Nociceptive stimulus modality-related difference in pharmacokinetic-pharmacodynamic modeling of morphine in the rat

Pharmacology Biochemistry and Behavior

Volumn 85, Issue 2, 2006, Pages 464-473

  Shang, Gang Wei ^a   Liu, Dan Na ^a   Yan, Lai Hong ^b   Cui, Xiu Yu ^b   Zhang, Kui Ping ^c   Qi, Chao ^c   Chen, Jun ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c Nhwa Brain Bio Med Pharma Co   (China)

Author keywords

Anti nociception; Conjugated morphine; High performance liquid chromatography; Mechanical pain response; Pharmacokinetic pharmacodynamic modeling; Thermal pain response; Unconjugated morphine

Indexed keywords

MORPHINE;

ANALGESIA; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; DRUG CONJUGATION; DRUG EFFECT; HYSTERESIS; MALE; MECHANICAL STIMULATION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PREDICTION; PRIORITY JOURNAL; RAT; THERMAL STIMULATION;

ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MODELS, BIOLOGICAL; MORPHINE; PAIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33845313006     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.09.016     Document Type: Article

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