739766
-
c-Src receptor tyrosine kinase and investigation of the inhibition using receptor docking studies
-
c-Src receptor tyrosine kinase and investigation of the inhibition using receptor docking studies. J. Enzy. Inhib. Med. Chem. 18, 485-490 (2003).
-
(2003)
J. Enzy. Inhib. Med. Chem.
, vol.18
, pp. 485-490
-
-
Olgen, S.1
Akaho, E.2
Nebioglu, D.3
-
23
-
-
0027981473
-
Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2, 2′-dithiobis (1-methyl-N-phenyl-1H-indole-3-carboxamide)
-
Rewcastle, G. W., Palmer, B. D., Dobrusin, E. M., Fry, D. W., Kraker, A. J., and Denny, W. A., Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2, 2′-dithiobis (1-methyl-N-phenyl-1H-indole-3-carboxamide) . J. Med. Chem., 37, 2033-2042 (1994).
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2033-2042
-
-
Rewcastle, G.W.1
Palmer, B.D.2
Dobrusin, E.M.3
Fry, D.W.4
Kraker, A.J.5
Denny, W.A.6
-
24
-
-
0036862019
-
Inhibition of receptor tyrosine kinase-based signal transduction as specific target for cancer treatment
-
Roussidis, A. E. and Karamanos, N. K., Inhibition of receptor tyrosine kinase-based signal transduction as specific target for cancer treatment. In vivo, 16, 459-470 (2002).
-
(2002)
In Vivo
, vol.16
, pp. 459-470
-
-
Roussidis, A.E.1
Karamanos, N.K.2
-
25
-
-
0038185582
-
Binding site characteristics in structure-based virtual screening: Evaluation of current docking tools
-
Schulz-Gasch, T. and Stahl, M., Binding site characteristics in structure-based virtual screening: evaluation of current docking tools. J. Mol. Model., 9, 47-57 (2003).
-
(2003)
J. Mol. Model.
, vol.9
, pp. 47-57
-
-
Schulz-Gasch, T.1
Stahl, M.2
-
26
-
-
0032474915
-
Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular tyrosine kinases
-
Sun, L., Tran, N., Tang, F., App, H., Hirth, P., McMahon, G., and Tang, C., Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular tyrosine kinases. J. Med. Chem., 41, 2588-2603 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2588-2603
-
-
Sun, L.1
Tran, N.2
Tang, F.3
App, H.4
Hirth, P.5
McMahon, G.6
Tang, C.7
-
27
-
-
0032196541
-
CombiDOCK: Structure-based combinatorial docking and library design
-
Sun, Y, Ewing T. J. A., Skillman, A. G., and Kuntz, I. D., CombiDOCK: Structure-based combinatorial docking and library design. J. Comp.-Aid. Mol. Des., 12, 597-604 (1998).
-
(1998)
J. Comp.-Aid. Mol. Des.
, vol.12
, pp. 597-604
-
-
Sun, Y.1
Ewing, T.J.A.2
Skillman, A.G.3
Kuntz, I.D.4
-
28
-
-
19244370071
-
Design, synthesis and evaluations of substituted 3-[(3- Or 4-carboxy ethyl pyrrol-2-yl)methylindenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases
-
Sun, L., Tran, N., Liang, C., Tang, F., Rice, A., Schreck, R., Waltz, K., Shaever, L. K., McMahon, G., and Tang, C., Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxy ethyl pyrrol-2-yl)methylindenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J. Med. Chem., 42, 5120-5130 (1999).
-
(1999)
J. Med. Chem.
, vol.42
, pp. 5120-5130
-
-
Sun, L.1
Tran, N.2
Liang, C.3
Tang, F.4
Rice, A.5
Schreck, R.6
Waltz, K.7
Shaever, L.K.8
McMahon, G.9
Tang, C.10
-
29
-
-
0034644272
-
Identification of substituted 3-[(4, 5, 6, 7-Tetrahydro-1H-indole-2-yl) methylene]-1, 3-hydroindole-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rb tyrosine kinases
-
Sun, L., Tran, N., Liang, C., Hubbard, S., Tang, F., Lipson, K., Schreck, R., Zhou, Y., McMahon, G., and Tang, C., Identification of substituted 3-[(4, 5, 6, 7-Tetrahydro-1H-indole-2-yl) methylene]-1, 3-hydroindole-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rb tyrosine kinases. J. Med. Chem., 43, 2655-2663 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2655-2663
-
-
Sun, L.1
Tran, N.2
Liang, C.3
Hubbard, S.4
Tang, F.5
Lipson, K.6
Schreck, R.7
Zhou, Y.8
McMahon, G.9
Tang, C.10
-
30
-
-
0033597108
-
The myeloid-specific sialic acid binding receptor, CD33, associated with the protein-tyrosine phosphatases, SHP-1 and SHP-2
-
Taylor, V. C., Buckley, C. D., Douglas, M., Cody, A. J., Simmons, D. L., and Freeman, S. D., The myeloid-specific sialic acid binding receptor, CD33, associated with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J. Biol. Chem., 274, 11505-11512 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11505-11512
-
-
Taylor, V.C.1
Buckley, C.D.2
Douglas, M.3
Cody, A.J.4
Simmons, D.L.5
Freeman, S.D.6
-
31
-
-
0036520840
-
A review of protein-small molecule docking methods
-
Taylor, R. D., Jewsbury, P. J., and Essex, J. W., A review of protein-small molecule docking methods. J. Comp.-Aid. Mol. Des., 16, 151-166 (2002).
-
(2002)
J. Comp.-Aid. Mol. Des.
, vol.16
, pp. 151-166
-
-
Taylor, R.D.1
Jewsbury, P.J.2
Essex, J.W.3
-
32
-
-
0026578427
-
Protein-tyrosine kinase inhibitors
-
Terrence, R. B., Protein-tyrosine kinase inhibitors. Drugs of the Future, 17, 119-131 (1992).
-
(1992)
Drugs of the Future
, vol.17
, pp. 119-131
-
-
Terrence, R.B.1
-
33
-
-
0034632750
-
c-Src
-
c-Src. J. Med. Chem., 43, 3134-3147 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3134-3147
-
-
Thompson, A.M.1
Rewcastle, G.W.2
Boushelle, S.L.3
Hartl, B.G.4
Kraker, A.J.5
Lu, G.H.6
Batley, B.L.7
Panek, R.L.8
Showalter, H.D.H.9
Denny, W.A.10
-
34
-
-
0029556753
-
Recent advances in protein tyrosine kinase inhibitors
-
Traxler, P. and Lyndon, N., Recent advances in protein tyrosine kinase inhibitors. Drugs of the Future, 20, 1261-1274 (1995).
-
(1995)
Drugs of the Future
, vol.20
, pp. 1261-1274
-
-
Traxler, P.1
Lyndon, N.2
-
35
-
-
0035953047
-
7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2, 3-d]pyrimidines-potent inhibitors of the tyrosine kinase c-Src
-
Widler, L., Green, J., Missbach, M., Susa, M., and Altmann, E., 7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2, 3-d]pyrimidines-potent inhibitors of the tyrosine kinase c-Src. Bioorg. Med. Chem. Lett., 11, 849-852 (2001).
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 849-852
-
-
Widler, L.1
Green, J.2
Missbach, M.3
Susa, M.4
Altmann, E.5
-
36
-
-
0033152210
-
Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase
-
Zhu, X., Kim, J. L., Newcomb, J. R., Rose, P. E., Stover, D. R., Toledo, L. M., Zhao, H., and Morgenstern, K. A., Structural Analysis of the Lymphocyte-Specific Kinase Lck in Complex with Non-Selective and Src Family Selective Kinase. Structure, 7, 651-661 (1999).
-
(1999)
Structure
, vol.7
, pp. 651-661
-
-
Zhu, X.1
Kim, J.L.2
Newcomb, J.R.3
Rose, P.E.4
Stover, D.R.5
Toledo, L.M.6
Zhao, H.7
Morgenstern, K.A.8
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