(±)-(1S,2R,5S)-5-amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway

Biochemistry

Volumn 45, Issue 48, 2006, Pages 14513-14522

  Wang, Zhiyong ^a,c   Yuan, Hai ^a   Nikolic, Dejan ^b   Van Breemen, Richard B ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AROMATIZATION; CARBOXYLIC ACIDS; CONFORMATIONS; ENZYMES; NEUROLOGY; SUBSTRATES; TRANSCEIVERS;

INACTIVATOR; NEUROLOGICAL DISEASES; NEUROTRANSMITTER; THERAPEUTIC APPLICATIONS;

ENZYME INHIBITION;

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID DERIVATIVE; 5 AMINO 2 FLUOROCYCLOHEX 3 ENE CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; GABACULINE; N 3 CARBOXYPHENYLPYRIDOXAMINE 5' PHOSPHATE; NEUROTRANSMITTER; 4 AMINOBUTYRIC ACID; 5 AMINO 2 FLUOROCYCLOHEX 3 ENECARBOXYLIC ACID; 5-AMINO-2-FLUOROCYCLOHEX-3-ENECARBOXYLIC ACID; AMINO ACID; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLUORINE;

AROMATIZATION; ARTICLE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ELIMINATION REACTION; ENZYME INACTIVATION; ENZYME SUBSTRATE; EPILEPSY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; SYNTHESIS;

4-AMINOBUTYRATE TRANSAMINASE; AMINO ACIDS, CYCLIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANECARBOXYLIC ACIDS; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORINE; GAMMA-AMINOBUTYRIC ACID; MOLECULAR STRUCTURE;

EID: 33845267173     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061592m     Document Type: Article

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