Synthesis of novel 2-(2′-cyclopentyl)- and 2-(2′-cyclohexyl) substituted 1-naphthol derivatives with anticyclooxygenase activity

Current Medicinal Chemistry

Volumn 13, Issue 30, 2006, Pages 3663-3674

  Kongkathip, Ngampong ^a   Hasitapan, Komkrit ^a   Pradidphol, Narathip ^a   Kirtikara, Kanyawim ^b   Jongkon, Nipa ^a   Kongkathip, Boonsong ^a  

^a KASETSART UNIVERSITY   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

2 substituted 1 naphthol; Anti inflammatory activity; COX 1; COX 2; Cyclooxygenase; Naphthol

Indexed keywords

1 (BENZYLOXY) 2 [[1 (METHOXYMETHYL)CYCLOHEXYL]METHYL]NAPHTHALENE; 1 (BENZYLOXY) 2 [[1 (METHOXYMETHYL)CYCLOPENTYL]METHYL]NAPHTHALENE; 1 [(1 METHOXYNAPHTHALEN 2 YL)METHYL]CYCLOHEXYLMETHANOL; 1 [(1 METHOXYNAPHTHALEN 2 YL)METHYL]CYCLOPENTYLMETHANOL; 1 [[1 (BENZYLOXY)NAPHTHALEN 2 YL]METHYL]CYCLOHEXYLMETHANOL; 1 [[1 (BENZYLOXY)NAPHTHALEN 2 YL]METHYL]CYCLOPENTYLMETHANOL; 1 HYDROXY 2 NAPHTHOIC ACID; 1 METHOXY 2 [[1 (HYDROXY)CYCLOHEXYL]METHYL]NAPHTHALENE; 1 METHOXY 2 [[1 (HYDROXY)CYCLOPENTYL]METHYL]NAPHTHALENE; 1 METHOXY 2 [[1 (METHOXYMETHYL)CYCLOHEXYL]METHYL]NAPHTHALENE; 1 METHOXY 2 [[1 (METHOXYMETHYL)CYCLOPENTYL]METHYL]NAPHTHALENE; 1 NAPHTHOL DERIVATIVE; 2 (2' CYCLOHEXYL) 1 NAPHTHOL DERIVATIVE; 2 (2' CYCLOPENTYL) 1 NAPHTHOL DERIVATIVE; 2 [[1 (HYDROXYMETHYL)CYCLOHEXYL]METHYL]NAPHTHALENE 1 OL; 2 [[1 (HYDROXYMETHYL)CYCLOPENTYL]METHYL]NAPHTHALENE 1 OL; 2 [[1 (METHOXYMETHYL)CYCLOPENTYL]METHYL]NAPHTHALENE 1 OL; 3' METHOXYMETHYLNAPHTHYL ETHER DERIVATIVE; 3' METHOXYNAPHTHOL DERIVATIVE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ACETYLSALICYLIC ACID; FLURBIPROFEN; METHYL 1 [(1 METHOXYNAPHTHALEN 2 YL)METHYL]CYCLOHEXANECARBOXYLIC ACID; METHYL 1 [(1 METHOXYNAPHTHALEN 2 YL)METHYL]CYCLOPENTANECARBOXYLIC ACID; METHYL NAPHTHYL ETHER DERIVATIVE; NAPHTHALENE DERIVATIVE; NAPROXEN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC 50; MOUSE; NONHUMAN; REVIEW;

ANIMALS; CELL LINE, TRANSFORMED; CERCOPITHECUS AETHIOPS; CYCLOOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; NAPHTHOLS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VERO CELLS;

EID: 33845309077     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706779026084     Document Type: Review

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